amyotrophic lateral sclerosis

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amyotrophic lateral sclerosis

Featured Genetics Neurology Neuroscience

·February 11, 2023·6 min read

Large-Scale Generation of Muscle-Controlling Nerve Cells From ALS Patients

A person's sex is one of the main drivers of altered gene expression in motor neurons, regardless of whether they were derived from patients diagnosed with ALS. Male ALS stem cells generated significantly more motor neurons than the control group, however, this was not seen in female samples.

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Featured Neuroscience

·February 4, 2023·5 min read

Soft Robotic Wearable Restores Arm Function for People With Amyotrophic Lateral Sclerosis

A newly designed soft robotic wearable is able to provide significant upper arm and shoulder support and improved mobility for those with ALS.

Featured Neurology Neuroscience

·February 3, 2023·3 min read

Features That May Make Motor Neurons Vulnerable to ALS

Study links motor neurons' large cell size and supporting structures with genes that underly vulnerability to degeneration associated with ALS.

Featured Neurology Neuroscience

·December 20, 2022·4 min read

A Protective Probiotic for ALS Found

Lacticaseibacillus rhamnosus HA-114, a non-commercial probiotic reduces neurodegeneration and has neuroprotective effects in lab models of ALS.

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Featured Neurology Neuroscience

·October 16, 2022·4 min read

Speech as a New Diagnostic Tool in ALS and FTD

With the help of AI, researchers are developing digital biomarkers that use speech data to identify ALS and frontotemporal dementia.

Featured Neurology Neuroscience

·September 18, 2022·4 min read

ALS Risk Higher Among Production Workers, Those Exposed to Metals, Volatile Compounds on Job

Those working in production occupations, especially those exposed to volatile organic compounds, metals, combustion pollutants, and particulate matter have a higher risk of developing ALS.

Featured Genetics Neurology Neuroscience

·June 22, 2022·4 min read

ALS May Be Linked to Both the Immune and Central Nervous Systems

Researchers discovered both immune system and central nervous system dysfunction in animal models and people with ALS4, a genetic, juvenile, and slow-progressing form of ALS.

Featured Neurology Neuroscience Open Neuroscience Articles

·March 18, 2022·5 min read

Could There Be a Link Between the Enteric Neurons, Gut Microbiome and ALS?

Study reveals an association between intestinal inflammation and the gut microbiome in the development and progression of ALS.

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Featured Neurology Neuroscience

·March 10, 2022·4 min read

Motor Neuron Toxin Associated With ALS Identified

PolyP, an inorganic polyphosphate released by astrocytes in people with ALS and frontotemporal dementia contributes to the signature motor neuron death associated with the disease pathologies.

Featured Genetics Neurology Neuroscience

·February 28, 2022·4 min read

A New Molecular Pathway Shared by Two Neurodegenerative Disorders Discovered

Mislocalization of the TDP-43 protein alters the genetic instructions for UNC13A. The findings provide a potential new therapeutic target for the treatment of ALS and frontotemporal dementia.

Featured Neurology Neuroscience Open Neuroscience Articles

·January 28, 2022·4 min read

Simple and Reliable ALS Diagnosis With Blood Tests

Measuring the level of neurofilaments in the blood may be a reliable biomarker for the early diagnosis of ALS.

Featured Genetics Neurology Neuroscience

·January 19, 2022·6 min read

Astrocyte Studies Reveal Harmful Changes in Amyotrophic Lateral Sclerosis

In patients with ALS, astrocytes within the brain become pro-inflammatory and tend to lose their protective function, resulting in changes in the ability to uptake glutamate.

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