htt

Oldest

htt

·July 11, 2012·3 min read

Two Proteins Offer a Clearer Way to Treat Huntington’s Disease

HD mice crossbred with mice that produced greater levels of PGC-1alpha showed dramatic improvement. Production of misfolded proteins was essentially eliminated and the mice behaved normally. “Degeneration of brain cells is prevented. Neurons don’t die,” said La Spada.

Featured Neurology

·September 17, 2012·3 min read

Toxic Protein Build-up in Blood Shines Light on Fatal Brain Disease

A new light-based technique for measuring levels of the toxic protein that causes Huntington's disease (HD) has been used to demonstrate that the protein builds up gradually in blood cells.

These slides show the comparison morphographies associated with the research.

Featured Genetics Open Neuroscience Articles

·December 11, 2013·3 min read

Staying Ahead of Huntington’s Disease

Researchers work to understand how expanded polyglutamine tracts form the types of supramolecular structures that are presumed to be toxic to neurons.

The image shows a brain slice from 5 week old mice with htt.

Featured Neurology

·July 9, 2014·4 min read

Huntington’s Disease Protein Helps Wire the Young Brain

The Htt protein, which is mutated in Huntington's disease patients, is critical for wiring the brain in early life, a new study reports.

The image shows a single striatal neuron (yellow) transfected with nuclear inclusion (orange) mHtt, other neurons in background (blue).

Featured Genetics Neurology

·January 5, 2015·4 min read

Animal Study Points to a Treatment for Huntington’s Disease

Researchers improve motor function and reduce brain shrinkage in animal models of HD by adjusting the levels of a signaling protein.

Image shows a brain slice from a huntington's patient.

Featured Genetics Neurology Open Neuroscience Articles

·September 9, 2016·5 min read

Activity of Huntington’s Disease Gene Curbed for 6 Months: Mouse Study

Researchers have identified a protein that can turn off the Huntingtin gene's expression.

Image shows fibroblasts from patients with Huntington's disease.

Featured Genetics Neurology Open Neuroscience Articles

·November 8, 2016·4 min read

The Messenger in Huntington’s Disease

A new study reveals a new molecular mechanism for Huntington's disease.

Featured Genetics Neurology

·January 29, 2018·4 min read

Uncovering the Early Origins of Huntington’s Disease

Rockefeller University researchers reveal Huntington's neurons are much larger than healthy cells.

Featured Genetics Neurology

·February 23, 2018·5 min read

Decoding the Structure of Huntintin

Researchers have decoded the 3D structure of the Huntingtin protein. The discovery may help develop new treatments for Huntington's disease.

Featured Genetics Neurology Open Neuroscience Articles

·July 26, 2018·4 min read

System that Could Reduce Neurodegeneration in Huntington’s Discovered

Researchers have identified a mechanism that may reduce the toxic aggregation of the huntingtin protein. The findings could lead to new treatment options for Huntington's patients.

Featured Genetics Neurology

·September 3, 2018·3 min read

Huntington’s Disease Starts in Childhood

Researchers say the Huntingtin gene affects brain development from an early age, even though most patients do not develop Huntington's disease until later life.

Featured Genetics Neurology Neuroscience

·April 15, 2020·4 min read

When damaged, the adult brain repairs itself by going back to the beginning

Mouse models of corticospinal injuries reveal adult neurons begin a natural regeneration process by reverting back to an embryonic state. The regeneration is sustained with the help of a gene more commonly associated with Huntington's disease.

1 2