While genetics may increase your risk of developing dementia, other factors such as lifestyle and environment may play a key role in the development and progression of Alzheimer's disease. Read More
Taking dietary choline supplements may help to protect the brain from Alzheimer's disease. Choline reduces the activation of microglia which, when overactivated, contribute to neuroinflammation and apoptosis associated with Alzheimer's. Choline also helps block the production of amyloid plaques. Read More
The 'Australian' familial genetic mutation, L723P, causes local unfolding of the C-terminal turn of the APP TM dominant helix. The findings suggest a mechanism of pathogenesis associated with the mutation. Read More
Researchers injected a modified segment of the amyloid precursor protein into mouse models of Alzheimer's disease. The treatment appeared to reverse a number of the cognitive and memory problems associated with the neurodegenerative disease. Read More
Elevated levels of LDL cholesterol has been linked to an increased risk of early-onset Alzheimer's disease, in those with and without a genetic risk factor. This suggests cholesterol could be an independent risk factor for dementia. Additionally, researchers identified a potential new genetic risk factor for early-onset Alzheimer's, a rare variant of the APOB gene. Read More
Study finds a 'peculiar association' between amyloid precursor protein and cholesterol in the cell membrane of synapses. Amyloid precursor protein may contribute to cholesterol deficiency, triggering neurodegeneration in Alzheimer's disease. Read More
A new study of the genetic data from over 94,000 people with Alzheimer's has identified five new risk genes, as well as confirmed 20 other known genes in the disease. Read More
Researchers identified gene recombination in neurons that produces new gene variants in the brains of those with Alzheimer's disease. The findings, researchers say, may point to a potential near term treatment for the neurodegenerative disease. Read More
Researchers report specific alterations in signaling circuits associated with memory can induce an abnormal response in neurons, which is linked to the aging process and cognitive decline. Read More
Researchers report extra copies of genes on chromosome 21 increase Alzheimer's like pathology and cognitive impairment in mouse models of Down syndrome. The findings provide insight into early onset Alzheimer's in those with Down syndrome. Read More
··10 min read
Researchers provide evidence that certain species of human herpesvirus contribute to the development of Alzheimer's disease. The study reports high levels of human herpesvirus 6A and 7 were found in brain samples showing signs of Alzheimer's neuropathology. The findings offer hints of the viral mechanisms that could trigger or exacerbate AD. Read More
Researchers investigate the role the BMI1 gene plays in the onset and development of Alzheimer's disease. The study reports the loss of BMI1 triggers and increased production of amyloid beta and decreases neural ability to eliminate the protein. Read More
