Summary: Reducing levels of the Alzheimer’s related Tau protein prevents autism-like behaviors in mouse models. Tau reduction also prevented seizures in the animals. Source: Gladstone Institute Autism manifests in myriad forms. Symptoms and severity vary from person to person, but all autism spectrum disorders share three core symptoms: impaired social interactions, communication deficits, and excessive repetitive behaviors. No existing medications can adequately treat the core symptoms, and new treatments are urgently needed. Now, researchers at the Gladstone Institutes report in Neuron that reducing levels of a protein called tau prevents the core symptoms from arising in mouse models simulating different forms of autism spectrum disorders. Tau reduction in these mice also prevented seizures, which occur in 30 percent of people with autism. “Our findings suggest that tau reduction holds promise as a potential treatment for some forms of autism,” said Lennart Mucke, MD, the founding director of the Gladstone Institute of Neurological Disease and senior author of the new paper. Tau has never before been linked to autism, but it is known for its role in Alzheimer’s disease and other neurodegenerative conditions. “We’ve uncovered an unexpected new connection between degenerative diseases of aging and developmental disorders of childhood,” said Mucke, who is also a professor of neurology and neuroscience at the University of California, San Francisco. Making the Leap from Alzheimer’s to Autism These surprising findings stem from an investigation of links between Alzheimer’s disease and epilepsy. Originally, Mucke and colleagues showed that tau reduction prevents epileptic activity and cognitive deficits in mouse models of Alzheimer’s disease and of Dravet syndrome, a severe childhood epilepsy. These findings intrigued Chao Tai, PhD, a scientist on Mucke’s team and first author of the new paper, who had previously studied Dravet syndrome at the University of Washington. “We wondered whether tau reduction could also prevent the signs of autism that are often seen in people with Dravet syndrome,” Tai said. To explore this possibility, the team investigated a mouse model of Dravet syndrome after deleting one or both copies of the gene that encodes tau. They found that reducing tau indeed prevented the development of core autism symptoms in this model. Even 50 percent reduction of tau showed major benefits. Because the causes of autism are so diverse, the researchers next tested the effect of tau reduction in a second mouse model of autism that results from a very different genetic mutation. Sure enough, “it also worked beautifully,” Tai said. “The autism-like behaviors were again strongly suppressed by tau reduction.” Tau reduction also prevented epilepsy, as well as two additional abnormalities seen in people with autism and related mouse models: an enlargement of the brain known as megalencephaly, and over-activation of the PI3K-Akt-mTOR signaling pathway, which regulates many important cell functions. Finally, the researchers investigated the molecular mechanisms by which tau reduction prevents these abnormalities. They found that tau reduction enhances the activity of a powerful enzyme called PTEN, which can prevent overactivation of the autism-promoting signaling pathway. Addressing a Dire Need for Novel Treatments The new findings highlight the potential of tau reduction to counteract both neurologic and psychiatric disorders. “Tau reduction appears to be the first strategy that can prevent both autism and epilepsy, two challenging conditions that all too often afflict the same people,” Mucke said. Tau has never before been linked to autism, but it is known for its role in Alzheimer’s disease and other neurodegenerative conditions. The image is in the public domain. “Autism is very frequent, affecting roughly one in 60 children,” Tai said. “Our findings could help address the urgent need for the development of better therapeutic strategies.” However, as the paper also demonstrates, tau reduction will probably not be effective against all forms of autism, and more research would be needed to determine exactly who might benefit. In addition, the alterations that cause autism likely affect the brain during early stages of development and well before the diagnosis is typically made. “We are therefore eager to investigate whether tau reduction can also reverse symptoms of autism after they have emerged,” Mucke said. “Ongoing studies in experimental models should help clarify optimal times for administering tau-lowering drugs to prevent or treat symptoms.”See alsoFeaturedNeurosciencePsychology·February 24, 2020Stress may drive people to give as well as receive emotional support Mucke and colleagues are developing and testing small-molecule drugs that could lower tau levels or increase the activity of PTEN. Other investigational tau-lowering approaches are already being tested in people as a potential treatment for Alzheimer’s disease, and this new research suggests that findings from those trials may also be informative in regard to autism. Funding: The National Institutes of Health and the Tau Consortium provided funding for this research. Other authors include Che-Wei Chang, Gui-Qiu Yu, Isabel Lopez, Xinxing Yu, Xin Wang, and Weikun Guo from the Gladstone Institutes. [divider]About this neuroscience research article[/divider] Source: Gladstone Institute Media Contacts: Megan McDevitt – Gladstone Institute Image Source: The image is in the public domain. Original Research: Closed access “Tau Reduction Prevents Key Features of Autism in Mouse Models”. Chao Tai, Che-Wei Chang, Gui-Qiu Yu, Isabel Lopez, Xinxing Yu, Xin Wang, Weikun Guo, Lennart Mucke. Neuron doi:10.1016/j.neuron.2020.01.038. Abstract Tau Reduction Prevents Key Features of Autism in Mouse Models Highlights • Tau reduction prevents autism-like behaviors in Scn1a RX/+ and Cntnap2 −/− mice • Tau reduction also prevents PI3K overactivation and megalencephaly in these models • Tau interacts with PTEN via its proline-rich domain and suppresses PTEN activity • PTEN is a critical mediator of the beneficial effects of tau reduction Summary Autism is characterized by repetitive behaviors, impaired social interactions, and communication deficits. It is a prevalent neurodevelopmental disorder, and available treatments offer little benefit. Here, we show that genetically reducing the protein tau prevents behavioral signs of autism in two mouse models simulating distinct causes of this condition. Similar to a proportion of people with autism, both models have epilepsy, abnormally enlarged brains, and overactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt (protein kinase B)/ mammalian target of rapamycin (mTOR) signaling pathway. All of these abnormalities were prevented or markedly diminished by partial or complete genetic removal of tau. We identify disinhibition of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a negative PI3K regulator that tau controls, as a plausible mechanism and demonstrate that tau interacts with PTEN via tau’s proline-rich domain. Our findings suggest an enabling role of tau in the pathogenesis of autism and identify tau reduction as a potential therapeutic strategy for some of the disorders that cause this condition. 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