TDP-43

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TDP-43

Image shows brain slices with deposits of proteins associated with Alzheimer's and Parkinson's disease.

Featured Neurology

·February 5, 2013·3 min read

Study Confirms No Transmission of Alzheimer’s Proteins Between Humans

While evidence suggests pathological proteins linked to the onset and progression of neurodegenerative disorders are capable of spreading from cell-to-cell within the brains of affected individuals, new research shows no evidence to support concerns that these abnormal disease proteins are “infectious” or transmitted from animals to humans or from one person to another.

The image shows a coronal view of a brain scan of a person with ALS.

Featured Neurology

·March 1, 2013·3 min read

Misplaced Molecules: New Insights into the Causes of Dementia

New research supports the idea that a malfunction of the TDP-43 protein plays a decisive role in the development of ALS and FTD.

This is a diagram of the brain and central nervous system.

Featured Neurology

·June 19, 2013·3 min read

Staging System in ALS Shows Potential Tracks of Disease Progression

Performing post-mortem staging of the brains and spinal cord tissue of patients with ALS, researchers discover the neurodegenerative disease could progress from one start point in the CNS to other regions of the brain and spinal cord.

The image shows motor neurons in an ALS patient.

Featured Neurology

·December 16, 2013·5 min read

Researchers Reduce Toxicity Associated With Lou Gehrig’s Disease in Animal Models

Researchers discover a new way of reducing disease toxicity in ALS which slows the dysfunction of neurons.

This image shows neurons.

Featured Neurology Open Neuroscience Articles

·June 3, 2014·3 min read

Molecular ‘Scaffold’ Could Hold Key to New Dementia Treatments

Researchers have discovered how a molecular scaffold, that allows key parts of cells to interact, comes apart in some neurodegenerative diseases.

This image shows a retina cross section from a healthy mouse.

Electrophysiology Featured Genetics

·August 25, 2014·3 min read

Changes in the Eye Can Predict Changes in the Brain

Researchers report retinal degeneration could be one of the earliest signs of FTD in people who have a genetic risk for the disorder.

This image shows neurons from a fruit fly and a person with ALS.

Featured Neurology

·January 23, 2015·3 min read

The Molecular Biology Behind ALS

Researchers report they have identified a molecular defect in motor neurons which could help explain the mechanisms underlying ALS.

Scientists created a mouse model of ALS and FTD caused by mutations in the C9ORF72 gene. Credit: Courtesy of Petrucelli lab, Mayo Clinic, Jacksonville, Fla.

Featured Genetics

·May 22, 2015·4 min read

Scientists Create Mice with a Major Genetic Cause of ALS and FTD

Researchers believe mouse could provide a new platform for testing treatments for several neurodegenerative diseases.

This image shows a model of a head with a cut away exposing the brain.

Featured Genetics Neurology

·June 10, 2015·4 min read

Immune System Linked to Motor Neuron Death in ALS

New findings could help develop treatments to slow the progression of ALS.

This shows a fly leg with the motor neurons showing.

Featured Neuroscience

·August 6, 2015·3 min read

Fly Model of Motor Neuron Degeneration Allows for Study at Single Cell Resolution

Researchers have developed a new model to study neurodegenerative diseases which affect motor neurons, such as ALS.

This image shows the brain of an alzheimer's patient.

Featured Neurology

·August 26, 2015·4 min read

Awareness of Memory Loss Can Decline Up To Three Years Before Alzheimer’s Onset

A new study reports people may lose awareness of their memory loss almost three years prior to Alzheimer's disease setting in.

Image shows stained mouse brain slice. The caption provides more information.

Featured Neurology Neuroscience Videos

·September 30, 2015·3 min read

Dormant Viral Gene May Cause Some Forms of ALS

Researchers discover reactivating ancient viral genes may cause neuron destruction in some forms of ALS.

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