A new mouse line makes the state of protein balance visible in the mammalian brain for the first time, allowing researchers to investigate disorders associated with protein misfolding.
Researchers have discovered a series of misfolded alpha-synuclein protein structures never previously observed. The alpha-synuclein fibers were larger than previously reported and adopted a striking variety of shapes. The work lays the foundation for a detailed analysis of misfolded alpha-synuclein structures and could provide a better understanding of the neurobiology of Parkinson's disease.
According to researchers, having a little extra fat may help protect against Alzheimer's, Parkinson's and other neurodegenerative diseases.
A new study reports a molecular chaperone can inhibit a key stage in the development of Alzheimer's disease.
A new study could provide additional insights into neurodegenerative diseases which result from misfolded proteins piling up.
Researchers investigate the molecular mechanisms underpinning sleep.
Sleep deprivation could contribute to the dysfunction of pancreatic cells. These functions may be exacerbated by aging, a new study reports.
Researchers find the amino acid, BMAA, can be inserted into neuroproteins. This causes them to misfold and aggregate. BMAA has been detected in the brains of those with ALS.