Study Links Diet, Diabetes, and Alzheimer’s

Summary: A new study explores the molecular connections between Type 2 diabetes and Alzheimer’s, supporting the notion of Alzheimer’s as “Type 3 diabetes.”

This study finds that a high-fat diet suppresses a crucial gut protein, Jak3, leading to Alzheimer’s-like brain changes in mice. It underscores the importance of managing diabetes or avoiding it through diet to reduce Alzheimer’s risk.

The findings illuminate a potential path from diet through gut inflammation to brain health, offering hope for preventative strategies.

Key Facts:

  1. Molecular Connection: The suppression of the Jak3 protein in the gut due to a high-fat diet can initiate a cascade of inflammation leading to Alzheimer’s-like symptoms in the brain.
  2. Preventative Potential: Controlling or avoiding diabetes through diet and blood sugar management could significantly reduce the risk of developing Alzheimer’s disease.
  3. Broad Implications: Given the vast number of U.S. adults with prediabetes, lifestyle changes to prevent diabetes may also mitigate Alzheimer’s risk, highlighting the critical intersection of diet, metabolic health, and neurodegeneration.

Source: ASBMB

New research conducted in mice offers insights into what’s going on at the molecular level that could cause people with diabetes to develop Alzheimer’s disease.

The study adds to a growing body of research on the links between Type 2 diabetes and Alzheimer’s disease, which some scientists have called “Type 3 diabetes.”

The findings suggest that it should be possible to reduce the risk of Alzheimer’s by keeping diabetes well controlled or avoiding it in the first place, according to researchers.

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To find out how diet could influence the development of Alzheimer’s in people with diabetes, the researchers traced how a particular protein in the gut influences the brain. Credit: Neuroscience News

Narendra Kumar, an associate professor at Texas A&M University in College Station, led the study.

“We think that diabetes and Alzheimer’s disease are strongly linked,” Kumar said, “and by taking preventative or amelioration measures for diabetes, we can prevent or at least significantly slow down the progression of the symptoms of dementia in Alzheimer’s disease.”

Kumar will present the new research at Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, which is being held March 23–26 in San Antonio.

Diabetes and Alzheimer’s are two of the fastest-growing health concerns worldwide. Diabetes alters the body’s ability to turn food into energy and affects an estimated 1 in 10 U.S. adults. Alzheimer’s, a form of dementia that causes progressive decline in memory and thinking skills, is among the top 10 leading causes of death in the United States.

Diet is known to influence the development of diabetes as well as the severity of its health impacts. To find out how diet could influence the development of Alzheimer’s in people with diabetes, the researchers traced how a particular protein in the gut influences the brain.

They found that a high-fat diet suppresses the expression of the protein, called Jak3, and that mice without this protein experienced a cascade of inflammation starting with the intestine, moving through the liver and on to the brain.

Ultimately, the mice showed signs of Alzheimer’s-like symptoms in the brain, including an overexpressed mouse beta-amyloid and hyperphosphorylated tau, as well as evidence of cognitive impairment.

“Liver being the metabolizer for everything we eat, we think that the path from gut to the brain goes through liver,” Kumar said.

His lab has been studying functions of Jak3 for a long time, he added, and they now know that the impact of food on the changes in the expression of Jak3 leads to leaky gut. This in turn results in low-grade chronic inflammation, diabetes, decreased ability of the brain to clear its toxic substances and dementia-like symptoms seen in Alzheimer’s disease.

The good news, according to Kumar, is that it may be possible to stop this inflammatory pathway by eating a healthy diet and getting blood sugar under control as early as possible.

In particular, people with prediabetes — which includes an estimated 98 million U.S. adults — could benefit from adopting lifestyle changes to reverse prediabetes, prevent the progression to Type 2 diabetes and potentially reduce the risk of Alzheimer’s.

About this diabetes, dementia, and diet research news

Author: Anne Johnson
Source: ASBMB
Contact: Anne Johnson – ASBMB
Image: The image is credited to Neuroscience News

Original Research: The findings will be presented at Discover BMB

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  1. Blood sugar, gut permeability, mitochrondrial function, and a high fat diet have a complicated inter-relationship. When lipids replace glucose for energy production, as in ketosis, blood sugar is improved and insulin resistance may be reduced. There is current research supporting high fat / low carb diets in promoting brain health and reducing DMII risk, which this study seems to contradict. The JAK-3 protein may one piece of a much larger puzzle.

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