chronic pain

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Molecular link between chronic pain and depression revealed

Inhibitory inputs to the neural circuit between the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area (VTA) increase when a person is in chronic pain. This alteration is mediated by enhanced corticotropin-releasing factor signaling within the dlBNST, leading to suppression of the mesolimbic dopaminergic system. The result is depressive mood and anhedonia associated with chronic pain.... Read More...
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Men and Women Remember Pain Differently

A new study reports males seem to remember experiences of pain more clearly, while females are less stress by previous painful experiences. Researchers injected ZIP, a memory blocker into the brains of mice before a painful experience. Following the treatment, the males showed no signs of remembering the pain. The study suggests chronic pain is a problem to the extent you remember it. The findings could help develop new treatments for chronic pain.... Read More...