M2 macrophages can produce various endogenous opioids, such as endorphins, enkephalin, and dynorphin, which activate opioid receptors at the site of inflammation.
Intercepting CCL2 with specific antibodies may provide an early intervention for chronic neuropathic pain.
Researchers discover the amygdala is a critical site of action for pain modulation. An existing compound, LY379268, provides pain-relieving effects and helps to reduce anxiety.
Inhibitory inputs to the neural circuit between the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area (VTA) increase when a person is in chronic pain. This alteration is mediated by enhanced corticotropin-releasing factor signaling within the dlBNST, leading to suppression of the mesolimbic dopaminergic system. The result is depressive mood and anhedonia associated with chronic pain.
WaTx, a short protein in the venom of Australian Black Rock scorpions, is helping researchers uncover new information about chronic pain and inflammation.
Blocking the activity of interleukin-1 in mouse models of complex regional pain syndrome (CRPS) helped reverse symptoms. Researchers say patients with CRPS should respond to immune-based treatments which reduce some of the disease features.
Opioids are often prescribed to help those with chronic pain manage sleep problems associated with their condition. New research reports opioids effect on sleep quality is limited and of poor quality. Additionally, opioids can increase the risk of sleep apnea.
A new biomarker for fibromyalgia has been identified in blood samples taken from patients suffering from the condition.
A research group at Hiroshima University observed a potential new target for chronic pain treatment. Further research using this receptor could lead to new, more effective drugs to use in pain-relieving treatment for chronic pain.
Researchers have identified biomarkers in the blood which can help determine the severity of a person's pain level. The findings could help doctors to accurately measure pain and stem the opioid crisis.
Researchers report the sensation and emotional experiences of pain are not the same. A new study reveals neurons in the amygdala responsible for negative emotions associated with chronic pain.
Being in pain and taking illicit substances can lead to a vicious cycle that ultimately worsens and maintains both addiction and pain.
