Researchers have identified how two different populations of neurons in the striatum are affected differently in Huntington's disease. The neurodegeneration of one of these populations leads to motor defects while damage to the other population located in striosomes may account for mood disorders associated with the early stages of Huntington's.
Using CRISPR gene editing to directly target RNA, researchers eliminated toxic protein buildup associated with Huntington's disease while not disrupting other human genes.
Study reveals how aging impairs autophagy and how enhancing autophagy can prevent cells from dying in Huntington's disease.
The Huntington's disease protein huntingtin may have a role external to the neurodegenerative disease. Researchers say Huntingtin is involved in neural injury and regeneration.
Researchers discovered decreased function in a protein critical for synaptic function in those with Huntington's disease.
Converting skin cell samples into neurons helps researchers gain a better understanding of the mechanisms of Huntington's disease.
Researchers have created a comprehensive atlas of cell types in the brain's cerebrovascular system.
A new study sheds light on the genetic causes of a range of neurodegenerative disorders, including ALS, Parkinson's disease, and Huntington's disease, and determines factors that impact the age of onset as well as disease severity.
Synthesizing a human embryo from stem cells and using gene editing to insert the Huntingtin gene, researchers found the mutation affected the size of germ layers compared to the control embryos. Findings suggest Huntington's disease may be a neurodevelopmental disorder that presents as a neurodegenerative disease later
Disruption of autophagy may be at the root of the cognitive deficits experienced by those with Huntington's disease.
The mutated huntingtin protein slows ribosome movement and decreases protein synthesis.
A new study adds to the growing body of evidence that the origin of Huntington's disease is rooted in childhood. Researchers say the HTT gene mutation affects both brain and body growth during development, and the increased susceptibility of brain cell death begins early in life.