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amyotrophic lateral sclerosis

Featured Genetics Neurology Neuroscience

·July 12, 2024·6 min read

New ALS-Causing Gene Discovered

Researchers identified a new mutation in the ARPP21 gene linked to ALS. The mutation was found in 10 ALS patients from 7 unrelated families in La Rioja, Spain. This discovery could improve ALS diagnosis and open avenues for personalized therapies. The findings emphasize the importance of genetic research in understanding and treating neurodegenerative diseases.

Featured Neurology Neuroscience

·June 21, 2024·4 min read

ALS Study Reveals Subtypes and Promising Drug Target

Researchers identified four subtypes of ALS, which could lead to more effective, personalized treatments. The study also highlights significant molecular differences between men and women with ALS. A promising drug target, the MAPK signaling pathway, was identified, which could lead to new therapies. These findings bring us closer to understanding and treating this fatal neurodegenerative disease.

Featured Genetics Neurology Neuroscience

·April 27, 2024·7 min read

Gene Therapy Slows ALS Progression

Researchers made a significant breakthrough in ALS treatment using a new gene therapy, marking a notable slow in disease progression for a patient with an aggressive form of ALS. The patient, treated since early 2020, has maintained much of their physical and social abilities, exceeding typical life expectancy and functionality projections for their condition.

Featured Neurology Neuroscience

·April 11, 2024·5 min read

Paints and Pesticides Linked to ALS Risk

A new study reveals a possible link between storing chemicals in home garages and an increased risk of developing amyotrophic lateral sclerosis (ALS). Researchers identified significant associations between ALS risk and the residential storage of volatile chemicals such as pesticides, gasoline, and paint.

Featured Genetics Neurology Neuroscience

·February 11, 2023·6 min read

Large-Scale Generation of Muscle-Controlling Nerve Cells From ALS Patients

A person's sex is one of the main drivers of altered gene expression in motor neurons, regardless of whether they were derived from patients diagnosed with ALS. Male ALS stem cells generated significantly more motor neurons than the control group, however, this was not seen in female samples.

This shows a person demonstrating the vest with the robotic attachment

Featured Neuroscience

·February 4, 2023·5 min read

Soft Robotic Wearable Restores Arm Function for People With Amyotrophic Lateral Sclerosis

A newly designed soft robotic wearable is able to provide significant upper arm and shoulder support and improved mobility for those with ALS.

Featured Neurology Neuroscience

·February 3, 2023·3 min read

Features That May Make Motor Neurons Vulnerable to ALS

Study links motor neurons' large cell size and supporting structures with genes that underly vulnerability to degeneration associated with ALS.

Featured Neurology Neuroscience

·December 20, 2022·4 min read

A Protective Probiotic for ALS Found

Lacticaseibacillus rhamnosus HA-114, a non-commercial probiotic reduces neurodegeneration and has neuroprotective effects in lab models of ALS.

This shows the outline of a head and a brain

Featured Neurology Neuroscience

·October 16, 2022·4 min read

Speech as a New Diagnostic Tool in ALS and FTD

With the help of AI, researchers are developing digital biomarkers that use speech data to identify ALS and frontotemporal dementia.

Featured Neurology Neuroscience

·September 18, 2022·4 min read

ALS Risk Higher Among Production Workers, Those Exposed to Metals, Volatile Compounds on Job

Those working in production occupations, especially those exposed to volatile organic compounds, metals, combustion pollutants, and particulate matter have a higher risk of developing ALS.

Featured Genetics Neurology Neuroscience

·June 22, 2022·4 min read

ALS May Be Linked to Both the Immune and Central Nervous Systems

Researchers discovered both immune system and central nervous system dysfunction in animal models and people with ALS4, a genetic, juvenile, and slow-progressing form of ALS.