Summary: A new study reveals that the Mediterranean diet may enhance cognitive function by altering gut microbiota. Rats fed a Mediterranean-style diet showed distinct bacterial changes linked to better memory, cognitive flexibility, and working memory compared to those on a Western diet.
Beneficial bacteria levels increased, while harmful ones decreased, improving performance on memory and learning tasks. These findings suggest that dietary patterns influence brain health through the gut, potentially benefiting young adults during critical developmental periods.
Key Facts:
- Gut-Brain Connection: The Mediterranean diet reshapes gut microbiota, improving cognitive function.
- Cognitive Gains: Better memory, flexibility, and working memory were linked to gut bacteria changes.
- Dietary Impact: Mediterranean components like olive oil, fish, and fiber boosted beneficial bacteria.
Source: Tulane University
A new Tulane University study suggests the Mediterranean diet’s brain-boosting benefits may work by changing the balance of bacteria in the gut.
In a study published in Gut Microbes Reports, researchers at Tulane University School of Medicine found that subjects following a Mediterranean diet developed distinctly different gut bacteria patterns compared to those eating a typical Western diet.
These bacterial changes correlated with better memory and cognitive performance.
“We’ve known that what we eat affects brain function, but this study explores how that could be happening,” said lead author Rebecca Solch-Ottaiano, PhD, neurology research instructor at Tulane’s Clinical Neuroscience Research Center.
“Our findings suggest that dietary choices can influence cognitive performance by reshaping the gut microbiome.”
The study found that rats fed a Mediterranean-style diet rich in olive oil, fish and fiber over 14 weeks showed increases in four beneficial types of gut bacteria and decreases in five others compared to rats eating a Western diet high in saturated fats.
These bacterial changes were linked to improved performance on maze challenges designed to test memory and learning.
Specifically, higher levels of bacteria such as Candidatus Saccharimonas were associated with better cognitive performance, while increased levels of other bacteria, such as Bifidobacterium, correlated with poorer memory function.
The Mediterranean diet group also showed better cognitive flexibility — the ability to adapt to new information — and improved working memory compared to the Western diet group. They maintained lower levels of “bad” LDL cholesterol.
This study is the first to assess the effects of the Mediterranean on microbiota and cognitive function outcomes relative to the Western diet in a rodent model. The researchers used young rats approximately equivalent in age to 18-year-old humans to model the effects of diet during a critical developmental period.
The diets were based on human consumption and used ingredients reflecting the complexity of human diets. The Mediterranean diet (MeDi) showed clear benefits for cognitive flexibility, memory, and gut health, suggesting potential parallels in young adults whose brains and bodies are still maturing.
“Our findings suggest that the Mediterranean diet or its biological effects could be harnessed to improve scholastic performance in adolescents, or work performance in young adults,” said corresponding author Dr. Demetrius M. Maraganore, Herbert J. Harvey, Jr. Chair of Neurosciences.
“While these findings are based on animal models, they echo human studies linking the Mediterranean diet to improved memory and reduced dementia risk.”
The researchers emphasize that larger human studies are needed to confirm these effects and better understand the complex relationship between diet, gut bacteria, and brain function in young people.
For those interested in following a Mediterranean eating pattern, key components include:
– Olive oil as the primary fat source
– Abundant vegetables, fruits and whole grains
– Fish and lean proteins
– Limited red meat and saturated fats
– High fiber intake from various plant sources
Other Tulane co-authors of the study include Elizabeth B. Engler-Chiurazzi, Colin Harper, Savannah Wasson, Sharon Ogbonna, Blake Ouvrier, Hanyun Wang, Madison Prats, Katherine McDonald, Ifechukwude J. Biose, Lori A. Rowe, MaryJane Jones, Chad Steele and Gregory Bix.
About this diet and cognition research news
Author: Keith Brannon
Source: Tulane University
Contact: Keith Brannon – Tulane University
Image: The image is credited to Neuroscience News
Original Research: Open access.
“Comparison between two divergent diets, Mediterranean and Western, on gut microbiota and cognitive function in young sprague dawley rats” by Rebecca Solch-Ottaiano et al. Gut Microbes Reports
Abstract
Comparison between two divergent diets, Mediterranean and Western, on gut microbiota and cognitive function in young sprague dawley rats
Clinical studies strongly suggest the importance of diet quality on cognition in youth populations (15–24 years).
The Mediterranean diet (MeDi) has been shown to improve cognition in contrast to the commonly consumed Western diet (WD). The gut microbiota may serve as a mechanism for diet-induced changes in cognition.
Ten-week-old male Sprague Dawley rats were assigned a MeDi or WD (n = 10/group) for 14 weeks. Prior to neurobehavior assessments, microbiota community composition was assessed.
At the genus level, the relative abundance of four bacteria increased with the MeDi and five decreased compared to the WD. Rats in the MeDi group demonstrated cognitive flexibility and improvement in reference and working memory relative to the WD group.
At the end of the study, serum cytokines were increased, and low-density lipoproteins were decreased in the MeDi group. Markers for neuroinflammation, blood-brain barrier, glial cells, and synaptic plasticity in brain regions did not differ between groups.
Overall, the MeDi modulated gut microbiota, cognitive function, and serum lipid and cytokines but not gene expression in the brain compared to the WD.
Further studies are needed to determine causality between diet-modulated gut microbiota, cognitive function, and immune function.
