New insight into motor neuron death mechanisms could be a step toward ALS treatment
When a motor neuron-specific pool of heat shock protein 90 (Hps90) was inhibited, motor neuron apoptosis was triggered.... Read More...
amyotrophic lateral sclerosis
Gut microbes may affect the course of ALS
Researchers have isolated a molecule that may be under-produced in the gut of those with ALS. Using mouse models of the disease, researchers identified 11 microbial strains that became altered as the disease progressed, or before the development of symptoms. ... Read More...
Are the ‘viral’ agents of MS, ALS and schizophrenia buried in our genome?
Retroviruses may be a missing causal link in diseases like ALS, multiple sclerosis and schizophrenia.... Read More...
To cure brain diseases, neuroscientists must collaborate: That’s why I’m giving my data away
Open sharing of scientific data and standard methods will allow researchers to collaborate on projects and accelerate understanding of neurodegenerative diseases.... Read More...
Copper compound shows further potential as therapy for slowing ALS
Treatment with copper-ATSM helped mouse models retain behavioral performance and prevented extensive motor neuron degeneration and microglial activation associated with ALS. ... Read More...
Weight gain and high BMI linked to lower risk of ALS
While being overweight may be bad for your general health, researchers discovered an association with higher body mass index (BMI) and a reduced risk of developing ALS. Those with a BMI considered to be in the obese range had a 31% reduced risk of developing ALS, while those considered overweight had an 18% lower risk. ... Read More...
ALS patients may benefit from more glucose
Using fruit fly models of ALS, researchers discover neurons given glucose transform the power source into energy, enabling them to survive longer and function better. ... Read More...
Five Australian patients to trial new brain reading device to help speech and movement
A minimally invasive brain implant is to be tested on humans for the first time. The device, named Stentrode, will be placed in blood vessels in the motor cortex, and researchers believe it will help improve movement and speech for those with a range of neurological disorders.... Read More...
How ALS progresses on genetic and cellular level revealed by high-res spinal cord study
Changes in gene expression help researchers identify ALS associated pathways and establish the key drivers of motor neuron degeneration in the disease.... Read More...
Guardians of the Synapse: A New Role For Schwann Cells Identified
Schwann cells help protect nerves against blood clotting factors that cause degeneration, researchers report. ... Read More...
Pesticide Exposure Contributes to Faster ALS Progression
Researchers report exposure to common pesticides, such as PCBs, can accelerate the progression of ALS.... Read More...
Can a Nerve Injury Trigger ALS?
A new study reveals peripheral nerve damage may trigger the onset and spread of ALS in mouse models of the neurodegenerative disease.... Read More...