BPA Exposure of the Placenta Could Affect Fetal Brain Development

Summary: Direct transmission of BPA from a pregnant woman to her child via the placenta may have a negative impact on fetal brain development, researchers report.

Source: University of Missouri Columbia

In a new study, scientists at the University of Missouri demonstrate the direct transmission of bisphenol A (BPA) from a mother to her developing child via the placenta could negatively impact fetal brain development. Cheryl Rosenfeld, a professor of biomedical sciences in the College of Veterinary Medicine, and colleagues propose more attention should be placed on how this temporary organ affects fetal brain development.

“The placenta is only a temporary organ that aids in the exchange of nutrients and waste between mother and child during pregnancy, but how the placenta responds to toxicants like BPA during pregnancy can lead to long-term health consequences,” Rosenfeld said.

“We focused on the role of microRNAs within the placenta, which are known to be key mediators in regulating cellular functions, including neural development, and the identification of certain markers for cancer.”

Rosenfeld suspects the microRNAs are playing a role in how the effects of BPA exposure can lead to neurological disorders later in life.

“These microRNAs can be packaged inside extracellular vesicles and can be transported to distant organs within the body,” Rosenfeld said.

“We’re assuming that by changing the pattern of microRNAs in the placenta, these small molecules can then reach the brain, resulting in harmful effects. Even before the brain’s neurons are developed, these microRNA packages may already be guiding fetal brain development. These changes may even be different in female versus male fetuses.”

BPA is used in many household items such as plastic water bottles and food containers, and the epoxy coating of metal food cans. Exposure can occur during the simple act of microwaving food inside polycarbonate plastic food containers.

While recent efforts have begun toward making products “BPA free,” the more than decade-long debate surrounding what’s considered safe levels of BPA exposure continues. Numerous studies have looked into possible related health consequences, including neurobehavioral disorders, diabetes, obesity and various reproductive deficiencies.

Rosenfeld believes microRNAs’ changes in the placenta could also be used as an early diagnostic biomarker for BPA exposure.

“By identifying the relationship between these microRNAs and fetal brain development through BPA exposure, targeted therapies could eventually be developed to help prevent or reverse some of the harmful effects of BPA exposure that occur due to these microRNAs,” Rosenfeld said.

This shows a pregnant woman's belly
Rosenfeld suspects the microRNAs are playing a role in how the effects of BPA exposure can lead to neurological disorders later in life. Image is in the public domain

Future plans for this work include examining the relationship between the placenta and the brain outside of the body through using cell culture systems.

This latest discovery continues a more than decade-long interest by Rosenfeld on the effects of BPA exposure. Her most recent focus on the relationship between the placenta and the brain could help scientists with developing a foundation for an early step in translational medicine, or research that aims to improve human health by determining the relevance of animal science discoveries to people.

Funding: Funding was provided by a grant from the National Institute of Environmental Health Sciences (1R01ES025547). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agency.

About this brain development research news

Author: Eric Stann
Source: University of Missouri Columbia
Contact: Eric Stann – University of Missouri Columbia
Image: The image is in the public domain

Original Research: Closed access.
miRNA changes in the mouse placenta due to bisphenol A exposure” by Jiude Mao, Jessica A Kinkade, Nathan J Bivens & Cheryl S Rosenfeld. Epigenomics


miRNA changes in the mouse placenta due to bisphenol A exposure

Aim: To determine small RNA expression changes in mouse placenta induced by bisphenol A (BPA) exposure. 

Methods: Exposing female mice to BPA two weeks prior to conception through gestational day 12.5; whereupon fetal placentas were collected, frozen in liquid nitrogen and stored at -80°C. Small RNAs were isolated and used for small RNA-sequencing. 

Results: 43 small RNAs were differentially expressed. Target mRNAs were closely aligned to those expressed by thymus and brain, and pathway enrichment analyses indicated that such target mRNAs regulate neurogenesis and associated neurodevelopment processes. 

Conclusions: BPA induces several small RNAs in mouse placenta that might provide biomarkers for BPA exposure. Further, the placenta might affect fetal brain development through the secretion of miRNAs.

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