In patients with ALS, astrocytes within the brain become pro-inflammatory and tend to lose their protective function, resulting in changes in the ability to uptake glutamate.
Older adults with an academic background showed lower increases of signs of brain degeneration than those who were less educated, a new study reports.
Researchers have identified high levels of three gut-produced toxic metabolites in plasma and cerebrospinal fluid samples of patients with multiple sclerosis.
Increased ceramide levels in the brain may be a unique feature of all types of Lewy body dementias, including LBD associated with Parkinson's disease.
A new study reveals how adipocytes, or fat cells, play a role in cognitive decline and increased neurodegeneration risks. Using genetically modified mouse models, researchers found oxidative stress through exposure to a Western diet increased the production of inflammatory cytokines confined to adipocytes and altered protein markers of memory and cognition in the hippocampus.
Some viral infections could increase intercellular spreading of protein aggregates associated with neurodegenerative disorders, increasing the risk for developing Alzheimer's, Parkinson's, and other neurodegenerative diseases.
Study reveals the molecular mechanisms implicated in the regulation of toxic proteins in neurodegenerative diseases like Alzheimer's and Parkinson's disease.
Researchers report Alzheimer's disease and other neurodegenerative disorders can be confirmed in living patients by specific biomarkers in cerebrospinal fluid.
People diagnosed with Alzheimer's or mild cognitive impairment had weaker gamma wave activation in their brains than their peers without the neurodegenerative disorders.
Lower serum levels of the sugar metabolite GlcNAc was associated with progressive disability and neurodegeneration in patients with multiple sclerosis.
Cells that drive myelin repair become less efficient due to aging. Myelin loss results in cognitive decline and is central to a number of neurodegenerative diseases.