A new study proposes a model for how immature neurons in the dentate gyrus appear to enhance pattern separation.
Dentate gyrus neurogenesis acts to replace lost neurons and restore function following massive neuron loss.
Researchers propose a new theory of memory formation, reporting memory storage does not rely on the strengthening of connection between memory cells, but on the pattern of connections that form within the first few minutes of an event.
Adult born granule cells appear to play a key role in memory encoding, a new study reports.
Neurons created as a result of adult neurogenesis mature for longer and grow larger than those created during infancy. Findings suggest adult-born neurons may have a more powerful function than those created during infancy and may play a critical role in neuroplasticity.
Increased potassium currents were responsible for hyperactivity of CA3 neurons. When exposed to potassium channel blockers, the hyperactivity disappeared. However, when exposed to lithium, the drug not only reversed hyperactivity but reduced potassium currents at the same time. The findings strengthen the case that potassium currents play a role in bipolar disorder.
Researchers report a drug used to slow cognitive decline in Alzheimer's disease may help to reverse memory and learning problems in teens who binge drink.
Donepezil, a drug routinely administered to slow cognitive decline in Alzheimer's disease, shows promise in treating damage caused to the brain by adolescent alcohol exposure. The drug reverses neuroinflammation and neuron damage in rats exposed to alcohol during adolescence.
A new mouse study finds APOE genes, commonly associated with Alzheimer's disease, impairs the development of new neurons in areas of the brain associated with memory.
Researchers report newborn granule cells in the dentate gyrus become less excitable after three weeks. The loss of excitability is crucial for the functioning of mature neurons.
Researchers have discovered a link between anxiety behaviors and PTSD to an increase in myelin in the brain's gray matter.
Although observed in other species, researchers report hippocampal neurogenesis does not persist through adult life in humans. Researchers say human hippocampal neurogenesis is not detectable in the adult brain.
