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TDP-43

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Featured Neurology Neuroscience

·December 19, 2019·4 min read

Is there a link between lifetime lead exposure and dementia?

A new hypothesis suggests declining rates of dementia could be a result of generational differences in lifetime exposure to lead.

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Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·April 30, 2019·5 min read

When is Alzheimer’s not Alzheimer’s? Researchers characterize a different form of dementia

LATE, a form of dementia that appears in the oldest-old is often mistaken for Alzheimer's disease, but the brain pathology is very different. The protein TDP-43 appears to play a significant role in the development of LATE. The neurodegenerative disease may progress more gradually than Alzheimer's, but when combined with Alzheimer's disease (a common combination), appears to cause a more rapid decline than either would alone.

dna

Featured Genetics Neurology

·January 15, 2019·5 min read

Potential Therapeutic Target for ALS Revealed

Researchers have identified the gene STMN2 as a novel biomarker and potential drug target for ALS.

researchers

Featured Genetics Neurology

·March 22, 2018·4 min read

Focusing on Early Stage of Illness May Be Key to Treating ALS

A new study reveals many inhibitory neurons are lost in early phases of ALS and FTD development. The findings show a contrast to other neurodegenerative diseases where excitatory neurons are lost early in the disorders.

cells

Featured Genetics Neurology

·March 19, 2018·5 min read

Better Understanding ALS by Looking at How Cells Change

A new study sheds light on the molecular mechanisms behind ALS.

neurons

Featured Neurology

·February 20, 2018·4 min read

Brain Immune System is Key to Recovery from Motor Neuron Degeneration

Researchers report microglia is critical for neuronal survival in ALS.

brain slices

Featured Genetics Neurology Open Neuroscience Articles

·November 13, 2017·4 min read

Deadly Combination in Neurodegenerative Diseases Revealed

A new mouse model has been developed that captures the pathology of sporadic neurodegenerative diseases.

Image shows a dna strand.

Featured Genetics Neurology

·August 19, 2017·6 min read

Fundamental ALS Pathology Discovered

Researchers have identified a genetic mutation associated with both ALS and frontotemporal dementia.

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Featured Neurology Open Neuroscience Articles

·May 30, 2017·5 min read

Motor Neuron Disease Discovery Offers New Insights into Potential Treatment Targets

A new study sheds light on how some forms of motor neuron disease begins and progresses at a cellular level.

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Featured Genetics Neurology

·April 13, 2017·6 min read

Gene Silencing Shows Promise For Treating ALS and SCA2

New studies find a drug designed to combat the gene that causes SCA2 could also be beneficial in the fight against ALS.

Image shows the structure of TDP-43.

Featured Genetics

·November 7, 2016·3 min read

New Mouse Model of ALS More Closely Mimics Human Disease

Researchers have developed a new mouse model of ALS that could help provide better understanding of the progressive nature of the disease.

Image of an Alzheimer's brain slice.

Featured Neurology

·September 30, 2016·3 min read

Abnormal Brain Protein May Contribute to Development of Alzheimer’s

A new study reports on the role the protein TDP-43 plays in the development of Alzheimer's disease.

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