Neuroscience research articles are provided.
What is neuroscience? Neuroscience is the scientific study of nervous systems. Neuroscience can involve research from many branches of science including those involving neurology, brain science, neurobiology, psychology, computer science, artificial intelligence, statistics, prosthetics, neuroimaging, engineering, medicine, physics, mathematics, pharmacology, electrophysiology, biology, robotics and technology.
– These articles focus mainly on neurology research. – What is neurology? – Definition of neurology: a science involved in the study of the nervous systems, especially of the diseases and disorders affecting them. – Neurology research can include information involving brain research, neurological disorders, medicine, brain cancer, peripheral nervous systems, central nervous systems, nerve damage, brain tumors, seizures, neurosurgery, electrophysiology, BMI, brain injuries, paralysis and spinal cord treatments.
What is Psychology? Definition of Psychology: Psychology is the study of behavior in an individual, or group. Psychology news articles are listed below.
Artificial Intelligence articles involve programming, neural engineering, artificial neural networks, artificial life, a-life, floyds, boids, emergence, machine learning, neuralbots, neuralrobotics, computational neuroscience and more involving A.I. research.
Robotics articles will cover robotics research press releases. Robotics news from universities, labs, researchers, engineers, students, high schools, conventions, competitions and more are posted and welcome.
Genetics articles related to neuroscience research will be listed here.
Neurotechnology research articles deal with robotics, AI, deep learning, machine learning, Brain Computer Interfaces, neuroprosthetics, neural implants and more. Read the latest neurotech news articles below.
Summary: Women with the ApoE e4 genetic risk factor for Alzheimer’s are more susceptible to tau accumulation in the brain than men.
Source: Society of Nuclear Medicine and Molecular Imaging
The strongest genetic risk factor for Alzheimer’s disease is the apolipoprotein E type 4 allele (ApoE ε4). Research presented by Manish Paranjpe at the 2019 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) used positron emission tomography (PET) to show that women who are ApoE ε4 carriers and already experiencing mild cognitive impairment are more susceptible than men to tau accumulation in the brain.
“Sex plays an important role in Alzheimer’s disease risk, with females having a higher lifetime risk of developing the disease and an increased vulnerability to genetic risk factors,” points out Yun Zhou, who led the project at the Mallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine. He explains, “This is the first study to demonstrate that sex modulates the effect of ApoE ε4 on brain tau depositing, measured using 18F-AV-1451-PET imaging, in the entorhinal cortex, amygdala, parahippocampal gyrus, and posterior cingulate of the brains of patients with mild cognitive impairment (MCI). Strikingly, females experience greater ApoE ε4-associated increases in brain tau deposition in these regions compared to their male counterparts.”
This cross-sectional study involved 131 cognitively normal (CN) elderly controls (66 women) and 97 MCI subjects (39 women) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. The mean age of all was 77. Preprocessed 18F-AV-1451 PET images, T1-weighted structural MRI scans and demographic information were included. After downloading pre-processed images from ADNI, a partial volume correction method was applied on all PET images (improving spatial resolution and contrast), and structural MRIs were used for PET spatial normalization. All statistical analyses were performed after controlling for baseline age and education.
In addition to finding women with the ApoE ε4 mutation more susceptible than men to tau accumulation, Zhou notes: “Our study also confirmed that sex does not modulate the ApoE ε4-associated tau deposition in the brains of cognitively normal elderly individuals, and it extends our understanding of how sex modulates the ApoE ε4 effect on tau deposition in the brains of individuals at the early stage of Alzheimer’s disease.”
Paranjpe adds, “Our results have implications for clinical trials, biomarkers, and therapeutic development in Alzheimer’s. In designing clinical trials aimed at an MCI cohort, potentially our study suggests that the dosage of anti-tau antibodies should be modified by ApoE ε4-sex group. Moreover, we hope that insights from our work will shed light on potential treatments for Alzheimer’s disease, including sex-specific tau-targeted and ApoE-targeted drug development.”
[divider]About this neuroscience research article[/divider]
Source: Society of Nuclear Medicine and Molecular Imaging Media Contacts: David Harrison – Society of Nuclear Medicine and Molecular Imaging Image Source: The image is credited to Paranjpe M, Liu M, Paranjpe I, et al.
Original Research: “Sex Modulates the ApoE ε4 Effect on Tau 18F-AV-1451 PET Imaging in Individuals with Normal Aging and Mild Cognitive Impairment,” Manish Paranjpe, University of California, San Francisco; Min Liu, Johns Hopkins Medicine, Baltimore, MD; Ishan Paranjpe, Icahn School of Medicine at Mount Sinai, New York, NY; Rongfu Wang, Peking University First Hospital, Beijing, China; and Tammie Benzinger and Yun Zhou, Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO. The findings will be presented at SNMMI 2019 in Anaheim, California.
[divider]Feel free to share this Neurology News.[/divider]