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          APP

          This shows neurons.
          AutismFeaturedGeneticsNeurologyNeuroscience
          ·May 15, 2024·4 min read

          CNTN4 Protein’s Role in Autism and Alzheimer’s Unveiled

          A new study reveals the crucial role of the protein Contactin-4 (CNTN4) in neuron development, impacting both neurodevelopmental disorders and Alzheimer's disease. Researchers found that CNTN4, linked to autism, interacts with the Alzheimer-related protein APP, affecting neuron growth in the brain's cortex.
          Read More
          This shows APP.
          FeaturedNeurologyNeuroscience
          ·March 14, 2024·6 min read

          Unraveling Alzheimer’s: A Novel Mechanical Perspective on Amyloid Precursor Protein’s Role

          groundbreaking study introduces a novel hypothesis that Amyloid Precursor Protein (APP), known for its role in Alzheimer's disease (AD), is crucial for the mechanical integrity of synapses through its interaction with talin, a synaptic scaffold protein. It proposes that the misprocessing of APP disrupts mechanical signaling pathways, leading to synaptic degeneration and memory loss, thereby contributing to the progression of AD.
          Read More
          This is a diagram from the study
          FeaturedNeurologyNeuroscience
          ·August 18, 2021·5 min read

          Key Mechanisms Behind Synapse Degeneration in Alzheimer’s Brain Discovered

          Study identifies the main components driving amyloid beta-associated synaptic degeneration.
          Read More
          This shows neurons
          FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology
          ·May 19, 2021·4 min read

          Alzheimer Protein App Regulates Learning and Social Behavior in the Healthy Brain

          APP, a protein commonly associated with Alzheimer's disease, plays a vital role in learning, memory, and social behavior in the developing brain, a new mouse study finds.
          Read More
          This shows AB plaques surrounded by microglia
          FeaturedGeneticsNeurologyNeuroscience
          ·April 16, 2021·5 min read

          Some Alzheimer’s Plaques May Be Protective, Not Destructive

          Microglia creates dense-core plaques which help to clear away more wispy plaques from neurons, preventing cell death. Findings suggest the dense-core plaques play a defensive role in protecting the brain from the ravages of neurodegenerative diseases, such as Alzheimer's.
          Read More
          This shows an old woman's hands
          FeaturedGeneticsNeurologyNeuroscienceOpen Neuroscience Articles
          ·December 11, 2019·4 min read

          Your genes aren’t the only factor dictating Alzheimer’s risk

          While genetics may increase your risk of developing dementia, other factors such as lifestyle and environment may play a key role in the development and progression of Alzheimer's disease.
          Read More
          This shows microglia
          FeaturedNeurologyNeuroscienceOpen Neuroscience Articles
          ·September 27, 2019·8 min read

          Common nutrient supplement choline may hold the answers to combating Alzheimer’s

          Taking dietary choline supplements may help to protect the brain from Alzheimer's disease. Choline reduces the activation of microglia which, when overactivated, contribute to neuroinflammation and apoptosis associated with Alzheimer's. Choline also helps block the production of amyloid plaques.
          Read More
          This shows a brain
          FeaturedGeneticsNeurologyNeuroscience
          ·August 23, 2019·6 min read

          How ‘Australian’ mutation leads to Alzheimer’s disease

          The 'Australian' familial genetic mutation, L723P, causes local unfolding of the C-terminal turn of the APP TM dominant helix. The findings suggest a mechanism of pathogenesis associated with the mutation.
          Read More
          This shows neurons
          FeaturedNeurologyNeuroscienceOpen Neuroscience Articles
          ·June 14, 2019·4 min read

          Modified protein can prevent Alzheimer’s disease in mice

          Researchers injected a modified segment of the amyloid precursor protein into mouse models of Alzheimer's disease. The treatment appeared to reverse a number of the cognitive and memory problems associated with the neurodegenerative disease.
          Read More
          This shows the outline of a head
          FeaturedNeurologyNeuroscience
          ·May 28, 2019·6 min read

          High LDL cholesterol linked to early-onset Alzheimer’s

          Elevated levels of LDL cholesterol has been linked to an increased risk of early-onset Alzheimer's disease, in those with and without a genetic risk factor. This suggests cholesterol could be an independent risk factor for dementia. Additionally, researchers identified a potential new genetic risk factor for early-onset Alzheimer's, a rare variant of the APOB gene.
          Read More
          This shows a neuron
          FeaturedNeurologyNeuroscience
          ·April 23, 2019·4 min read

          Scientists propose new theory on Alzheimer’s, amyloid connection

          Study finds a 'peculiar association' between amyloid precursor protein and cholesterol in the cell membrane of synapses. Amyloid precursor protein may contribute to cholesterol deficiency, triggering neurodegeneration in Alzheimer's disease.
          Read More
          graph
          FeaturedGeneticsNeurology
          ·February 28, 2019·5 min read

          Data Sharing Uncovers Five New Risk Genes For Alzheimer’s

          A new study of the genetic data from over 94,000 people with Alzheimer's has identified five new risk genes, as well as confirmed 20 other known genes in the disease.
          Read More
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          This shows a brain and banana.

          Color Knowledge Tied to Language-Visual Brain Circuitry

          This shows two heads and a brain.

          Depression May Signal Chronic Pain Years Before It Starts

          This shows a brain.

          Body’s Own Cannabinoids May Help Control Trauma-Linked Fear

          This shows a brain.

          Brain’s Gatekeepers Remember Signals to Shape Long-Term Memory

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