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chronic pain

·August 20, 2024·3 min read

Molecule Discovery Could Revolutionize Chronic Pain Treatment

Researchers have identified a natural molecule, phosphatidic acid, that reduces the sensitivity of touch-sensing ion channels, providing a promising new avenue for managing chronic pain. By increasing levels of this molecule, cells become less sensitive to touch, which was confirmed through tests on sensory neurons and in mice. This discovery could lead to more targeted and effective treatments for conditions involving inflammatory pain.

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·July 11, 2024·4 min read

New Discovery Links Protein to Chronic Pain

Researchers identified a new role for the PIEZO2 protein in mediating chronic pain hypersensitivity, suggesting a new target for pain relief. The study showed that mutations in PIEZO2 make pain receptors, or nociceptors, highly sensitive to mechanical stimuli, explaining persistent pain. This finding could lead to new analgesics that better address chronic pain by targeting PIEZO2 channels.

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·April 22, 2024·5 min read

Socioeconomic Factors Linked to Chronic Pain

Socioeconomic status, lifestyle, and psychological factors significantly influence the development of chronic musculoskeletal pain after injury. The study found that individuals from lower socioeconomic backgrounds are twice as likely to experience chronic pain, and those with additional risk factors such as smoking, fear of movement, and poor support networks are up to seven times more likely.

Featured Neurology Pain

·April 22, 2023·5 min read

Alcohol Fuels Pain: Study Reveals Link Between Drinking and Chronic Pain

Chronic alcohol consumption can increase sensitivity to pain through two molecular mechanisms. Researchers also identified potential new drug targets for treating alcohol-related chronic pain. Over half of people with alcohol use disorder (AUD) suffer from persistent pain, including alcoholic neuropathy. The study found that alcohol withdrawal could result in neuropathy that was not reversed by re-exposure to alcohol.

This shows a drawing of a man holding his back in pain

Featured Neurology Neuroscience Pain

·March 2, 2023·4 min read

Study Investigates the Source of Back and Joint Pain With the Goal of Reverse Engineering Treatments

Researchers investigate the degeneration process of musculoskeletal tissues that leads to chronic back and joint pain with the hope to translate their findings into new methods to repair tissue damage and ultimately relieve pain.

Featured Neurology Neuroscience Pain

·February 21, 2023·3 min read

Study Finds Link Between Chronic Pain and Dementia

People with chronic pain in multiple parts of the body have a higher risk of developing dementia and accelerated cognitive decline.

This shows a man holding his back in pain

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·January 30, 2023·5 min read

How Ketamine Acts as Antidepressant in Chronic Pain

Chronic pain in mice activates Tiam1 in pyramidal neurons in the anterior cingulate cortex, increasing the number of dendritic spines and inducing synaptic plasticity. Ketamine's antidepressant effect in chronic pain is mediated by the drug blocking Tiam1-dependent maladaptive synaptic plasticity in ACC neurons.

This shows a person holding a dropper and a bottle

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·January 6, 2023·4 min read

Nearly 1/3 of People With Chronic Pain Turn to Cannabis

Study reveals almost one-third of chronic pain patients use cannabis to help manage their symptoms.

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·December 13, 2022·3 min read

A Handy Lesson About Pain and the Brain in Stroke Survivors

Following a stroke, chronic pain can alter body perception and trick the brain into believing the affected hand is a different size. This increases the risk of accidents.

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·December 12, 2022·5 min read

The More TV You Watch, the More Bodily Pain You Have Over Time

Increased daily television viewing is significantly associated with an increase in bodily and chronic pain severity over time, especially for those with Type 2 Diabetes.