Brains Cells Born Together Wire and Fire Together for Life

Summary: Neurons that were “born” at the same time show distinct connectivity and activity throughout the life of an animal.

Source: NYU Langone

Brain cells with the same “birthdate” are more likely to wire together into cooperative signaling circuits that carry out many functions, including the storage of memories, a new study finds.

Led by researchers from NYU Grossman School of Medicine, the new study on the brains of mice developing in the womb found that brain cells (neurons) with the same birthdate showed distinct connectivity and activity throughout the animals’ adult lives, whether they were asleep or awake.

Published online August 22 in Nature Neuroscience, the findings suggest that evolution took advantage of the orderly birth of neurons—by gestational day—to form localized microcircuits in the hippocampus, the brain region that forms memories.

Rather than attempting to create each new memory from scratch, the researchers suggest, the brain may exploit the stepwise formation of neuronal layers to establish neural templates, like “Lego pieces,” that match each new experience to an existing template as it is remembered.

These rules of circuit assembly would suggest that cells born together are more likely to encode memories together, and to fail together, potentially implicating neuronal birthdate in diseases like autism and Alzheimer’s, say the authors. With changes to the number of cells born at different days, the developing brain may be more vulnerable on some gestational days to viral infections, toxins, or alcohol.

“Our study’s results suggest that which day a hippocampal neuron is born strongly influences both how that single cell performs, and how populations of such cells signal together throughout life,” says senior study author György Buzsáki, MD, Ph.D., the Biggs Professor in the Department of Neuroscience and Physiology at NYU Langone Health.

“This work may reshape how we study neurodevelopmental disorders, which have traditionally been looked at through a molecular or genetic, rather than a developmental, lens,” says Buzsáki, also a faculty member in the Neuroscience Institute at NYU Langone.”

New Understanding

The current study’s innovation rests on tracking the activity of neurons of a given birthdate into adulthood. To accomplish this, the researchers relied on a technique that allowed them to transfer DNA into cells that were undergoing division into neurons in the womb.

The DNA expressed markers that tagged brain cells that were born on same day, akin to a barcode. This labeling method then enabled the researchers to study these neurons in the adult animal.

Using a combination of techniques, the new study found that neurons of the same birthdate tend to “co-fire” together, characterized by synchronized swings in their positive and negative charges, allowing them to transmit electrical signals collectively. A likely reason for the co-firing, say the authors, is that neurons with the same birthdate are connected via shared neurons.

Past work had shown that activity in the hippocampus can be described in terms patterns of collective neuronal activity during waking and sleep.

This shows hippocampal neurons
Groups of brain cells that are born together on the same days (pink) and different days (blue) in the hippocampus of a mouse embryo. Many more neurons are born on embryonic day 15.5 than on earlier or later days. The study found that cells with the same birthdates during development form circuits that work together to encode similar memories. Credit: The Researchers

During sleep, for instance, when each day’s memories are consolidated for long-term memory storage, hippocampal neurons engage in a cyclical burst of activity called the “sharp wave-ripple,” named for the shape it takes when captured graphically by EEG, a technology that records brain activity with electrodes.

“Our results show that neurons born on the same day become part of the same cooperating assemblies, and participate in the same sharp wave-ripples and represent the same memories,” says first author Roman Huszár, a graduate student in Buzsáki’s lab.

“These relationships, and the pre-set templates they encode, have a key implication for hippocampal function: the storage of a memory about a place or event.”

Moving forward, the team plans additional experiments to identify the genes active in the same birthdate neurons in different brain regions, and to test their role in memory formation and behavior.

Along with Buzsáki and and Huszár, the other study authors were Yunchang Zhang from the NYU Neuroscience Institute and the Center for Neural Science at New York University; and Heike Blockus of the Department of Neuroscience and Zuckerman Mind Brain Behavior Institute at Columbia University.

About this neuroscience research news

Author: Press Office
Source: NYU Langone
Contact: Press Office – NYU Langone
Image: The image is credited to the researcher

Original Research: Closed access.
Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis” by Roman Huszár et al. Nature Neuroscience


Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis

The incorporation of new information into the hippocampal network is likely to be constrained by its innate architecture and internally generated activity patterns.

However, the origin, organization and consequences of such patterns remain poorly understood. In the present study we show that hippocampal network dynamics are affected by sequential neurogenesis.

We birthdated CA1 pyramidal neurons with in utero electroporation over 4 embryonic days, encompassing the peak of hippocampal neurogenesis, and compared their functional features in freely moving adult mice. Neurons of the same birthdate displayed distinct connectivity, coactivity across brain states and assembly dynamics.

Same-birthdate neurons exhibited overlapping spatial representations, which were maintained across different environments. Overall, the wiring and functional features of CA1 pyramidal neurons reflected a combination of birthdate and the rate of neurogenesis.

These observations demonstrate that sequential neurogenesis during embryonic development shapes the preconfigured forms of adult network dynamics.

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