Summary: A 12-year-long study found a significant rise in exposure to chemicals from plastics and pesticides in pregnant women which may be harmful to development. Many of the chemicals were “replacement chemicals”, ones designed to replace banned chemicals, which may be just as harmful as the ones they replaced.
A national study that enrolled a highly diverse group of pregnant women over 12 years found rising exposure to chemicals from plastics and pesticides that may be harmful to development.
Many of the chemicals that the women had been exposed to were replacement chemicals: new forms of chemicals that have been banned or phased out that may be just as harmful as the ones they replaced. The study also found many women had been exposed to neonicotinoids, a kind of pesticide that is toxic to bees.
Researchers measured 103 chemicals, mostly from pesticides, plastics, and replacement chemicals for BPA and phthalates, using a new method that captured dozens of chemicals or chemical traces from a single urine sample.
More than 80 percent of the chemicals were found in at least one of the women in the study, and more than a third of the chemicals were found in a majority of the participants. The study also found that some of these chemicals were present in higher amounts than seen in earlier studies.
“This is the first time we’ve been able to measure the amounts of chemicals in such a large and diverse group of pregnant women – not just identify chemicals,” said Tracey J. Woodruff, PhD, professor and director of the University of California, San Francisco (UCSF) Program on Reproductive Health and the Environment and co-director of the UCSF EaRTH Center, and the senior author of the study, appearing online May 10, 2022, in Environmental Science & Technology.
“Our findings make clear that the number and scope of chemicals in pregnant women are increasing during a very vulnerable time of development for both the pregnant person and the fetus.”
Prenatal exposure to industrial chemicals can come from air, food, water, plastics, and other industrial and consumer products. Although these chemicals could be harmful to pregnancy and child development, few of these chemicals are routinely monitored in people.
The study included 171 women from California, Georgia, Illinois, New Hampshire, New York, and Puerto Rico who are part of the National Institutes of Health Environmental influences on Child Health Outcomes program. About one-third (34%) were white, 40% were Latina, 20% were Black, and the remaining 6% were from other or multiple groups.
The study found higher exposures for non-white women, those with lower educational attainment, or who were single or had been exposed to tobacco. But Latinas had especially high levels of parabens, which are used as preservatives, as well as phthalates and bisphenols, which are used in plastics.
“While pesticides and replacement chemicals were prevalent in all women, we were surprised to find that Latinas had substantially higher levels of parabens, phthalates and bisphenols,” said Jessie Buckley, PhD, associate professor of environmental health and engineering, as well as of epidemiology, at Johns Hopkins Bloomberg School of Public Health and first author of the study.
“This could be the result of higher exposures to products with chemicals, such as processed foods or personal care products,” Buckley said.
Authors: The full list of authors is available in the paper.
Funding: Research reported in this publication was supported by the Environmental influences on Child Health Outcomes (ECHO) program, Office of The Director, National Institutes of Health, under Award Numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (PRO Core), U2CES026542 (HHEAR), and UH3OD023251, UH3OD023272, UH3OD023275, UH3OD023287, UH3OD023290, UH3OD023318, UH3OD023342, UH3OD023349, UH3OD023347, UH3OD023365 (cohort grantees).
About this environmental neuroscience research news
Author: Laura Kurtzman
Contact: Laura Kurtzman – UCSF
Image: The image is in the public domain
Original Research: Open access.
“Exposure to Contemporary and Emerging Chemicals in Commerce among Pregnant Women in the United States: The Environmental influences on Child Health Outcome (ECHO) Program” by Tracey J. Woodruff, et al. Environmental Science & Technology
Exposure to Contemporary and Emerging Chemicals in Commerce among Pregnant Women in the United States: The Environmental influences on Child Health Outcome (ECHO) Program
Prenatal chemical exposures can influence maternal and child health; however, few industrial chemicals are routinely biomonitored.
We assessed an extensive panel of contemporary and emerging chemicals in 171 pregnant women across the United States (U.S.) and Puerto Rico in the Environmental influences on Child Health Outcomes (ECHO) Program.
We simultaneously measured urinary concentrations of 89 analytes (103 total chemicals representing 73 parent compounds) in nine chemical groups: bactericides, benzophenones, bisphenols, fungicides and herbicides, insecticides, organophosphate esters (OPEs), parabens, phthalates/alternative plasticizers, and polycyclic aromatic hydrocarbons (PAHs).
We estimated associations of creatinine-adjusted concentrations with sociodemographic and specimen characteristics. Among our diverse prenatal population (60% non-Hispanic Black or Hispanic), we detected 73 of 89 analytes in ≥1 participant and 36 in >50% of participants.
Five analytes not currently included in the U.S. biomonitoring were detected in ≥90% of samples: benzophenone-1, thiamethoxam, mono-2-(propyl-6-carboxy-hexyl) phthalate, monocarboxy isooctyl phthalate, and monohydroxy-iso-decyl phthalate.
Many analyte concentrations were higher among women of Hispanic ethnicity compared to those of non-Hispanic White women. Concentrations of certain chemicals decreased with the calendar year, whereas concentrations of their replacements increased.
Our largest study to date identified widespread exposures to prevalent and understudied chemicals in a diverse sample of pregnant women in the U.S.