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chronic pain

This is an illustration of the spinal cord with the cells

·March 4, 2021·4 min read

A New Cell Type Implicated in Chronic Pain and Inflammation

MRC1+ macrophages are dysfunctional in animal models of neuropathic pain. Stimulating the expression of the anti-inflammatory protein CD163 reduced signs of neuroinflammation in the spinal cords of mice with neuropathic pain.

Featured Neurology Pain Psychology

·December 30, 2020·3 min read

Why Opioids Cannot Fix Chronic Pain

Study explores the role the reward system plays in chronic pain, finding emotional and physical pain are bidirectional. Opioids, researchers report, ultimately make things worse.

Featured Neurology Neuroscience Pain

·October 16, 2020·5 min read

The Most Effective Drugs for Common Type of Neuropathic Pain

A study of four drugs to combat chronic neuropathic pain finds Nortriptyline has the highest efficacious percentage and lowest quit rate.

This shows a woman rubbing an inflammed shoulder

Featured Open Neuroscience Articles Pain Psychology

·September 21, 2020·5 min read

Middle-Aged Americans Report More Pain Than the Elderly

Middle-ages adults are reporting more chronic pain symptoms than older generations. Those who are less educated are more likely to report symptoms of chronic pain.

Featured Neurology Neuroscience Pain

·September 6, 2020·3 min read

Why People with Knee Osteoarthritis Experience Different Kinds of Pain

People with osteoarthritis in the knee who report more pain sensations are more likely to suffer constant and unpredictable pain. Researchers identified a potential mechanism in the nervous system that could explain why people experience varying pain patterns associated with knee osteoarthritis.

Featured Neurology Pain

·August 19, 2020·5 min read

Targeting a Chronic Pain Gateway Could Bring Relief

c-Fos accumulates in the nucleus of peripheral nerve cells of mouse models of chronic pain. Researchers identified around 30 existing drugs that appear to target the importin alpha-3-c-Fos pathway to help treat chronic pain.

Featured Neurology Neuroscience Open Neuroscience Articles Pain

·May 19, 2020·5 min read

Mapping the weather patterns affecting people with chronic pain

A new study confirms a link between the severity of symptoms for those with chronic pain and atmospheric weather conditions. Low atmospheric pressure was associated with more severe symptoms of pain.

Featured Neurology Pain

·April 30, 2020·2 min read

A potential treatment for chronic pain

A newly developed peptide called Tat-P4-(C5)2 is targets and only affects nerve changes that pose a problem resulting in chronic pain. Previous studies have also shown the peptide can also reduce addiction.

Featured Neurology Neuroscience Pain

·March 31, 2020·3 min read

New insights into pain signaling in the brain

Study reveals how a neuropeptide called Big Dynorphin binds to the acid-sensing ion channel receptor, causing pain signals to be sent around the body.

Featured Neurology Neuroscience Open Neuroscience Articles Pain

·March 23, 2020·2 min read

Using cannabinoids to treat acute pain

Meta-analysis of previous studies reveals cannabinoid treatments produce a small, but significant reduction in subjective pain scores for sufferers of chronic pain.

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·March 16, 2020·2 min read

A new strategy for the management of inflammatory pain

M2 macrophages can produce various endogenous opioids, such as endorphins, enkephalin, and dynorphin, which activate opioid receptors at the site of inflammation.