Middle-ages adults are reporting more chronic pain symptoms than older generations. Those who are less educated are more likely to report symptoms of chronic pain. Read More
People with osteoarthritis in the knee who report more pain sensations are more likely to suffer constant and unpredictable pain. Researchers identified a potential mechanism in the nervous system that could explain why people experience varying pain patterns associated with knee osteoarthritis. Read More
c-Fos accumulates in the nucleus of peripheral nerve cells of mouse models of chronic pain. Researchers identified around 30 existing drugs that appear to target the importin alpha-3-c-Fos pathway to help treat chronic pain. Read More
A new study confirms a link between the severity of symptoms for those with chronic pain and atmospheric weather conditions. Low atmospheric pressure was associated with more severe symptoms of pain. Read More
A newly developed peptide called Tat-P4-(C5)2 is targets and only affects nerve changes that pose a problem resulting in chronic pain. Previous studies have also shown the peptide can also reduce addiction. Read More
Study reveals how a neuropeptide called Big Dynorphin binds to the acid-sensing ion channel receptor, causing pain signals to be sent around the body. Read More
Meta-analysis of previous studies reveals cannabinoid treatments produce a small, but significant reduction in subjective pain scores for sufferers of chronic pain. Read More
M2 macrophages can produce various endogenous opioids, such as endorphins, enkephalin, and dynorphin, which activate opioid receptors at the site of inflammation. Read More
Intercepting CCL2 with specific antibodies may provide an early intervention for chronic neuropathic pain. Read More
Researchers discover the amygdala is a critical site of action for pain modulation. An existing compound, LY379268, provides pain-relieving effects and helps to reduce anxiety. Read More
Inhibitory inputs to the neural circuit between the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area (VTA) increase when a person is in chronic pain. This alteration is mediated by enhanced corticotropin-releasing factor signaling within the dlBNST, leading to suppression of the mesolimbic dopaminergic system. The result is depressive mood and anhedonia associated with chronic pain. Read More
WaTx, a short protein in the venom of Australian Black Rock scorpions, is helping researchers uncover new information about chronic pain and inflammation. Read More
