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The image shows a single striatal neuron (yellow) transfected with nuclear inclusion (orange) mHtt, other neurons in background (blue).

·January 5, 2015·4 min read

Animal Study Points to a Treatment for Huntington’s Disease

Researchers improve motor function and reduce brain shrinkage in animal models of HD by adjusting the levels of a signaling protein.

The image shows a brain slice from 5 week old mice with htt.

Featured Neurology

·July 9, 2014·4 min read

Huntington’s Disease Protein Helps Wire the Young Brain

The Htt protein, which is mutated in Huntington's disease patients, is critical for wiring the brain in early life, a new study reports.

These slides show the comparison morphographies associated with the research.

Featured Genetics Open Neuroscience Articles

·December 11, 2013·3 min read

Staying Ahead of Huntington’s Disease

Researchers work to understand how expanded polyglutamine tracts form the types of supramolecular structures that are presumed to be toxic to neurons.

Featured Neurology

·September 17, 2012·3 min read

Toxic Protein Build-up in Blood Shines Light on Fatal Brain Disease

A new light-based technique for measuring levels of the toxic protein that causes Huntington's disease (HD) has been used to demonstrate that the protein builds up gradually in blood cells.

Featured Genetics Neurology

·July 11, 2012·3 min read

Two Proteins Offer a Clearer Way to Treat Huntington’s Disease

HD mice crossbred with mice that produced greater levels of PGC-1alpha showed dramatic improvement. Production of misfolded proteins was essentially eliminated and the mice behaved normally. “Degeneration of brain cells is prevented. Neurons don’t die,” said La Spada.