Summary: Researchers report the sniff test may be used to diagnose mild cognitive impairment.
Source: University of Pennsylvania School of Medicine.
Adds to evidence that decline in sense of smell occurs alongside cognitive decline.
Tests that measure the sense of smell may soon become common in neurologists’ offices. Scientists have been finding increasing evidence that the sense of smell declines sharply in the early stages of Alzheimer’s, and now a new study from the Perelman School of Medicine at the University of Pennsylvania published today in the Journal of Alzheimer’s Disease confirms that administering a simple “sniff test” can enhance the accuracy of diagnosing this dreaded disease.
The sniff test also appears to be useful for diagnosing a pre-dementia condition called mild cognitive impairment (MCI), which often progresses to Alzheimer’s dementia within a few years.
Neurologists have been eager to find new ways to identify people who are at high risk of Alzheimer’s dementia but do not yet show any symptoms. There is a widespread consensus that Alzheimer’s medications now under development may not work after dementia has set in.
“There’s the exciting possibility here that a decline in the sense of smell can be used to identify people at risk years before they develop dementia,” said principal investigator David R. Roalf, PhD, an assistant professor in the department of Psychiatry at Penn.
Roalf and his colleagues used a simple, commercially available test known as the Sniffin’ Sticks Odor Identification Test, in which subjects must try to identify 16 different odors. They administered the sniff test, and a standard cognitive test (the Montreal Cognitive Assessment), to 728 elderly people.
The subjects had already been evaluated by doctors at Penn with an array of neurological methods, and according to expert consensus had been placed in one of three categories: “healthy older adult,” “mild cognitive impairment,” or “Alzheimer’s dementia.” Roalf and his team used the results from the cognitive test alone, or combined with the sniff test, to see how well they identified subjects in each category.
As researchers report, the sniff test added significantly to diagnostic accuracy when combined with the cognitive test.
For example, the cognitive test alone correctly classified only 75 percent of people with MCI, but that figure rose to 87 percent when the sniff test results were added. Combining the two tests also enabled more accurate identification of healthy older adults and those with Alzheimer’s dementia. The combination even boosted accuracy in assigning people to milder or more advanced categories of MCI.
“These results suggest that a simple odor identification test can be a useful supplementary tool for clinically categorizing MCI and Alzheimer’s, and even for identifying people who are at the highest risk of worsening,” Roalf said.
Prompted by prior studies that have linked a weakening sense of smell to Alzheimer’s, doctors in a few larger dementia clinics already have begun to use smell tests in their assessments of elderly patients. Part of the reason the practice has not yet become common is that the tests that seem most useful take too long to administer. Roalf and colleagues are now trying to develop a briefer test that works as well as the longer ones.
“We’re hoping to shorten the Sniffin’ Sticks test, which normally takes 5 to 8 minutes, down to 3 minutes or so, and validate that shorter test’s usefulness in diagnosing MCI and dementia–we think that will encourage more neurology clinics to do this type of screening,” Roalf said.
Roalf and his laboratory also plan to investigate whether protein markers of Alzheimer’s, which are present in the olfactory region of the brain before dementia occurs, can be detected in nasal fluid to provide an even earlier warning of the disease process.
Studies suggest that a high proportion of older adults who have cognitive impairment are not identified as such, in part due to lack of adequate screening.
The study’s first author was Penn’s Megan Quarmley; the other co-authors were Paul J. Moberg, Dawn Mechanic-Hamilton, Sushila Kabadi, and David A. Wolk, all of Penn, and Steven E. Arnold of Harvard University and Massachusetts General Hospital. Data for this study was collected through the Penn Memory Center.
Funding: Funding was provided by the National Institute of Mental Health (K01 497 MH102609), National Institute on Aging (P30 AG10124), and the Penn Center of Excellence for Research on Neurodegenerative Diseases.
Source: Johanna Harvey – University of Pennsylvania School of Medicine
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Abstract for “Odor Identification Screening Improves Diagnostic Classification in Incipient Alzheimer’s Disease” by Quarmley, Megan; Moberg, Paul J.; Mechanic-Hamilton, Dawn; Kabadi, Sushila; Arnold, Steven E.; Wolk, David A.; and Roalf, David R. in Journal of Alzheimer’s Disease. Published online December 20 2016 doi:10.3233/JAD-160842
[cbtabs][cbtab title=”MLA”]University of Pennsylvania School of Medicine “Study Confirms Sniff Test May Be Useful in Diagnosing Early Alzheimer’s.” NeuroscienceNews. NeuroscienceNews, 20 December 2016.
<https://neurosciencenews.com/alzheimers-sniff-test-5782/>.[/cbtab][cbtab title=”APA”]University of Pennsylvania School of Medicine (2016, December 20). Study Confirms Sniff Test May Be Useful in Diagnosing Early Alzheimer’s. NeuroscienceNew. Retrieved December 20, 2016 from https://neurosciencenews.com/alzheimers-sniff-test-5782/[/cbtab][cbtab title=”Chicago”]University of Pennsylvania School of Medicine “Study Confirms Sniff Test May Be Useful in Diagnosing Early Alzheimer’s.” https://neurosciencenews.com/alzheimers-sniff-test-5782/ (accessed December 20, 2016).[/cbtab][/cbtabs]
Abstract
Odor Identification Screening Improves Diagnostic Classification in Incipient Alzheimer’s Disease
Background: Measurements of olfaction may serve as useful biomarkers of incipient dementia. Here we examine the improvement in diagnostic accuracy of Alzheimer’s disease (AD) and mild cognitive impairment (MCI) when assessing both cognitive functioning and odor identification.
Objective: To determine the utility of odor identification as a supplementary screening test in incipient AD. Methods: Sniffin’ Sticks Odor Identification Test (SS-OIT) and the Montreal Cognitive Assessment (MoCA) were administered in 262 AD, 174 MCI [150 amnestic (aMCI), and 24 non-amnestic (naMCI)], and 292 healthy older adults (HOA).
Results: Odor identification scores were higher in HOA relative to MCI or AD groups, and MCI outperformed AD. Odor identification scores were higher in aMCI single domain than aMCI multiple domain. Complementing MoCA scores with the SS-OIT significantly improved diagnostic accuracy of individuals with AD and MCI, including within MCI subgroups.
Discussion: Odor identification is a useful supplementary screening tool that provides additional information relevant for clinical categorization of AD and MCI, including those who are at highest risk to convert to AD.
“Odor Identification Screening Improves Diagnostic Classification in Incipient Alzheimer’s Disease” by Quarmley, Megan; Moberg, Paul J.; Mechanic-Hamilton, Dawn; Kabadi, Sushila; Arnold, Steven E.; Wolk, David A.; and Roalf, David R. in Journal of Alzheimer’s Disease. Published online December 20 2016 doi:10.3233/JAD-160842
