Researchers have identified a new reward system in the brain. The study found long-range GABA neurons from the ventral tegmental area to the ventral nucleus accumbens shell are engaged in reward and reinforcement behaviors. This GABAergic projection inhibits cholinergic interneurons.
Opioid use disorder affects genes associated with proinflammatory immune molecule encoding and genes associated with remodeling the extracellular matrix, suggesting the connection between neurons may be altered as a result of opioid use. Additionally, those with OUD have higher levels of microglia in the brain.
Increased activity in the nucleus accumbens forecasted an increase in stock price within the next day, whereas increased activity in the anterior insular was predictive of whether a stock price would flip or change direction.
Glutamatergic neural connections between the prelimbic prefrontal cortex and nucleus accumbens appear to be responsible for co-morbid anxiety and OCD behaviors.
A new study reveals specific brain regions that individually promote patience through the action of serotonin.
Cocaine and sucrose neuron ensembles in the nucleus accumbens are mostly non-overlapping.
Researchers temporarily switched off the neural pathway between the ventral tegmental area and nucleus accumbens in primate models, negatively impacting motivation, but not learning.