Study identifies the main components driving amyloid beta-associated synaptic degeneration.
APP, a protein commonly associated with Alzheimer's disease, plays a vital role in learning, memory, and social behavior in the developing brain, a new mouse study finds.
Microglia creates dense-core plaques which help to clear away more wispy plaques from neurons, preventing cell death. Findings suggest the dense-core plaques play a defensive role in protecting the brain from the ravages of neurodegenerative diseases, such as Alzheimer's.
While genetics may increase your risk of developing dementia, other factors such as lifestyle and environment may play a key role in the development and progression of Alzheimer's disease.
Taking dietary choline supplements may help to protect the brain from Alzheimer's disease. Choline reduces the activation of microglia which, when overactivated, contribute to neuroinflammation and apoptosis associated with Alzheimer's. Choline also helps block the production of amyloid plaques.
The 'Australian' familial genetic mutation, L723P, causes local unfolding of the C-terminal turn of the APP TM dominant helix. The findings suggest a mechanism of pathogenesis associated with the mutation.
Researchers injected a modified segment of the amyloid precursor protein into mouse models of Alzheimer's disease. The treatment appeared to reverse a number of the cognitive and memory problems associated with the neurodegenerative disease.
Elevated levels of LDL cholesterol has been linked to an increased risk of early-onset Alzheimer's disease, in those with and without a genetic risk factor. This suggests cholesterol could be an independent risk factor for dementia. Additionally, researchers identified a potential new genetic risk factor for early-onset Alzheimer's, a rare variant of the APOB gene.
Study finds a 'peculiar association' between amyloid precursor protein and cholesterol in the cell membrane of synapses. Amyloid precursor protein may contribute to cholesterol deficiency, triggering neurodegeneration in Alzheimer's disease.
A new study of the genetic data from over 94,000 people with Alzheimer's has identified five new risk genes, as well as confirmed 20 other known genes in the disease.
Researchers identified gene recombination in neurons that produces new gene variants in the brains of those with Alzheimer's disease. The findings, researchers say, may point to a potential near term treatment for the neurodegenerative disease.
Researchers report specific alterations in signaling circuits associated with memory can induce an abnormal response in neurons, which is linked to the aging process and cognitive decline.