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neurodegeneration

Rejuvenation of Microglia by Youth Protein TIMP2 in the Aging Brain

·August 14, 2026·4 min read

Youth Protein TIMP2 Restores Immune Function in the Aging Brain

Researchers discovered that the youth-associated protein TIMP2 restores healthy immune function in the aging brain by rejuvenating microglia.

Featured Neurology Neuroscience

·July 9, 2026·13 min read

NFL Players Face Fourfold Increase in Neurodegenerative Mortality

A retrospective cohort study of 19,824 NFL players confirms that professional football veterans face a fourfold increase in neurodegenerative mortality, including a 3.8-fold surge in all-cause dementia and Parkinson's disease.

Featured Genetics Neurology Neuroscience

·June 25, 2026·9 min read

Immune Receptor TREM-1 Amplifies Neuroinflammation

A new study outlines the biological role of TREM-1 as a master upstream amplifier of innate immunity, highlighting its synergy with Toll-like receptors and its emergence as a high-value therapeutic target for stopping acute sepsis, inflammatory arthritis, and microglial-driven neurodegeneration.

Featured Neurology Neuroscience

·June 2, 2026·12 min read

Charting 54,583 Connectomes to Detect Brain Disease

The global framework validates the "last in, first out" theory of brain aging while revealing that individuals sharing the same clinical diagnosis exhibit completely unique microstructural deviations.

Featured Genetics Neurology Neuroscience

·May 13, 2026·8 min read

APOE2 Protects Neurons from DNA Damage and Aging

Researchers discovered that the APOE2 gene variant shields the brain by helping neurons repair DNA damage and resist cellular senescence. By shifting focus from lipid transport to genomic integrity, this study identifies a new biological mechanism for longevity and suggests that mimicking APOE2's effects could lead to breakthrough treatments for Alzheimer’s disease.

Featured Neurology Neuroscience

·May 12, 2026·7 min read

Slowing Parkinson’s by Blocking a Key Protein

A new study found that GPNMB, released by the brain's immune cells, accelerates the spread of toxic alpha-synuclein. By using monoclonal antibodies to block GPNMB, the team successfully interrupted the cycle of neurodegeneration in preclinical models. This discovery provides a new therapeutic target that could finally slow the progression of Parkinson’s at its earliest stages.

Featured Neurology Neuroscience

·May 8, 2026·8 min read

Brain Pathway Identification Could Slow Parkinson’s

Researchers identified a sex-specific pathway that preserves dopamine-producing neurons in females. By reinforcing nicotine-responsive receptors without using nicotine, the team successfully reduced signs of degeneration, marking a critical step toward disease-modifying therapies.

Featured Neurology Neuroscience

·April 22, 2026·7 min read

White Matter Damage Triggers Repair and Disease Cycles

Researchers found that localized white matter damage causes remote grey matter loss, but regenerating myelin can reverse the damage.

Featured Neurology Neuroscience

·April 20, 2026·9 min read

Gut Bacteria May Predict Parkinson’s Before Symptoms Appear

A major study identifies 176 gut microbe species that signal Parkinson’s risk years before symptoms, suggesting that gut health is a key early warning system for the disease.

Featured Genetics Neuroscience

·April 18, 2026·8 min read

Glutathione Prevents Cellular Clogs

Researchers have identified SLC33A1 as the key transporter that maintains the ER’s glutathione balance, ensuring proteins fold correctly and preventing the "cellular debris" linked to neurodegeneration.

Featured Neuroscience

·April 7, 2026·8 min read

Cnpy1 Protects Stressed Neurons

Researchers have identified the Cnpy1 protein as a vital survival factor for pheromone-detecting neurons. The study shows how these specialized cells co-opt "ER-stress" pathways to function, with Cnpy1 acting as a cellular stabilizer.

Featured Neurology Neuroscience

·March 27, 2026·8 min read

AI Links Brain Rhythms to Physical “Wiring” Across Lifespan

A study of 1,965 people aged 5–100 reveals that brain wave speed is dictated by the brain's physical wiring. The new Xi–αNET model shows that slowing alpha waves are a direct marker of declining white matter in aging.

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neurodegeneration

Youth Protein TIMP2 Restores Immune Function in the Aging Brain

NFL Players Face Fourfold Increase in Neurodegenerative Mortality

Immune Receptor TREM-1 Amplifies Neuroinflammation

Charting 54,583 Connectomes to Detect Brain Disease

APOE2 Protects Neurons from DNA Damage and Aging

Slowing Parkinson’s by Blocking a Key Protein

Brain Pathway Identification Could Slow Parkinson’s

White Matter Damage Triggers Repair and Disease Cycles

Gut Bacteria May Predict Parkinson’s Before Symptoms Appear

Glutathione Prevents Cellular Clogs

Cnpy1 Protects Stressed Neurons

AI Links Brain Rhythms to Physical “Wiring” Across Lifespan

How Severe Illness During Pregnancy Alters Fetal Brain Development

Aging Brains Maintain Robust Language Networks Despite Cognitive Decline

Youth Protein TIMP2 Restores Immune Function in the Aging Brain

Shame, Stigma, and Culture Prevent Male Domestic Violence Survivors From Seeking Help

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