FeaturedGeneticsNeurology·January 29, 2018·4 min readUncovering the Early Origins of Huntington’s DiseaseRockefeller University researchers reveal Huntington's neurons are much larger than healthy cells.Read More
FeaturedGeneticsNeurology·September 3, 2018·3 min readHuntington’s Disease Starts in ChildhoodResearchers say the Huntingtin gene affects brain development from an early age, even though most patients do not develop Huntington's disease until later life.Read More
Neurology·June 24, 2011·2 min readLithium Profoundly Prevents Brain Damage Associated with Parkinson’s DiseaseBuck Institute research in mice moves into preclinical stage; working toward human trials Lithium profoundly prevents the aggregation of toxic...Read More
FeaturedGeneticsOpen Neuroscience Articles·November 6, 2015·8 min readA New Way to Detect DNA DamageAccording to a new study, researchers have devised a new way to detect chemical damage to DNA that leads to genetic mutations which are responsible for an array of diseases, including ALS and other neurodegenerative diseases.Read More
FeaturedNeurology·July 21, 2013·5 min readFor a Healthy Brain, Don’t Let the Trash Pile UpA new study indicates that quickly clearing away defective proteins in the brain could help prevent some neurodegenerative disorders.Read More
FeaturedGenetics·June 6, 2013·5 min readScientists Coax Brain to Regenerate Cells Lost in Huntington’s DiseaseResearchers mobilize the brain's native stem cells to replenish medium spiny neurons which are lost in Huntington's disease.Read More
FeaturedGeneticsNeurologyNeuroscience·December 12, 2022·4 min readCRISPR Technology Improves Huntington’s Disease Symptoms in ModelsUsing CRISPR gene editing to directly target RNA, researchers eliminated toxic protein buildup associated with Huntington's disease while not disrupting other human genes.Read More
FeaturedGeneticsNeurology·November 22, 2016·3 min readNovel Type of Cell Death in Huntington’s Disease May Lead to Effective New TherapiesResearchers have identified a novel type of cell death associated with Huntington's disease.Read More
FeaturedNeurologyNeuroscience·October 19, 2018·5 min readRegulating Microglial Activity May Reduce Inflammation in Neurodegenerative DiseasesResearchers report activating microglia may help reduce the imbalance between neuroprotection and neurotoxicity for neurodegenerative diseases.Read More
Genetics·September 18, 2012·1 min readNew Findings on Protein MisfoldingResearchers identified 21 proteins that specifically bind to a protein called ataxin-1. Twelve of these proteins enhance the misfolding of ataxin-1 and thus promote the formation of harmful protein aggregate structures, whereas nine of them prevent the misfolding.Read More
FeaturedGeneticsNeurologyOpen Neuroscience Articles·March 6, 2021·4 min readHuntington’s Disease Driven by Slowed Protein-Building Machinery in CellsThe mutated huntingtin protein slows ribosome movement and decreases protein synthesis.Read More
FeaturedGeneticsNeurology·July 11, 2012·3 min readTwo Proteins Offer a Clearer Way to Treat Huntington’s DiseaseHD mice crossbred with mice that produced greater levels of PGC-1alpha showed dramatic improvement. Production of misfolded proteins was essentially eliminated and the mice behaved normally. “Degeneration of brain cells is prevented. Neurons don’t die,” said La Spada.Read More
