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This shows AB plaques surrounded by microglia

Featured Genetics Neurology Neuroscience

·April 16, 2021·5 min read

Some Alzheimer’s Plaques May Be Protective, Not Destructive

Microglia creates dense-core plaques which help to clear away more wispy plaques from neurons, preventing cell death. Findings suggest the dense-core plaques play a defensive role in protecting the brain from the ravages of neurodegenerative diseases, such as Alzheimer's.

The image shows a normal brain slice and a brain slice of with severe AD.

Featured Genetics

·September 24, 2013·4 min read

Study Confirms that Rare Mutations Increase Risk of Late Onset Alzheimer’s Disease

Researchers have identified and validated two rare gene mutations which could be a cause for late onset Alzheimer's disease.

a brain with a drawing of a viral vector on top

Featured Genetics Neurology Open Neuroscience Articles

·June 21, 2018·10 min read

Viral Connection to Alzheimer’s: Herpes Virus Implicated in Alzheimer’s Disease

Researchers provide evidence that certain species of human herpesvirus contribute to the development of Alzheimer's disease. The study reports high levels of human herpesvirus 6A and 7 were found in brain samples showing signs of Alzheimer's neuropathology. The findings offer hints of the viral mechanisms that could trigger or exacerbate AD.

Featured Neurology

·October 4, 2012·3 min read

A Molecular Scissor Related to Alzheimer’s Disease

An international research team revealed the atomic‐level structure of the human peptidase enzyme meprin β (beta).

Featured Genetics Neurology Neuroscience

·August 23, 2019·6 min read

How ‘Australian’ mutation leads to Alzheimer’s disease

The 'Australian' familial genetic mutation, L723P, causes local unfolding of the C-terminal turn of the APP TM dominant helix. The findings suggest a mechanism of pathogenesis associated with the mutation.

Featured Neuroscience Open Neuroscience Articles

·June 27, 2018·4 min read

New Mechanism Involved in Age Related Memory Loss Discovered

Researchers report specific alterations in signaling circuits associated with memory can induce an abnormal response in neurons, which is linked to the aging process and cognitive decline.

Featured Neurology Neuroscience Open Neuroscience Articles

·October 18, 2017·5 min read

One Step Closer Toward a Treatment for Alzheimer’s Disease?

Researchers have developed a new class of drugs that may be more precise at blocking the production of toxic forms of amyloid beta.

Featured Genetics Neurology

·July 19, 2017·4 min read

Steering an Enzyme’s ‘Scissors’ Shows Potential for Stopping Alzheimer’s

Researchers at UBC believe they have identified a method that could help stop Alzheimer's disease in its tracks.

This image shows stained slices from the study.

Featured Neurology Open Neuroscience Articles

·April 29, 2015·5 min read

Amyloid Beta Production Blocked in Mouse Model of Alzheimer’s

Findings promising as a potential early therapeutic intervention for AD.

Featured Neurology Neuroscience Open Neuroscience Articles

·June 14, 2019·4 min read

Modified protein can prevent Alzheimer’s disease in mice

Researchers injected a modified segment of the amyloid precursor protein into mouse models of Alzheimer's disease. The treatment appeared to reverse a number of the cognitive and memory problems associated with the neurodegenerative disease.

Featured Neurology

·April 11, 2016·2 min read

Dysfunctional Endosomes Precede Hallmarks of Alzheimer’s Disease

Abnormalities are linked to axonal dysfunctions and neurodegeneration in Alzheimer's disease and Down syndrome, a new study reports.

Featured Genetics Neurology Psychology

·June 26, 2018·5 min read

Genes Linking Alzheimer’s to Down Syndrome Discovered

Researchers report extra copies of genes on chromosome 21 increase Alzheimer's like pathology and cognitive impairment in mouse models of Down syndrome. The findings provide insight into early onset Alzheimer's in those with Down syndrome.

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