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amyotrophic lateral sclerosis

Featured Neurology Neuroscience Open Neuroscience Articles

·March 18, 2022·5 min read

Could There Be a Link Between the Enteric Neurons, Gut Microbiome and ALS?

Study reveals an association between intestinal inflammation and the gut microbiome in the development and progression of ALS.

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Featured Neurology Neuroscience

·March 10, 2022·4 min read

Motor Neuron Toxin Associated With ALS Identified

PolyP, an inorganic polyphosphate released by astrocytes in people with ALS and frontotemporal dementia contributes to the signature motor neuron death associated with the disease pathologies.

Featured Genetics Neurology Neuroscience

·February 28, 2022·4 min read

A New Molecular Pathway Shared by Two Neurodegenerative Disorders Discovered

Mislocalization of the TDP-43 protein alters the genetic instructions for UNC13A. The findings provide a potential new therapeutic target for the treatment of ALS and frontotemporal dementia.

Featured Neurology Neuroscience Open Neuroscience Articles

·January 28, 2022·4 min read

Simple and Reliable ALS Diagnosis With Blood Tests

Measuring the level of neurofilaments in the blood may be a reliable biomarker for the early diagnosis of ALS.

Featured Genetics Neurology Neuroscience

·January 19, 2022·6 min read

Astrocyte Studies Reveal Harmful Changes in Amyotrophic Lateral Sclerosis

In patients with ALS, astrocytes within the brain become pro-inflammatory and tend to lose their protective function, resulting in changes in the ability to uptake glutamate.

Featured Neurology Neuroscience

·November 10, 2021·4 min read

New Insights on ALS May Point To a Potentially Promising Treatment Strategy

Post-mortem studies of brain tissue from ALS patients reveal an abnormal form of tau is present in novel brain areas, and the tau interacts with DRP1. The tau appears to cause the brain cell's mitochondria to fragment and increase oxidative stress. Reducing tau reversed the effect, decreasing oxidative stress and mitochondrial fragmentation.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·August 6, 2021·5 min read

Key Hallmark of ALS Reversed

Researchers reveal how proteins accumulate in the incorrect parts of brain cells in ALS, and demonstrate how it may be possible to reverse the accumulation.

Featured Genetics Neurology Neuroscience

·July 8, 2021·4 min read

ALS: Study Shows Role of Brain’s Immune Cells

Hyperactive microglia immune cells may play a significant role in the development of ALS, researchers report.

This shows a woman, a brain and a neuron

Featured Neurology Neuroscience

·February 23, 2021·5 min read

ALS Neuron Damage Reversed With New Compound

NU-9, a novel, non-toxic compound, targets upper motor neurons and reverses damage associated with ALS within 60 days of treatment.

Featured Genetics Neurology Neuroscience

·December 9, 2020·4 min read

New Biomarker Candidate for ALS

A novel method detected conformational changes to the TDP-43 protein in cerebral spinal fluid associated with ALS.

Featured Neurology Neuroscience Open Neuroscience Articles

·September 8, 2020·5 min read

Investigational Drug Stops Toxic Proteins Tied To ALS

c9ASO, an investigational ASO drug, targets the TDP-43 protein, reducing its buildup and decreasing neurological decline associated with ALS and FTD.

Featured Neurology Open Neuroscience Articles

·September 3, 2020·4 min read

Promising New ALS Drug Candidates

Ebselen, a Selenium-based drug molecule, and several other novel compounds can change the characteristics of SOD1. The findings could help with the development of new therapeutics for ALS.

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amyotrophic lateral sclerosis

Could There Be a Link Between the Enteric Neurons, Gut Microbiome and ALS?

Motor Neuron Toxin Associated With ALS Identified

A New Molecular Pathway Shared by Two Neurodegenerative Disorders Discovered

Simple and Reliable ALS Diagnosis With Blood Tests

Astrocyte Studies Reveal Harmful Changes in Amyotrophic Lateral Sclerosis

New Insights on ALS May Point To a Potentially Promising Treatment Strategy

Key Hallmark of ALS Reversed

ALS: Study Shows Role of Brain’s Immune Cells

ALS Neuron Damage Reversed With New Compound

New Biomarker Candidate for ALS

Investigational Drug Stops Toxic Proteins Tied To ALS

Promising New ALS Drug Candidates

Psychedelic Trips Can Halt Political Hate

LLMs and Math Combine to Map Human Decision-Making

Sleep Apnea’s Main Symptom Is Also its Cause

Zero-Computational Path to High-Resolution Robotic Touch

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