Lewy body disorders, including Parkinson's disease and Lewy body dementia, comprise of two distinct subtypes. One subtype originates in the peripheral nervous system (PNS) of the gut and spreads to the brain. The other originates in the brain, or enters the brain via the olfactory system, before spreading to the brainstem and PNS.
Schwann cells are much more prolific in generating myelin than previously believed. Knocking out the fbxw7 gene in mouse models, researchers discovered individual Schwann cells began to spread myelin across many axons.
In response to injury, microglia cross the spinal boundary from the central nervous system to the peripheral nervous system. While in the PNS, microglia provide the function of clearing cellular debris at the point of injury, then return to the CNS in an altered state. Researchers propose this could account for some damage associated with neurodegenerative diseases.
A Cell Reports study identifies molecules that allow Schwann cells to help regenerate nerves.
Researchers report motor problems associated with preterm birth could be due to defects in peripheral nerves.
Researchers have identified a mechanism that appears to be responsible for a rare form of pediatric neuropathy.
A new study reveals how Schwann cells in the PNS degrade myelin following nerve injury.
Advances in robotics have made it possible to create artificial legs that can duplicate the natural movement of human legs. The research could help improve the mobility of lower-limb amputees.