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          TDP-43

          This shows astrocytes at a synapse
          FeaturedNeurologyNeuroscience
          ·April 20, 2023·5 min read

          Cognitive Decline May Be Triggered by Astrocyte Dysfunction

          A new study reveals astrocyte dysfunction may be a driver of cognitive decline and memory loss in those with dementia. This may be caused by a protein build-up in the astrocytes that appears to trigger abnormal antiviral activity that results in memory loss.
          Read More
          Image shows dna.
          FeaturedGeneticsNeurology
          ·April 13, 2017·6 min read

          Gene Silencing Shows Promise For Treating ALS and SCA2

          New studies find a drug designed to combat the gene that causes SCA2 could also be beneficial in the fight against ALS.
          Read More
          cells
          FeaturedGeneticsNeurology
          ·March 19, 2018·5 min read

          Better Understanding ALS by Looking at How Cells Change

          A new study sheds light on the molecular mechanisms behind ALS.
          Read More
          The image shows a coronal view of a brain scan of a person with ALS.
          FeaturedNeurology
          ·March 1, 2013·3 min read

          Misplaced Molecules: New Insights into the Causes of Dementia

          New research supports the idea that a malfunction of the TDP-43 protein plays a decisive role in the development of ALS and FTD.
          Read More
          This shows tdp43
          FeaturedGeneticsNeurologyNeuroscience
          ·February 11, 2020·4 min read

          Speeding up treatments for ALS

          Study reports protein aggregates within cells are cleared out by the endocytosis process. The findings could help with the development of new treatments for ALS.
          Read More
          This shows DNA
          FeaturedGeneticsNeurologyNeuroscience
          ·March 16, 2023·5 min read

          DNA Treatment Could Delay Paralysis That Strikes Nearly All Patients With ALS

          DNA designer therapeutics restored levels of a protein critical to motor neuron function, restoring the activity that is impaired as a result of ALS.
          Read More
          This shows neurons.
          FeaturedGeneticsNeurologyNeuroscience
          ·May 26, 2026·10 min read

          Gene Therapy Proven to Shield Brain from TDP-43 Damage

          An experimental gene therapy called SynCav1 can protect the central nervous system from the cognitive decline linked to TDP-43-related proteinopathy, a primary driver of FTD, ALS, and over half of all Alzheimer’s cases.
          Read More
          This shows irises.
          FeaturedNeurologyNeuroscience
          ·March 11, 2026·7 min read

          Retinal Scans Differentiate Between Neurodegenerative Diseases

          New polarized light technology allows doctors to distinguish between ALS and Alzheimer's with 96% accuracy using a simple retinal scan.
          Read More
          Image shows a drawing of neurons.
          FeaturedGeneticsNeurologyOpen Neuroscience Articles
          ·January 19, 2016·3 min read

          Intracellular Mechanisms Behind ALS Uncovered

          A new study cancer suppression proteins play key roles in the progression of ALS.
          Read More
          Diagram of mitochondria is shown.
          FeaturedNeuroscience
          ·August 3, 2016·5 min read

          Scientists Keep a Molecule from Moving Inside Nerve Cells to Prevent Cell Death

          Researchers have identified one way in which an RNA binding protein may contribute to ALS.
          Read More
          This shows the outline of a head and a question mark
          FeaturedGeneticsNeurologyNeuroscience
          ·February 28, 2022·4 min read

          A New Molecular Pathway Shared by Two Neurodegenerative Disorders Discovered

          Mislocalization of the TDP-43 protein alters the genetic instructions for UNC13A. The findings provide a potential new therapeutic target for the treatment of ALS and frontotemporal dementia.
          Read More
          dna
          FeaturedGeneticsNeurology
          ·January 15, 2019·5 min read

          Potential Therapeutic Target for ALS Revealed

          Researchers have identified the gene STMN2 as a novel biomarker and potential drug target for ALS.
          Read More
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          A 3D digital rendering showing a developing fetal brain connected by glowing neural pathways and floating DNA strands, surrounded by subtle immune cells.

          How Severe Illness During Pregnancy Alters Fetal Brain Development

          A 3D digital illustration of a human brain side-by-side comparison, highlighting the language centers glowing brightly and equally in both a younger and older brain, while executive function areas are dimmed in the older brain.

          Aging Brains Maintain Robust Language Networks Despite Cognitive Decline

          Rejuvenation of Microglia by Youth Protein TIMP2 in the Aging Brain

          Youth Protein TIMP2 Restores Immune Function in the Aging Brain

          A multi-panel documentary photo. Left: A Black man sits alone on a locker room bench with his head down. Center: A Latino man sits withdrawn at a family kitchen table. Right: A White man looks thoughtfully at wellness pamphlets in a public waiting area. All convey isolation.

          Shame, Stigma, and Culture Prevent Male Domestic Violence Survivors From Seeking Help

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