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blood-brain barrier

·May 8, 2021·3 min read

New MRI Technique Can Detect Early Dysfunction of the Blood-Brain Barrier With Small Vessel Disease

DP-ASL, a new neuroimaging technique may help researchers identify early blood-brain barrier dysfunction associated with SVD.

Electrophysiology Featured Neuroscience Psychology

·April 24, 2021·6 min read

The Immune Link Between a Leaky Blood-Brain Barrier and Schizophrenia

People with schizophrenia and other neuropsychiatric disorders may have a more permissive blood-brain barrier which allows the immune system to become more actively involved in the central nervous system. The resulting inflammation may contribute to the clinical manifestation of psychosis-like symptoms.

Featured Neurology Neuroscience

·March 28, 2021·3 min read

Leaky Blood-Brain Barrier Linked to Brain Tissue Damage in Brain Aging Disease

People with cerebral small vessel damage who also had a leaky blood-brain barrier had more tissue damage after two years than those whose blood-brain barrier was intact.

Featured Genetics Neurology Neuroscience

·March 18, 2021·4 min read

Could Leak in Blood-Brain Barrier Be Cause of Poor Memory?

Researchers investigate the role the blood-brain barrier may play in age-related memory problems.

Featured Genetics Neurology Neuroscience

·March 16, 2021·3 min read

How Sex Differences Play a Role in Neurological Diseases

Separating vascular cell data based on sex helps researchers make new discoveries about why males and females are affected by neurodegenerative diseases differently. Findings point to differences in the blood-brain barrier between males and females.

Featured Neurology Neuroscience

·February 22, 2021·4 min read

Target for Stroke Therapy in Blood-Brain Barrier Discovered

The stroke byproduct acrolein activates the precursor of heparanase, an enzyme that degrades the glycocalyx in the blood-brain barrier.

This shows the outline of a body and a red brain

Featured Genetics Neuroscience

·February 6, 2021·5 min read

Critical Flaw Found in Lab Models of the Human Blood-Brain Barrier

Human brain endothelial cells used to generate lab models of the human blood-brain barrier were missing several key proteins found in natural endothelial cells. The cells had more in common with epithelial, a type of cell not normally found in the brain. The findings put into question over a decade worth of lab-based research on the BBB.

Featured Neurology Neuroscience

·January 1, 2021·5 min read

Nanoparticle Drug-Delivery System Developed to Treat Brain Disorders

A new nanoparticle drug-delivery system resulted in unprecedented siRNA penetration across the intact blood-brain barrier. Researchers say the system could help doctors to treat secondary injuries associated with TBI that can result in Alzheimer's and other neurodegenerative disorders.

Featured Neuroscience

·September 21, 2020·5 min read

Advancing Understanding of Blood-Brain Barrier Health

Study reveals the important role astrocytes play in maintaining blood-brain barrier health.

This shows the drug transportation over the bbb via neurotransmitters

Featured Neuroscience Open Neuroscience Articles

·July 24, 2020·5 min read

Novel Drug Delivery Particles Use Neurotransmitters as a ‘Passport’ Into the Brain

Tufts researchers have developed neurotransmitter-lipid hybrids that help transport therapeutic drugs and gene editing proteins across the blood-brain barrier in mice.

Featured Neurology Open Neuroscience Articles

·June 24, 2020·4 min read

Pulse pressure: A game changer in the fight against dementia

Elevated pulse pressure in blood traveling to the brain causes inflammation, oxidative stress, and apoptosis in the blood-brain barrier that leads to brain damage.

Featured Genetics Neurology Neuroscience

·April 29, 2020·4 min read

APOE4 triggers early breakdowns in the blood-brain barrier

APOE4, a gene implicated as a risk factor for Alzheimer's disease, triggers leaks in the blood-brain barrier. The damage to capillaries APOE4 causes correlates with increased levels of cyclophilin, a protein that causes the inflammation that is a signature of early Alzheimer's.