AutismFeaturedGeneticsNeurologyNeuroscience·May 15, 2024·4 min readCNTN4 Protein’s Role in Autism and Alzheimer’s UnveiledA new study reveals the crucial role of the protein Contactin-4 (CNTN4) in neuron development, impacting both neurodevelopmental disorders and Alzheimer's disease. Researchers found that CNTN4, linked to autism, interacts with the Alzheimer-related protein APP, affecting neuron growth in the brain's cortex.Read More
FeaturedNeurologyNeuroscience·March 14, 2024·6 min readUnraveling Alzheimer’s: A Novel Mechanical Perspective on Amyloid Precursor Protein’s Rolegroundbreaking study introduces a novel hypothesis that Amyloid Precursor Protein (APP), known for its role in Alzheimer's disease (AD), is crucial for the mechanical integrity of synapses through its interaction with talin, a synaptic scaffold protein. It proposes that the misprocessing of APP disrupts mechanical signaling pathways, leading to synaptic degeneration and memory loss, thereby contributing to the progression of AD.Read More
FeaturedNeurologyNeuroscience·August 18, 2021·5 min readKey Mechanisms Behind Synapse Degeneration in Alzheimer’s Brain DiscoveredStudy identifies the main components driving amyloid beta-associated synaptic degeneration.Read More
FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology·May 19, 2021·4 min readAlzheimer Protein App Regulates Learning and Social Behavior in the Healthy BrainAPP, a protein commonly associated with Alzheimer's disease, plays a vital role in learning, memory, and social behavior in the developing brain, a new mouse study finds.Read More
FeaturedGeneticsNeurologyNeuroscience·April 16, 2021·5 min readSome Alzheimer’s Plaques May Be Protective, Not DestructiveMicroglia creates dense-core plaques which help to clear away more wispy plaques from neurons, preventing cell death. Findings suggest the dense-core plaques play a defensive role in protecting the brain from the ravages of neurodegenerative diseases, such as Alzheimer's.Read More
FeaturedGeneticsNeurologyNeuroscienceOpen Neuroscience Articles·December 11, 2019·4 min readYour genes aren’t the only factor dictating Alzheimer’s riskWhile genetics may increase your risk of developing dementia, other factors such as lifestyle and environment may play a key role in the development and progression of Alzheimer's disease.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·September 27, 2019·8 min readCommon nutrient supplement choline may hold the answers to combating Alzheimer’sTaking dietary choline supplements may help to protect the brain from Alzheimer's disease. Choline reduces the activation of microglia which, when overactivated, contribute to neuroinflammation and apoptosis associated with Alzheimer's. Choline also helps block the production of amyloid plaques.Read More
FeaturedGeneticsNeurologyNeuroscience·August 23, 2019·6 min readHow ‘Australian’ mutation leads to Alzheimer’s diseaseThe 'Australian' familial genetic mutation, L723P, causes local unfolding of the C-terminal turn of the APP TM dominant helix. The findings suggest a mechanism of pathogenesis associated with the mutation.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·June 14, 2019·4 min readModified protein can prevent Alzheimer’s disease in miceResearchers injected a modified segment of the amyloid precursor protein into mouse models of Alzheimer's disease. The treatment appeared to reverse a number of the cognitive and memory problems associated with the neurodegenerative disease.Read More
FeaturedNeurologyNeuroscience·May 28, 2019·6 min readHigh LDL cholesterol linked to early-onset Alzheimer’sElevated levels of LDL cholesterol has been linked to an increased risk of early-onset Alzheimer's disease, in those with and without a genetic risk factor. This suggests cholesterol could be an independent risk factor for dementia. Additionally, researchers identified a potential new genetic risk factor for early-onset Alzheimer's, a rare variant of the APOB gene.Read More
FeaturedNeurologyNeuroscience·April 23, 2019·4 min readScientists propose new theory on Alzheimer’s, amyloid connectionStudy finds a 'peculiar association' between amyloid precursor protein and cholesterol in the cell membrane of synapses. Amyloid precursor protein may contribute to cholesterol deficiency, triggering neurodegeneration in Alzheimer's disease.Read More
FeaturedGeneticsNeurology·February 28, 2019·5 min readData Sharing Uncovers Five New Risk Genes For Alzheimer’sA new study of the genetic data from over 94,000 people with Alzheimer's has identified five new risk genes, as well as confirmed 20 other known genes in the disease.Read More