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Huntington’s disease

Featured Genetics Neurology Neuroscience

·November 13, 2024·7 min read

Huntington’s Gene Enhances Early Brain Growth and Intelligence

A study reveals that the genetic mutation causing Huntington’s disease (HD) enhances brain development and intelligence in early life, but leads to degeneration in adulthood. Children with the HD gene exhibit larger brains and higher IQs than those without the mutation.

Featured Neurology Neuroscience

·November 2, 2024·7 min read

Polymer Therapy Shows Promise Against Huntington’s Disease

Scientists have developed a novel polymer-based therapy that could slow Huntington's disease progression by preventing harmful protein clumps in the brain. In a mouse model, this polymer therapy effectively halted cell death, improved neuron health, and enhanced motor function.

Featured Genetics Neurology Neuroscience

·October 28, 2024·4 min read

Key Biochemical Trigger of Huntington’s Disease Progression Identified

Researchers have identified a crucial biochemical mechanism that could allow Huntington’s disease to be studied before symptoms appear, offering hope for early intervention. The team found that disrupted dopamine regulation in specific neurons, related to TrkB neurotrophin receptor signaling, may trigger Huntington’s onset. By targeting an enzyme called GSTO2, researchers prevented motor symptoms in a mouse model, suggesting this protein's role in the disease's progression.

Featured Genetics Neurology Neuroscience

·September 27, 2024·5 min read

Huntington’s Protein Mutation Blocks DNA Repair

Researchers have discovered that the protein mutated in Huntington’s Disease fails to properly repair DNA, leading to reduced brain cell healing. The huntingtin protein normally stimulates the production of PAR molecules, which gather around damaged DNA to facilitate repair.

Featured Neurology Neuroscience

·June 13, 2023·6 min read

Pathway to Treat Huntington’s & Amyloid Diseases Identified

Researchers identified the structure of the nucleus, the first step in amyloid formation associated with neurodegenerative diseases like Huntington’s. The study suggests a radical method to treat these diseases—halting the initial amyloid formation step.

Featured Neurology Neuroscience

·January 20, 2023·6 min read

How Huntington’s Disease Affects Different Neurons

Researchers have identified how two different populations of neurons in the striatum are affected differently in Huntington's disease. The neurodegeneration of one of these populations leads to motor defects while damage to the other population located in striosomes may account for mood disorders associated with the early stages of Huntington's.

Featured Genetics Neurology Neuroscience

·December 12, 2022·4 min read

CRISPR Technology Improves Huntington’s Disease Symptoms in Models

Using CRISPR gene editing to directly target RNA, researchers eliminated toxic protein buildup associated with Huntington's disease while not disrupting other human genes.

Featured Neurology Neuroscience

·October 28, 2022·6 min read

Cellular Housekeeping Process Implicated in Huntington’s Disease

Study reveals how aging impairs autophagy and how enhancing autophagy can prevent cells from dying in Huntington's disease.

Featured Genetics Neurology Neuroscience

·September 27, 2022·4 min read

Study Probes Huntington’s Disease Protein’s Function in Injured Neurons

The Huntington's disease protein huntingtin may have a role external to the neurodegenerative disease. Researchers say Huntingtin is involved in neural injury and regeneration.