An older person's posture may give clues to hidden cognitive decline, a new study reports.
The aged non-human primate hippocampus showed signs of increased inflammation, genomic and epigenomic instability, and a loss of proteostasis.
Researchers have identified the cellular and molecular mechanisms that regulate selective autophagy.
NU-9, an experimental drug, appears to be more effective at treating ALS than existing medications.
Study reveals a new mechanism that appears to reverse the build-up of protein aggregates by refolding them, rather than removing them.
Amyloid fibrils in those with frontotemporal lobar degeneration (FTLD) contain a little-known protein called TMEM106B. Researchers speculate TMEM106B could be found to be the cause of FTLD.
An abundance of newly acquired mutations in the mutations that occur at an accelerated speed is a telling pattern of Alzheimer's disease, researchers report.
Study confirms neurofilament light is a useful blood-based biomarker for frontotemporal dementia, PSP, and primary progressive aphasia.
Wolframin-expressing excitatory neurons (WFS1) are more vulnerable in the entorhinal cortex.WFS1 may reduce tau-pathology and neurodegeneration via the regulation of stress response to the abnormal buildup of tau aggregates and the downstream protein degradation pathway.
mRNA decay may facilitate tau-induced damage to the brain and associated apoptosis that contributes to a range of neurodegenerative disorders. Researchers found the mechanism can be altered pharmacologically, providing a new target for the development of therapeutics to prevent or slow the progression of some neurodegenerative disorders.
Patients who suffer from frontotemporal dementia with extrapyramidal symptoms have brainstem atrophy and reduced metabolic activity in specific brain regions compared to those with FTD without extrapyramidal symptoms.
An innovative new system that includes electronic implants directly onto the spinal cord reactivates neurons that control blood pressure, allowing a patient with multiple system atrophy-parkinsonian type (MSA-P) to retain consciousness when she is in an upright position.
