As plaque deposits increase in the aging brain, money management falters

Summary: Older adults who experience problems completing simple financial tasks, such as calculating their change, may be at increased risk of Alzheimer’s disease. Problems with financial management have often been associated with later stage dementia. A new study reveals this could be one of the earliest signs of dementia and may be correlated with a build-up of amyloid plaque deposits.

Source: Duke University Medical Center

Aging adults often show signs of slowing when it comes to managing their finances, such as calculating their change when paying cash or balancing an account ledger.

These changes happen even in adults who are cognitively healthy. But trouble managing money can also be a harbinger of dementia and, according to new Duke research in The Journal of Prevention of Alzheimer’s Disease, could be correlated to the amount of protein deposits built up in the brain.

“There has been a misperception that financial difficulty may occur only in the late stages of dementia, but this can happen early and the changes can be subtle,” said P. Murali Doraiswamy, MBBS, a professor of psychiatry and geriatrics at Duke and senior author of the paper. “The more we can understand adults’ financial decision-making capacity and how that may change with aging, the better we can inform society about those issues.”

The findings are based on 243 adults ages 55 to 90 participating in a longitudinal study called the Alzheimer’s Disease Neuroimaging Initiative, which included tests of financial skills and brain scans to reveal protein buildup of beta-amyloid plaques.

The study included cognitively healthy adults, adults with mild memory impairment (sometimes an Alzheimer’s precursor) and adults with an Alzheimer’s diagnosis.

Testing revealed that specific financial skills declined with age and at the earliest stages of mild memory impairment. The decline was similar in men and women. After controlling for a person’s education and other demographics, the scientists found the more extensive the amyloid plaques were, the worse that person’s ability to understand and apply basic financial concepts or completing tasks such as calculating an account balance.

“Older adults hold a disproportionate share of wealth in most countries and an estimated $18 trillion in the U.S. alone,” Doraiswamy said. “Little is known about which brain circuits underlie the loss of financial skills in dementia. Given the rise in dementia cases over the coming decades and their vulnerability to financial scams, this is an area of high priority for research.”

Even cognitively healthy people can develop protein plaques as they age, but the plaques may appear years earlier and be more widespread in those at risk for Alzheimer’s disease due to a family history or mild memory impairment, Doraiswamy said.

Most testing for early dementia and Alzheimer’s disease focuses on memory, said Duke researcher Sierra Tolbert, the study’s lead author. A financial capacity assessment, such as the 20-minute Financial Capacity Instrument-Short Form used in the Duke study, could also be a tool for doctors to track a person’s cognitive function over time and is sensitive enough to detect even subtle changes, she said.

This shows brain scans

Scans of two study participants show the brain of a cognitively healthy 74-year-old (top row) who demonstrated average financial skills compared to an 86-year-old with mild Alzheimer’s disease (bottom row) who demonstrated impaired financial skills. The bottom scan is positive for amyloid plaques, highlighted in yellow and orange throughout the brain and extending to its edges. The image is credited to Duke Health.

“Doctors could consider proactively counseling their patients using this scale, but it’s not widely in use,” Tolbert said. “If someone’s scores are declining, that could be a warning sign. We’re hoping with this research more doctors will become aware there are tools that can measure subtle changes over time and possibly help patients and families protect their loved ones and their finances.”

In addition to Doraiswamy and Tolbert, study authors include Yuhan Liu, Caroline Hellegers, Jeffrey R. Petrella, Michael W. Weiner and Terence Z. Wong.

This research used data from the Alzheimer’s Disease Neuroimaging Initiative, which is funded by the National Institutes of Health (U01 AG024904) and the U.S. Department of Defense (W81XWH-12-2-0012), as well as the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through contributions from numerous other organizations. A full list of contributors and financial disclosures is available with the manuscript.

About this neuroscience research article

Source:
Duke University Medical Center
Media Contacts:
Samiha Khanna – Duke University Medical Center
Image Source:
The image is credited to Duke Health.

Original Research: Closed access
“FINANCIAL MANAGEMENT SKILLS IN AGING, MCI AND DEMENTIA: CROSS SECTIONAL RELATIONSHIP TO 18F-FLORBETAPIR PET CORTICAL Β-AMYLOID DEPOSITION”. S. Tolbert, Y. Liu, C. Hellegers, J.R. Petrella, M.W. Weiner, T.Z. Wong, P. Murali Doraiswamy, for the ADNI Study Group.
The Journal of Prevention of Alzheimer’s Disease. doi:10.14283/jpad.2019.26

Abstract

FINANCIAL MANAGEMENT SKILLS IN AGING, MCI AND DEMENTIA: CROSS SECTIONAL RELATIONSHIP TO 18F-FLORBETAPIR PET CORTICAL Β-AMYLOID DEPOSITION

Background: There is a need to more fully characterize financial capacity losses in the preclinical and prodromal stages of Alzheimer’s disease (AD) and their pathological substrates. Objectives: To test the association between financial skills and cortical β-amyloid deposition in aging and subjects at risk for AD.

Design: Cross-sectional analyses of data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI-3) study conducted across 50 plus sites in the US and Canada. Setting: Multicenter biomarker study. Participants: 243 subjects (144 cognitively normal, 79 mild cognitive impairment [MCI], 20 mild AD).

Measurements: 18F-Florbetapir brain PET scans to measure global cortical β-amyloid deposition (SUVr) and the Financial Capacity Instrument Short Form (FCI-SF) to evaluate an individual’s financial skills in monetary calculation, financial concepts, checkbook/register usage, and bank statement usage. There are five sub scores and a total score (range of 0–74) with higher scores indicating better financial skill.

Results: FCI-SF total score was significantly worse in MCI [Cohen’s d= 0.9 (95%CI: 0.6-1.2)] and AD subjects [Cohen’s d=3.1(CI: 2.5-3.7)] compared to normals. Domain scores and completion times also showed significant difference. Across all subjects, higher cortical β-amyloid SUVr was significantly associated with worse FCI-SF total score after co-varying for age, education, and cognitive score [Cohen’s f2=0.751(CI: 0.5-1.1)]. In cognitively normal subjects, after covarying for age, gender, and education, higher β -amyloid PET SUVr was associated with longer task completion time [Cohen’s f2=0.198(CI: 0.06-0.37)].

Conclusion: Using a multicenter study sample, we document that financial capacity is impaired in the prodromal and mild stages of AD and that such impairments are, in part, associated with the extent of cortical β-amyloid deposition. In normal aging, β-amyloid deposition is associated with slowing of financial tasks. These data confirm and extend prior research highlighting the utility of financial capacity assessments in at risk samples.

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