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Tau

This shows brain scans of the hippocampus during sleep

·June 17, 2019·3 min read

Sleep history predicts late-life Alzheimer’s pathology

Your sleep history during middle age may predict Alzheimer's pathology later in life. A decrease in sleep quality between 50 and 70 years of age is associated with higher levels of tau and amyloid beta in the brain. Changes in brain activity and quality of sleep could be a biomarker for Alzheimer's disease.

Featured Neurology Neuroscience

·June 17, 2019·4 min read

Antioxidant puts up fight, but loses battle against protein linked to Alzheimer’s disease

During early Alzheimer's disease, SOD1 initially weakens levels of Tau protein. However, as the disease progresses, the antioxidant becomes less effective at protecting the brain against neurodegeneration.

This shows a virus like protein structure

Featured Neurology Neuroscience Open Neuroscience Articles

·June 11, 2019·4 min read

Memory Preserver: Researchers Develop Vaccine That Could Protect Against Alzheimer’s

Researchers have engineered a vaccine using virus-like particles that target Tau tangles in mouse models of Alzheimer's disease. Following the administration of the vaccine, the mice developed antibodies that cleared tau proteins, with the response lasting for a month. The mice also showed improvements in memory based tests and had less brain shrinkage than their peers who did not receive the vaccine. This suggests the vaccine prevented apoptosis. Researchers hope to move the vaccine to human clinical trials in the future.

This shows someone erasing a drawing of a brain

Featured Neurology Neuroscience Open Neuroscience Articles

·May 14, 2019·4 min read

Brain changes linked with Alzheimer’s up to 30 years before symptoms appear

Researchers have identified average levels of biological and anatomical brain changes associated with Alzheimer's disease over thirty years before symptoms appear. In those with genetic risk factors for Alzheimer's, researchers found changes in cognitive performance up to 15 years before becoming symptomatic. Changes in Tau levels in the cerebral spinal fluid appeared up to 34 years before dementia symptoms occurred, and physical changes to the medial temporal lobe were apparent up to 9 years before cognitive impairment was apparent.

Featured Neurology Neuroscience Visual Neuroscience

·May 7, 2019·6 min read

Why visual stimulation may work in fight against Alzheimer’s: Mouse study

Inducing gamma oscillations with visual stimulation via a process known as gamma entrainment using sensory stimuli, or GENUS, was shown to reduce amyloid plaques and phosphorylated tau in mouse models of dementia. Providing GENUS daily during the early stages of neurodegeneration helps preserve neural and synaptic density across multiple brain areas and improves cognitive performance for learning and spatial memory tasks.

This shows someone carrying out a blood sample analysis

Featured Neurology Neuroscience Open Neuroscience Articles

·May 5, 2019·3 min read

New early detection blood test for Alzheimer’s

A new two-tier diagnostic blood test which evaluates both amyloid beta and tau, can help detect Alzheimer's disease in presymptomatic patients.

Featured Genetics Neurology Neuroscience

·May 1, 2019·9 min read

Alzheimer’s disease is a ‘double-prion disorder’

Self-propagating amyloid and tau act as prions in the pathology of Alzheimer's disease. Higher levels of the prions in human brain samples were strongly correlated with early onset of Alzheimer's and death at a younger age.

Featured Neurology Neuroscience

·April 10, 2019·5 min read

Experimental PET scan detects abnormal tau protein in brains of living former NFL players

PET imaging of former NFL players who exhibited cognitive decline and psychiatric symptoms linked to CTE showed higher levels of tau in areas of the brain associated with the neurodegenerative disease.

Featured Neurology Neuroscience

·February 27, 2019·4 min read

Not All Sleep is Equal When it Comes to Cleaning the Brain

Study reinforces and explains the links between sleep deprivation and neurodegenerative diseases, researchers say.

Featured Neurology Neuroscience Open Neuroscience Articles

·February 26, 2019·9 min read

Hip Fractures May Be An Early Sign of Alzheimer’s in Older People

Researchers report they have identified biomarkers of Alzheimer's disease in spinal fluid samples of a significant number of older patients hospitalized as a result of hip fractures. The study suggests neural alterations that lead to poor balance in older people may signify an increased risk of falls that result in hip fractures, and Alzheimer's disease. Researchers suggest the hip fracture, therefore, may serve as an early sign of Alzheimer's in older patients.

Featured Neurology Neuroscience

·January 25, 2019·5 min read

Sleep Deprivation Accelerates Alzheimer’s Brain Damage

A new study reports sleep deprivation increases the levels of tau, and accelerates the spread of the protein, in the brain. The findings reveal a lack of sleep alone may help drive the development of Alzheimer's disease.

Featured Genetics Neuroscience

·January 17, 2019·3 min read

Epigenetics Contributes to Male and Female Differences in Fear Memories

A new mouse study reveals males recall fearful memories better than females. Researchers attribute the difference to the gene Cdk5, which has previously been implicated in creating fear memories and stress behaviors. The study reports Cdk5 is naturally activated in males, but not females.

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Tau

Sleep history predicts late-life Alzheimer’s pathology

Antioxidant puts up fight, but loses battle against protein linked to Alzheimer’s disease

Memory Preserver: Researchers Develop Vaccine That Could Protect Against Alzheimer’s

Brain changes linked with Alzheimer’s up to 30 years before symptoms appear

Why visual stimulation may work in fight against Alzheimer’s: Mouse study

New early detection blood test for Alzheimer’s

Alzheimer’s disease is a ‘double-prion disorder’

Experimental PET scan detects abnormal tau protein in brains of living former NFL players

Not All Sleep is Equal When it Comes to Cleaning the Brain

Hip Fractures May Be An Early Sign of Alzheimer’s in Older People

Sleep Deprivation Accelerates Alzheimer’s Brain Damage

Epigenetics Contributes to Male and Female Differences in Fear Memories

Chickadees Sneak Around for Brains, Not Just Brawn

Retinal Photos and AI Predict Early Alzheimer’s Risk

AI Voice Scams Weaponize Vocal Timbre to Trick Our Trust

Senescent Cells Are Essential for Building the Brain’s Barriers

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