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Genetics

Genetics articles related to neuroscience research will be listed here.

·August 2, 2012·3 min read

Planarians Offer A Better View of Eye Development

Planarian flatworms have come under intense study for their renowned ability to regenerate any missing body part, even as adults. But now they may take on a starring role as a model system for studying eye development and eye diseases in vertebrates, including humans.

Featured Genetics Neurology

·August 2, 2012·3 min read

Researchers Find Genetic Cause for Body Tremors

Scientists knew that mutations in the FUS gene (Fused in Sarcoma) cause amyotrophic lateral sclerosis (ALS), a disease of the nerve cells in the brain and spinal cord that control voluntary muscle movement. The researchers were successful in identifying mutations in this gene that cause Essential Tremor, and proved that the disease mechanisms for ET and ALS FUS mutations are different.

Brain Cancer Featured Genetics Neurology

·August 1, 2012·3 min read

Researchers Discover Gene that Permanently Stops Cancer Cell Proliferation

Researchers discovered a mutant form of Chk1 gene that when expressed in cancer cells, permanently stopped their proliferation and caused cell death without the addition of any chemotherapeutic drugs. This study illustrates an unprecedented finding, that artificially activating Chk1 alone is sufficient to kill cancer cells.

Brain Cancer Featured Genetics Neurology

·August 1, 2012·2 min read

Study Suggests New Treatment Target for Deadly Brain Tumors

“We identified a subset of brain tumor cells that are slower growing or remain at rest, and appear to be the source of cancer recurrence after standard therapy in which the drug temozolomide is given to stop the tumor’s growth,” said Dr. Luis Parada. “Current therapy targets fast-growing tumor cells but not those responsible for new tumors. To the best of our knowledge, this is the first identification of a cancer stem-like cell in a spontaneously forming tumor inside a mammal.”

Featured Genetics Neuroscience

·July 31, 2012·4 min read

Protein Involved in DNA Replication, Centrosome Regulation Linked to Dwarfism, Small Brain Size

Research just published by scientists at Cold Spring Harbor Laboratory (CSHL) links gene mutations found in some patients with Meier-Gorlin syndrome (MGS) with specific cellular dysfunctions that are thought to give rise to a particularly extreme version of dwarfism, small brain size, and other manifestations of abnormal growth which generally characterize that rare condition.

Electrophysiology Featured Genetics Neurology

·July 18, 2012·2 min read

Protein Build-Up Leads to Neurons Misfiring

Using a two-photon microscope capable of peering deep within living tissue, researchers at the University of California, San Diego School of Medicine have found new evidence that alpha-synuclein protein build-up inside neurons causes them to not only become leaky, but also to misfire due to calcium fluxes.

Featured Genetics Neurology Neuroscience Business

·July 17, 2012·3 min read

Experimental Drug May Extend Therapeutic Window for Stroke

An experimental drug that reduces brain damage and improves motor skills among stroke-afflicted rodents when given with federally approved clot-busting therapy has been created.

Featured Genetics Neurology

·July 16, 2012·2 min read

Gene Therapy Treatment Extends Lives of Mice with Fatal Disease, Spinal Muscular Atrophy

Mice born with Spinal Muscular Atrophy typically only live five to six days. University of Missouri researchers introduced the SMN gene into the mice’s central nervous systems and were able to extend their lives 10-25 days longer.

Featured Genetics Neuroscience

·July 16, 2012·3 min read

Neurons Derived from Cord Blood Cells May Represent New Therapeutic Option

The researchers demonstrated that cord blood cells, which come from the mesoderm, the middle layer of embryonic germ cells, can be switched to ectodermal cells, outer layer cells from which brain, spinal and nerve cells arise. "This study shows for the first time the direct conversion of a pure population of human cord blood cells into cells of neuronal lineage by the forced expression of a single transcription factor," says Juan Carlos Izpisua Belmonte.

Featured Genetics Neurology

·July 11, 2012·3 min read

Gene Link to Multiple Sclerosis Explains Drug Side Effects

The biological role of a gene variant implicated in multiple sclerosis (MS) has been determined by researchers at Oxford University. The researchers investigated one particular genetic variant - found in a gene called TNFRSF1A - which has previously been associated with the risk of developing MS.

Featured Genetics Neurology

·July 11, 2012·3 min read

Two Proteins Offer a Clearer Way to Treat Huntington’s Disease

HD mice crossbred with mice that produced greater levels of PGC-1alpha showed dramatic improvement. Production of misfolded proteins was essentially eliminated and the mice behaved normally. “Degeneration of brain cells is prevented. Neurons don’t die,” said La Spada.

Featured Genetics Neurology

·July 9, 2012·4 min read

Researchers Discover Gene Defect for New Syndrome

Research teams discovered a gene defect linked to a cluster of systemic complications, including life-threatening thoracic aortic disease and intracranial aneurysms. The new syndrome is similar, but distinct from known syndromes such as Marfan and Loeys-Dietz syndrome.

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