dentate gyrus

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dentate gyrus

This shows the location of the sum in the brain

·September 30, 2020·4 min read

Social Novelty Has a Special Place in the Brain

A specialized area of the mouse brain called the SuM specializes in detecting novel experiences. Within this brain area, responses to social novelty, or experiences related to unknown individuals, were segregated from those related to unfamiliar places, before being sent to areas of the brain associated with memory.

Featured Neuroscience

·June 22, 2020·3 min read

Adult-born neurons grow more than their infancy-born counterparts

Neurons created as a result of adult neurogenesis mature for longer and grow larger than those created during infancy. Findings suggest adult-born neurons may have a more powerful function than those created during infancy and may play a critical role in neuroplasticity.

Featured Neuroscience Open Neuroscience Articles

·June 5, 2020·3 min read

Dreaming with purpose

Hippocampal adult-born neurons are responsible for memory consolidation during REM sleep.

Featured Neurology Neuroscience

·May 12, 2020·5 min read

How memory function could be preserved after brain injury

Suppressing TLR4 activity following a traumatic brain injury, such as concussion, reduces excitability, and improves working memory performance up-to a month later.

Featured Neurology Neuroscience

·April 27, 2020·2 min read

Reducing early brain inflammation could slow Alzheimer’s progression

Reducing neuroinflammation in the brain before cognitive impairment becomes apparent can help slow the progression of Alzheimer's disease.

Featured Neuroscience

·February 28, 2020·4 min read

Newly identified cellular trash removal program helps create new neurons

Vimentin, a cellular filament, helps neural stem cells to clear damaged and clumped proteins, assisting in neurogenesis.

Electrophysiology Featured Neuroscience Psychology

·February 19, 2020·5 min read

Altered potassium levels in neurons may cause mood swings in bipolar disorder

Increased potassium currents were responsible for hyperactivity of CA3 neurons. When exposed to potassium channel blockers, the hyperactivity disappeared. However, when exposed to lithium, the drug not only reversed hyperactivity but reduced potassium currents at the same time. The findings strengthen the case that potassium currents play a role in bipolar disorder.

Featured Genetics Neuroscience

·January 20, 2020·2 min read

A new role for neurogenesis

Dentate gyrus neurogenesis acts to replace lost neurons and restore function following massive neuron loss.

This shows Id4 expression in hippocampal neurons

Featured Genetics Neuroscience Open Neuroscience Articles

·August 29, 2019·3 min read

Signal blocks stem cell division in the geriatric brain

A gene regulated called Id4 appears to be a key component in controlling stem cell proliferation.

Featured Neuroscience Open Neuroscience Articles

·August 20, 2019·4 min read

Alzheimer’s drug reverses brain damage from adolescent alcohol exposure

Donepezil, a drug routinely administered to slow cognitive decline in Alzheimer's disease, shows promise in treating damage caused to the brain by adolescent alcohol exposure. The drug reverses neuroinflammation and neuron damage in rats exposed to alcohol during adolescence.