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blood-brain barrier

Featured Genetics Neuroscience Psychology

·January 21, 2020·2 min read

Treatment for depression must also restore proper functioning of the blood-brain barrier

In order to treat those with treatment-resistant depression, researchers suggest the integrity of the blood-brain barrier be restored.

This shows the chip, a brain and neurons

Brain Cancer Featured Neurology Neuroscience Neuroscience Videos

·January 4, 2020·4 min read

Buzzing Through the Blood-Brain Barrier

Neuroengineers have developed a new, non-toxic, biodegradable device that can help transport vital medications to the brain by locally opening the blood-brain barrier with ultrasound.

Featured Neurology Neuroscience

·December 29, 2019·7 min read

Drugs that quell brain inflammation reverse dementia

Older mice given anti-inflammatory medication were better able to learn new tasks and became almost as adept at learning as mice half their age.

Featured Neurology Neuroscience

·December 4, 2019·6 min read

Drugs that quell brain inflammation reverse dementia

A synthesized small-molecule drug blocks the TGF-beta receptor in astrocytes and traverses the blood-brain barrier in mice. When administered, the drug lowered receptor activity to that seen in younger mice and reduced inflammation. The aged mice were able to navigate mazes and learn spatial tasks as well as younger mice.

Featured Neuroscience

·October 22, 2019·3 min read

Exposure to environmental PCBs impairs brain function in mice

Polychlorinated biphenyls (PCBs), chemicals commonly used during the 20th century as flame retardants and in industrial products, disrupt the performance of astrocytes, leading to impaired function. Environmental exposure to PCBs could contribute to a range of neurodegenerative diseases.

Featured Neurology Neuroscience Neuroscience Videos Open Neuroscience Articles

·August 28, 2019·6 min read

Robotic thread is designed to slip through the brain’s blood vessels

A newly designed thread-like robot can deliver clot reducing therapies in response to stroke or other brain blockages.

Featured Neurology Neuroscience

·July 12, 2019·3 min read

Healthy blood vessels may be the answer to Alzheimer’s prevention

Damaged capillaries in the brain may set the stage for the development of Alzheimer's disease, years before symptoms appear.

Featured Neurology Neuroscience

·June 6, 2019·5 min read

Ultrasound method restores dopaminergic pathway in brain at Parkinson’s early stages

Using transcranial focused ultrasound in combination with injectable microbubbles, researchers open a pathway through the blood-brain barrier. The technique allows drugs to penetrate the brain and trigger therapeutic effects for those with neurodegenerative diseases.

This shows the BBB created on the organ-chip

Featured Neurology Neuroscience

·June 6, 2019·4 min read

Scientists recreate blood-brain barrier defect outside the body

Using induced pluripotent stem cells derived from patients with neurodegenerative disorders, researcher recreated the blood-brain barrier inside Organ-Chips.

Featured Genetics Neuroscience

·May 14, 2019·8 min read

Blocking protein curbs memory loss in old mice

Blocking VCAM1 increased neurogenesis, and reduced microglia reactivity in the hippocampus of older mice.

Featured Neuroscience Neuroscience Videos

·April 22, 2019·8 min read

New insight into how obesity and insulin resistance can impair cognition

Adora2a mediating signaling in vascular endothelial cells disrupts the blood-brain barrier in obesity. This, researchers report, could be an underlying mechanism for synaptic plasticity and cognitive deficits in those with insulin resistance and obesity.