Conolidine, a natural pain killer derived from the pinwheel flower and frequently used in Chinese medicine, interacts with a newly identified opioid receptor that regulates natural opioid peptides produced in the brain.
Study reveals there is no significant uptick in men who played high school football reporting problems with brain health in middle age compared to their peers who did not play sports. However, ex-football players were more likely to experience sleep problems and be prescribed medications for chronic pain during mid-life.
Genetics may help explain why women are at higher risk for developing chronic pain disorders than men. The study also sheds light on the role the central nervous system plays in the development of chronic pain.
MRC1+ macrophages are dysfunctional in animal models of neuropathic pain. Stimulating the expression of the anti-inflammatory protein CD163 reduced signs of neuroinflammation in the spinal cords of mice with neuropathic pain.
People with osteoarthritis in the knee who report more pain sensations are more likely to suffer constant and unpredictable pain. Researchers identified a potential mechanism in the nervous system that could explain why people experience varying pain patterns associated with knee osteoarthritis.
c-Fos accumulates in the nucleus of peripheral nerve cells of mouse models of chronic pain. Researchers identified around 30 existing drugs that appear to target the importin alpha-3-c-Fos pathway to help treat chronic pain.
A new study confirms a link between the severity of symptoms for those with chronic pain and atmospheric weather conditions. Low atmospheric pressure was associated with more severe symptoms of pain.