Centralized sensation, or abnormal pain processing in the brain and spinal cord, may be an important underlying factor complicating the treatment of chronic pain in those with opioid use disorder.
Mindfulness meditation interrupted communication between brain areas involved in processing pain sensations and areas that produce the sense of self. This resulted in reduced pain as individuals lost ownership of the sensation.
Study reveals 27.8% of pain medications with high abuse potential make it all the way through the development process, compared to only 4.7% of medications with lower potential for abuse.
The absence of the NCX3 gene amplifies pain signals within the spinal cord, a new mouse study reveals. Increasing levels of NCX3 in the spinal cord helped reduce symptoms associated with chronic pain.
Neuroimaging study reveals those suffering from Gulf War Syndrome who experience chronic pain have increased volume in brain areas associated with pain processing and smaller volume in areas associated with pain regulation.
On average, women who self-harm have a higher tolerance to pain than those who do not self-injure. Brain scans revealed greater connectivity between brain areas involved in pain perception and pain modulation in those who self-harm.
Researchers report activating a pathway between the amygdala and brain stem helps to relieve pain and reduce defensive behaviors in rat models.