A new study reports the dementia associated with Down syndrome involves defects in GSAP, which also malfunctions in Alzheimer's disease.
The 'Australian' familial genetic mutation, L723P, causes local unfolding of the C-terminal turn of the APP TM dominant helix. The findings suggest a mechanism of pathogenesis associated with the mutation.
Researchers have identified key molecular pathways which lead to late-onset Alzheimer's disease. The study presents a new approach to Alzheimer's research and highlights several potential drug targets.
Researchers have identified a uniquely identifiable odor signature in urine that appears prior to the development of Alzheimer's related brain pathologies.
Study identifies the main components driving amyloid beta-associated synaptic degeneration.
In animal studies, researchers have identified a compound which reduces amyloid beta proteins by more than half.
According to a new Journal of Alzheimer's Disease study, common genetic variants in amyloid precursor protein are associated with fluid intelligence in children.
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Researchers provide evidence that certain species of human herpesvirus contribute to the development of Alzheimer's disease. The study reports high levels of human herpesvirus 6A and 7 were found in brain samples showing signs of Alzheimer's neuropathology. The findings offer hints of the viral mechanisms that could trigger or exacerbate AD.
Researchers report extra copies of genes on chromosome 21 increase Alzheimer's like pathology and cognitive impairment in mouse models of Down syndrome. The findings provide insight into early onset Alzheimer's in those with Down syndrome.
New technology allows researchers to produce images that predate the formation of amyloid beta in the brain. The findings have prompted researchers to suggest stabilizing the protein, rather than attempting to limit it, in order to reduce Alzheimer's symptoms.
A new study provides insight into the link between ApoE4 and SirT1, an anti-aging protein found is resveratrol.