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          Pain

          Pain Neuroscience news articles cover science research about pain receptors, nociceptors, nociception, sensory neurons, somatosensory cortex, chronic pain, acute pain, nocioceptors, musculoskeletal pain, therapies, phantom limb pain and other pain research.

          This shows a spine.
          FeaturedGeneticsNeurologyNeurosciencePain
          ·April 23, 2025·4 min read

          Clearing Zombie Cells Eases Back Pain

          A new preclinical study has found that two drugs—o-Vanillin and RG-7112—can clear “zombie cells” from spinal discs, potentially treating the root cause of chronic low back pain. These senescent cells accumulate with age or injury and cause inflammation, pain, and tissue damage.
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          This shows a neuron.
          FeaturedNeurologyNeurosciencePain
          ·April 13, 2025·10 min read

          Lab-Grown Nerve Circuit Recreates Human Pain Pathway

          Researchers have recreated the human ascending sensory pathway in a lab dish, using organoids that model the key brain and spinal cord regions responsible for transmitting pain. This breakthrough allows scientists to observe how pain signals travel from peripheral neurons to the brain for the first time outside the body.
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          This shows a brain.
          FeaturedNeurologyNeurosciencePain
          ·April 13, 2025·6 min read

          Why You Sometimes Don’t Feel Pain Until It’s Too Late

          New research highlights how the brain’s own chemistry can suppress pain, explaining why severely injured individuals, like WWII soldiers, sometimes feel little discomfort. The key lies in a brain region called the periaqueductal grey (PAG), which dampens pain signals before they reach conscious awareness.
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          This shows two heads and brains.
          FeaturedNeurologyPain
          ·April 10, 2025·5 min read

          Oral Health Tied to Migraines and Fibromyalgia Pain in Women

          Poor oral health is significantly linked to increased migraine, abdominal, and musculoskeletal pain in women, particularly those with fibromyalgia. Researchers identified specific oral microbes associated with higher pain scores, highlighting a potential gut-brain-oral microbiome connection.
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          This shows a woman in pain.
          FeaturedNeurologyNeurosciencePain
          ·April 4, 2025·5 min read

          Female Hormones Trigger Pain Relief via Immune Cells

          Scientists have discovered that female hormones like estrogen and progesterone can trigger immune cells near the spinal cord to release natural opioids, easing pain before it reaches the brain. These immune cells, known as T regulatory cells (T-regs), are located in the meninges and produce the painkilling molecule enkephalin in response to hormonal signals.
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          This shows a rubber hand.
          FeaturedNeurologyNeurosciencePainPsychology
          ·March 19, 2025·5 min read

          Rubber Hand Illusion Reduces Pain Perception

          A new study shows that the rubber hand illusion can reduce the intensity of pain caused by heat. Researchers found that when participants viewed a rubber hand being illuminated while their hidden hand received a heat stimulus, they reported feeling less pain.
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          This shows a brain and trees.
          FeaturedNeurologyNeurosciencePain
          ·March 15, 2025·5 min read

          Nature’s Painkiller: How Virtual Scenes Ease Pain in the Brain

          Viewing natural scenes can significantly reduce how people perceive pain, a new neuroimaging study has found. Researchers discovered that participants reported less pain and exhibited altered brain activity associated with pain perception while looking at virtual nature, compared to urban or office environments.
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          This shows a woman and leaves.
          FeaturedNeurologyNeurosciencePain
          ·March 14, 2025·6 min read

          Cannabis Terpenes Offer New Hope for Chronic Pain, Fibromyalgia

          New research has identified cannabis-derived terpenes—compounds that give plants their distinctive aroma—as effective treatments for fibromyalgia and post-surgical pain. In preclinical mouse models, terpenes such as geraniol and linalool significantly reduced chronic pain, providing promising alternatives to opioid medications and avoiding THC's psychoactive side effects.
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          This shows a brain and neurons representing pain.
          FeaturedNeurologyNeurosciencePain
          ·March 5, 2025·4 min read

          Brain Distinguishes Pain and Itch Using Separate Neural Circuits

          A new study reveals that pain and itch are processed by distinct neural circuits in the anterior cingulate cortex (ACC). Researchers identified two types of neurons—one responding to both stimuli and another selectively activated by either pain or itch.
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          This shows THC and CBD molecules.
          FeaturedNeurosciencePain
          ·February 6, 2025·6 min read

          How CBD Modulates THC’s Impact on the Brain

          Researchers have identified how CBD interacts with cannabinoid receptors to mitigate the negative effects of THC, the psychoactive component of cannabis. Unlike THC, which fully activates the receptor and causes side effects like memory loss and addiction, CBD acts as a modulator, fine-tuning receptor activity.
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          This shows a man in pain.
          FeaturedNeurologyNeurosciencePain
          ·January 13, 2025·3 min read

          Brain Oscillations Decode Pain Intensity

          Parvalbumin (PV) interneurons in the primary somatosensory cortex (S1) have been identified as key players in encoding pain intensity and driving gamma oscillations, according to a study. Cross-species experiments confirmed that gamma oscillations in S1 selectively reflect pain levels in humans and are linked to PV interneuron activity in rodents. Optogenetic manipulation of these interneurons demonstrated their ability to modulate pain-related behaviors, solidifying their role in pain processing.
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          This shows a neuron.
          FeaturedNeurologyNeurosciencePain
          ·December 9, 2024·3 min read

          New Target for Chronic Pain Identified

          Researchers have identified a natural substance, hederagenin, that blocks the NPFFR1 receptor, a protein involved in pain perception in the brain and spinal cord. NPFFR1 has long been a challenging target due to its similarities to related receptors, but advanced screening and computer modeling revealed its unique binding mode.
          Read More
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          This shows an ear.

          Gene Therapy Restores Hearing in Those with Deafness

          This shows a brain.

          Forever Chemicals May Disrupt Brain Development

          This shows kids playing games.

          Kids Outsmart AI in Puzzle Game That Builds Critical Thinking

          This shows a neuron.

          Drug-Coated Neural Implants Reduce Immune Rejection

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