Dipeptidyl peptidase-4 inhibitors, a class of drug that reduces blood sugar in type 2 diabetes, were associated with less amyloid accumulation in the brain and slower cognitive decline in patients.
Obese mice treated with the TSLP cytokine showed a significant loss in abdominal fat and weight. The fat loss was not associated with reduced food intake or faster metabolism, instead the cytokine stimulated the immune system to release lipids via the skin's oil-producing sebaceous glands.
Sleep disruptions have been linked to a higher risk of death, especially in those with type 2 diabetes. Researchers found those with type 2 diabetes who reported frequent sleep disruptions, were 87% more likely to die of any cause than those without diabetes or sleep disturbances. Additionally, those with diabetes and sleep disruptions were 12% more die over a nine-year period than those with diabetes alone.
Type 2 diabetes is not only associated with an increased risk of developing Parkinson's disease, but it's also associated with an accelerated progression of Parkinson's symptoms.
Metformin, a drug commonly used to treat diabetes, slows cognitive decline and reduces dementia risk in older people with diabetes.
Older women with type 2 diabetes do not use as much oxygenated blood in their brains as those who do not have the disease. Findings demonstrate alterations in neural blood use are a primary reason for deficits in motor function experienced by those with diabetes.
Researchers demonstrate how a single injection of fibroblast growth factor 1 (FGF1) can restore blood sugar levels to normal for extended periods in rodent models of type 2 diabetes. Studies show how FGF1 affects specific neurons and perineuronal nets to help restore blood sugar levels to normal, thus sending diabetes into remission.
Summary: In males, a genetic variant of DUSP8 can increase the risk of type 2 diabetes by impairing the brain’s...
It is well reported that diabetes is a risk factor for severe COVID-19 infections and increased mortality risk as a result of the virus. A new study reports those with Type 2 diabetes with well-controlled blood sugar levels fare much better if the contract coronavirus than those with poorly controlled blood glucose levels.
The risk of severe complications, including death, from coronavirus, is almost 50% higher in those with diabetes than the general population. Although it is yet to be verified in humans, new findings suggest diabetes may not only be a risk factor for severe COVID-19, but the infection could result in causing new onset of diabetes due to the damage it causes to pancreatic beta cells.
Previous studies of related coronaviruses SARS and MERS found blocking DPP4 activity reduced inflammatory response. Researchers suggest drugs that target DPP4 could help to reduce the overexpression of inflammatory cytokines seen in severe COVID-19.
Consumed alone, artificial sweeteners do not appear to have a negative impact. However, when consumed with carbohydrates, insulin sensitivity changes and the brain has a decreased response to sweet tastes.