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Autism Featured Genetics Neurology Neuroscience

·May 15, 2024·4 min read

CNTN4 Protein’s Role in Autism and Alzheimer’s Unveiled

A new study reveals the crucial role of the protein Contactin-4 (CNTN4) in neuron development, impacting both neurodevelopmental disorders and Alzheimer's disease. Researchers found that CNTN4, linked to autism, interacts with the Alzheimer-related protein APP, affecting neuron growth in the brain's cortex.

Featured Neurology Neuroscience

·March 14, 2024·6 min read

Unraveling Alzheimer’s: A Novel Mechanical Perspective on Amyloid Precursor Protein’s Role

groundbreaking study introduces a novel hypothesis that Amyloid Precursor Protein (APP), known for its role in Alzheimer's disease (AD), is crucial for the mechanical integrity of synapses through its interaction with talin, a synaptic scaffold protein. It proposes that the misprocessing of APP disrupts mechanical signaling pathways, leading to synaptic degeneration and memory loss, thereby contributing to the progression of AD.

Featured Neurology Neuroscience

·August 18, 2021·5 min read

Key Mechanisms Behind Synapse Degeneration in Alzheimer’s Brain Discovered

Study identifies the main components driving amyloid beta-associated synaptic degeneration.

Featured Neuroscience Open Neuroscience Articles Psychology

·May 19, 2021·4 min read

Alzheimer Protein App Regulates Learning and Social Behavior in the Healthy Brain

APP, a protein commonly associated with Alzheimer's disease, plays a vital role in learning, memory, and social behavior in the developing brain, a new mouse study finds.

This shows AB plaques surrounded by microglia

Featured Genetics Neurology Neuroscience

·April 16, 2021·5 min read

Some Alzheimer’s Plaques May Be Protective, Not Destructive

Microglia creates dense-core plaques which help to clear away more wispy plaques from neurons, preventing cell death. Findings suggest the dense-core plaques play a defensive role in protecting the brain from the ravages of neurodegenerative diseases, such as Alzheimer's.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·December 11, 2019·4 min read

Your genes aren’t the only factor dictating Alzheimer’s risk

While genetics may increase your risk of developing dementia, other factors such as lifestyle and environment may play a key role in the development and progression of Alzheimer's disease.

Featured Neurology Neuroscience Open Neuroscience Articles

·September 27, 2019·8 min read

Common nutrient supplement choline may hold the answers to combating Alzheimer’s

Taking dietary choline supplements may help to protect the brain from Alzheimer's disease. Choline reduces the activation of microglia which, when overactivated, contribute to neuroinflammation and apoptosis associated with Alzheimer's. Choline also helps block the production of amyloid plaques.

Featured Genetics Neurology Neuroscience

·August 23, 2019·6 min read

How ‘Australian’ mutation leads to Alzheimer’s disease

The 'Australian' familial genetic mutation, L723P, causes local unfolding of the C-terminal turn of the APP TM dominant helix. The findings suggest a mechanism of pathogenesis associated with the mutation.

Featured Neurology Neuroscience Open Neuroscience Articles

·June 14, 2019·4 min read

Modified protein can prevent Alzheimer’s disease in mice

Researchers injected a modified segment of the amyloid precursor protein into mouse models of Alzheimer's disease. The treatment appeared to reverse a number of the cognitive and memory problems associated with the neurodegenerative disease.

Featured Neurology Neuroscience

·May 28, 2019·6 min read

High LDL cholesterol linked to early-onset Alzheimer’s

Elevated levels of LDL cholesterol has been linked to an increased risk of early-onset Alzheimer's disease, in those with and without a genetic risk factor. This suggests cholesterol could be an independent risk factor for dementia. Additionally, researchers identified a potential new genetic risk factor for early-onset Alzheimer's, a rare variant of the APOB gene.

Featured Neurology Neuroscience

·April 23, 2019·4 min read

Scientists propose new theory on Alzheimer’s, amyloid connection

Study finds a 'peculiar association' between amyloid precursor protein and cholesterol in the cell membrane of synapses. Amyloid precursor protein may contribute to cholesterol deficiency, triggering neurodegeneration in Alzheimer's disease.

Featured Genetics Neurology

·February 28, 2019·5 min read

Data Sharing Uncovers Five New Risk Genes For Alzheimer’s

A new study of the genetic data from over 94,000 people with Alzheimer's has identified five new risk genes, as well as confirmed 20 other known genes in the disease.