Exploring the effects of 17 different lifespan-extending interventions on gene activity, researchers identified genetic biomarkers for longevity in mice.
Researchers have created the most comprehensive 'parts list' of the human brain to date. They uncovered crucial differences between human and mouse brain cells. The findings may explain why many drugs used in research do not work in human models.
Prenatal stress can have an epigenetic impact on the future mental health of offspring. Adult children of women who experienced prenatal stress are more vulnerable to stress and other mental health disorders.
Rare variants in the DDX6 gene have been linked to significant disruption in the development of the central nervous system, affecting basic motor skills and resulting in intellectual disabilities.
Study illuminates the role of non-coding mutations in autism spectrum disorder. Researchers say non-coding mutations may also shed light on an array of other neurological and health disorders.
Projection neurons have been implicated in the progression of multiple sclerosis. A new study reports projection neurons are damaged by immune cells. This damage could contribute to both atrophy and cognitive changes associated with the disease.
HIV can persist in the nervous system, even when the virus is suppressed. Even when the virus is suppressed, neurocognitive problems associated with the infection can persist.
Retroviruses may be a missing causal link in diseases like ALS, multiple sclerosis and schizophrenia.
A study of marmoset monkeys reveals a genetic variation of the SLC6A4 repeat region may contribute to anxiety via neurochemical changes in brain areas associated with emotional processing.
A new, comprehensive database of gene activity in mice, which incorporates ten disease models, could significantly reduce the need for animal testing.
Specific transfer RNAs (tRNAs) are associated with epilepsy. The levels of tRNA fragments in blood samples are higher pre-seizure. The findings provide a novel biomarker for the detection of seizures prior to their occurrence.
Findings from a small sample study link small intestinal bacterial overgrowth (SIBO) to restless leg syndrome.
