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blood-brain barrier

·July 3, 2026·12 min read

XL20 Crosses Blood-Brain Barrier to Shield ALS Neurons

A new study introduces XL20, an experimental small-molecule drug that crosses the blood-brain barrier to selectively block a toxic region on the TDP-43 protein. This precise mechanism halts neuron death and slows muscle wasting in ALS models while leaving the protein's healthy, vital biological functions completely intact.

Brain Cancer Featured Genetics Neurology Neuroscience

·June 26, 2026·12 min read

Overcoming Endothelial Sorting to Cure Glioblastoma

Researchers present a shift in neuro-nanomedicine, reframing the "protein corona", the layer of blood proteins that coat nanoparticles, as a programmable, five-stage navigation interface capable of guiding therapeutics across the blood-brain barrier via receptor-mediated transcytosis.

Featured Genetics Neuroscience

·June 16, 2026·10 min read

Senescent Cells Are Essential for Building the Brain’s Barriers

Cellular senescence is required for the proper construction of the brain's protective barrier systems.

Featured Genetics Neuroscience

·April 28, 2026·7 min read

One Protein Switches Roles to Build the Brain and Its Blood Vessels

A new study reveals how a single gene manages both brain communication and life-support systems through cellular "editing."

Featured Neurology Neuroscience

·April 23, 2026·8 min read

Freeze-Dried Platelets Combat TBI Brain Swelling and Bleeding

Thrombosomes, a freeze-dried blood product, can stop brain swelling and stabilize leaky blood vessels after traumatic brain injury.

Brain Cancer Featured Neurology Neuroscience

·April 21, 2026·7 min read

Alzheimer’s Brains Share a Genetic Signature with Some Cancers

A study finds that Alzheimer’s is driven by cancer-like mutations in the brain's immune cells, which may enter from the blood and trigger lethal brain inflammation.

This shows a brain and its cardiovascular network.

Featured Neurology Neuroscience

·March 21, 2026·7 min read

How Blood-Brain Barrier Failure Drives CTE in Athletes

A new study identifies a leaky blood-brain barrier as the "missing link" between repetitive head impacts and dementia in retired athletes. Researchers found that this persistent leakage triggers a toxic buildup of proteins, offering a new target for early diagnosis and treatment.

This shows a blood drop with a molecule inside it. Behind is a colorful brain.

Featured Neuroscience

·March 1, 2026·8 min read

New Tech Tracks Living Brain Activity Noninvasively

A window into the living brain. Researchers successfully use "synthetic reporters" to track brain activity and gene expression in primates via a simple blood test.

This shows a brain with cancer cells being blasted away by a laser.

Brain Cancer Featured Neurology Neuroscience

·February 26, 2026·8 min read

Laser Heat Unlocks Immunotherapy for Brain Cancer

Scientists use laser heat to "unseal" the blood-brain barrier, allowing immunotherapy to achieve record-breaking survival rates for brain cancer.

Autism Featured Genetics Neuroscience

·February 25, 2026·10 min read

Overactive MicroRNA Triggers Leaky Brain in Rett Syndrome

It’s not just the neurons. Scientists discover that Rett syndrome causes the brain’s "plumbing" to leak, disrupting the blood-brain barrier and hijacking neural activity.

Featured Neurology Neuroscience

·September 29, 2025·6 min read

Alzheimer’s Study Finds Blood-Brain Barrier Largely Intact

A new study suggests that the blood-brain barrier (BBB) remains intact in a widely used mouse model of Alzheimer’s disease. Using a tracer molecule and advanced analysis, scientists found no significant leakage across brain regions, even near amyloid plaques.

Featured Neurology Neuroscience

·August 12, 2025·4 min read

Why the Blood-Brain Barrier Weakens With Age

A new study has uncovered why the blood-brain barrier — the brain’s protective shield — becomes leakier with age, potentially triggering memory decline. Researchers identified that proteins N-cadherin and occludin, which help maintain the barrier’s tight junctions, decrease over time.