Brinker-related transcription regulators play a key role in the formation of nociceptive sensation and could be a new target for pain-relieving medications.
Conolidine, a natural pain killer derived from the pinwheel flower and frequently used in Chinese medicine, interacts with a newly identified opioid receptor that regulates natural opioid peptides produced in the brain.
MRC1+ macrophages are dysfunctional in animal models of neuropathic pain. Stimulating the expression of the anti-inflammatory protein CD163 reduced signs of neuroinflammation in the spinal cords of mice with neuropathic pain.
M2 macrophages can produce various endogenous opioids, such as endorphins, enkephalin, and dynorphin, which activate opioid receptors at the site of inflammation.
Researchers have uncovered a neurological mechanism that may contribute to the reduction of chronic pain.
A newly developed peptide called Tat-P4-(C5)2 is targets and only affects nerve changes that pose a problem resulting in chronic pain. Previous studies have also shown the peptide can also reduce addiction.
A new study reports the number of people reporting chronic pain is rising across every age group and demographic.
Researchers believe the newly understood mechanism could yield insights into more precise future treatments for nerve pain and depression.
Researchers report the brain can suppress feelings of chronic pain when mice are hungry.
Anti-inflammatories may relieve pain in the short term, but blocking inflammation can lead to longer-term chronic pain, a new study reports.
Researchers discover the amygdala is a critical site of action for pain modulation. An existing compound, LY379268, provides pain-relieving effects and helps to reduce anxiety.
Researchers have identified biomarkers in the blood which can help determine the severity of a person's pain level. The findings could help doctors to accurately measure pain and stem the opioid crisis.
