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blood-brain barrier

Featured Genetics Neurology Neuroscience

·March 16, 2021·3 min read

How Sex Differences Play a Role in Neurological Diseases

Separating vascular cell data based on sex helps researchers make new discoveries about why males and females are affected by neurodegenerative diseases differently. Findings point to differences in the blood-brain barrier between males and females.

Featured Neurology Neuroscience

·February 22, 2021·4 min read

Target for Stroke Therapy in Blood-Brain Barrier Discovered

The stroke byproduct acrolein activates the precursor of heparanase, an enzyme that degrades the glycocalyx in the blood-brain barrier.

This shows the outline of a body and a red brain

Featured Genetics Neuroscience

·February 6, 2021·5 min read

Critical Flaw Found in Lab Models of the Human Blood-Brain Barrier

Human brain endothelial cells used to generate lab models of the human blood-brain barrier were missing several key proteins found in natural endothelial cells. The cells had more in common with epithelial, a type of cell not normally found in the brain. The findings put into question over a decade worth of lab-based research on the BBB.

Featured Neurology Neuroscience

·January 1, 2021·5 min read

Nanoparticle Drug-Delivery System Developed to Treat Brain Disorders

A new nanoparticle drug-delivery system resulted in unprecedented siRNA penetration across the intact blood-brain barrier. Researchers say the system could help doctors to treat secondary injuries associated with TBI that can result in Alzheimer's and other neurodegenerative disorders.

Featured Neuroscience

·September 21, 2020·5 min read

Advancing Understanding of Blood-Brain Barrier Health

Study reveals the important role astrocytes play in maintaining blood-brain barrier health.

This shows the drug transportation over the bbb via neurotransmitters

Featured Neuroscience Open Neuroscience Articles

·July 24, 2020·5 min read

Novel Drug Delivery Particles Use Neurotransmitters as a ‘Passport’ Into the Brain

Tufts researchers have developed neurotransmitter-lipid hybrids that help transport therapeutic drugs and gene editing proteins across the blood-brain barrier in mice.

Featured Neurology Open Neuroscience Articles

·June 24, 2020·4 min read

Pulse pressure: A game changer in the fight against dementia

Elevated pulse pressure in blood traveling to the brain causes inflammation, oxidative stress, and apoptosis in the blood-brain barrier that leads to brain damage.

Featured Genetics Neurology Neuroscience

·April 29, 2020·4 min read

APOE4 triggers early breakdowns in the blood-brain barrier

APOE4, a gene implicated as a risk factor for Alzheimer's disease, triggers leaks in the blood-brain barrier. The damage to capillaries APOE4 causes correlates with increased levels of cyclophilin, a protein that causes the inflammation that is a signature of early Alzheimer's.

Featured Neuroscience

·April 17, 2020·3 min read

New nanocarrier drug delivery technology crosses the blood-brain barrier

Researchers have developed a cyclic peptide that can enhance blood-brain barrier penetration.

Featured Neurology Neuroscience Open Neuroscience Articles

·April 10, 2020·3 min read

More evidence ultrasound can help in battle against Alzheimer’s disease

Combining focused ultrasound with microbubble treatments weakens the connection between blood-brain barrier cells, effectively allowing for better delivery and absorption of drug treatments.

Featured Neuroscience Psychology

·March 14, 2020·5 min read

How chronic stress changes the brain, and what you can do to reverse the damage

Chronic stress can affect a person's health and mental well being. Due to the COVID-19 virus, chronic stress is on the rise worldwide. Researchers examine the general and psychological health implications of chronic stress and suggest some methods we can adopt to keep our stress levels in check.

Featured Genetics Neuroscience Open Neuroscience Articles

·February 28, 2020·3 min read

Our own immune cells damage the integrity of the blood-brain barrier

Microglia initially protects the blood-brain barrier from damage due to systemic inflammation. However, microglia can alter their behavior and increase the permeability of the blood-brain barrier, thus damaging it.