As Alzheimer's disease progresses, microglial cells lose two important biological functions affecting their ability to remove cell fragments and motility towards acute lesions.
Researchers discovered a way to stimulate the brain's natural defense mechanisms in mice with Alzheimer's disease symptoms. This major breakthrough opens the door to the development of a treatment for Alzheimer's disease and a vaccine to prevent the illness.
The brain’s key “breeder” cells secrete substances that boost the numbers and strength of critical brain-based immune cells believed to play a vital role in brain health. This finding adds a new dimension to our understanding of how resident stem cells and stem cell transplants may improve brain function.
Research provides the first evidence that mechanisms regulated by the Runx1 gene control the balance between the surveillant versus activated microglia states.
Immune cells “sculpt” circuits in the brain by eating away excess connections Findings offer a fresh look at developmental and...