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Summary: Study reveals how a pregnant woman’s vaccine-induced immunities are transferred to her offspring via the placenta. The findings have positive implications for the development of new, more effective maternal vaccines.
Source: Mass General
One of the most successful interventions in reducing infectious disease worldwide, vaccination still has limited effectiveness in protecting one group of patients – newborn infants. Now a study based at the Ragon Institute of MGH, MIT and Harvard has determined how a pregnant woman’s vaccine-induced immunity is transferred to her child, which has implications for the development of more effective maternal vaccines. The report will be published in the June 27 issue of Cell and is receiving early online release.
“Newborns arrive into the world on the first day of life with brand-new immune systems that, like the children themselves, need to learn to cope with both helpful and harmful microbes in their environment,” says Galit Alter, PhD, of the Ragon Institute and the Massachusetts General Hospital (MGH) Department of Medicine, co-senior author of the Cell paper. “To help the newborn immune system learn to discriminate between friend and foe, mothers transfer antibodies to their infants via the placenta. The rules by which the placenta performs this absolutely essential function have been unknown but, if decoded, could hold the key to generating more powerful vaccines to protect these most precious patients.”
While maternal antibodies against some diseases such as measles can be transferred from mother to infant, providing some protection until the child is old enough for individual vaccination, antibodies to other serious diseases like polio are less efficiently transferred. To investigate the mechanisms by which antibodies are transferred from mother to child, Alter and her team – including co-senior author Laura Riley, MD, formerly with the MGH Department of Obstetrics and Gynecology and now the chair of Obstetrics and Gynecology at Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center – used a novel tool called system serology to compare the quantity and quality of antibodies against pertussis in blood samples from mothers and from the umbilical cords that carry blood, nutrients and immune factors from the placenta to the infant.
Their investigation revealed that the placenta preferentially sifts out and delivers to the infant antibodies that activate natural killer (NK) cells, key elements of the innate immune system. While several important immune cells are too immature in newborns to provide effective protection, NK cells are among the most abundant and functional immune cells during the first days of life. The team found a similar preference for placental transfer of NK-activating antibodies against influenza and respiratory syncytial virus, a common disease of childhood, and also identified antibody features that appear to regulate placental selection, features that could possibly be built into next-generation vaccines with improved mother-to-child antibody transfer.
Co-senior author Riley says, “We will now have the opportunity to create better maternal vaccines and deliver them at the ideal time during pregnancy to maximally protect newborns when they are most vulnerable.” Riley and Alter will be actively investigating additional aspects of maternal: infant immunity to pave the way for developing improved maternal vaccines.
Alter is a professor of Medicine at Harvard Medical School, and Riley is the Given Foundation Professor of Obstetrics and Gynecology at Weill Cornell Medicine. The lead author of the Cell paper is Madeleine Jennewein of the Ragon Institute.
Funding: Support for the study includes National Institutes of Health grants 5R37 AI080289-09, 5R01 AI102660-04 and 1R01 AI129797-01 and the Samana Cay MGH Research Scholar award to Alter.
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Source: Mass General Noah Brown – Mass General Image Source: The image is in the public domain.
Original Research: Closed access “Fc Glycan-Mediated Regulation of Placental Antibody Transfer”. Laura Riley et al. Cell. doi:10.1016/j.cell.2019.05.044
Fc Glycan-Mediated Regulation of Placental Antibody Transfer
Highlights • NK cell-activating antibodies are selectively transferred across the placenta • Digalactosylated Fc glycans are preferentially transferred across the placenta • Digalactosylated antibodies bind more effectively to FcRn and FCGR3A • Although immature, neonatal NK cells are highly responsive to immune complexes
Summary Despite the worldwide success of vaccination, newborns remain vulnerable to infections. While neonatal vaccination has been hampered by maternal antibody-mediated dampening of immune responses, enhanced regulatory and tolerogenic mechanisms, and immune system immaturity, maternal pre-natal immunization aims to boost neonatal immunity via antibody transfer to the fetus. However, emerging data suggest that antibodies are not transferred equally across the placenta. To understand this, we used systems serology to define Fc features associated with antibody transfer. The Fc-profile of neonatal and maternal antibodies differed, skewed toward natural killer (NK) cell-activating antibodies. This selective transfer was linked to digalactosylated Fc-glycans that selectively bind FcRn and FCGR3A, resulting in transfer of antibodies able to efficiently leverage innate immune cells present at birth. Given emerging data that vaccination may direct antibody glycosylation, our study provides insights for the development of next-generation maternal vaccines designed to elicit antibodies that will most effectively aid neonates.
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