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neurodegeneration

Featured Genetics Neurology Neuroscience

·February 16, 2026·9 min read

Two Genetic “Hits” Required to Trigger Parkinson’s Neurodegeneration

Researchers find that a mutation in GBA1 must be paired with an ATP13A2 mutation to drive the neurodegeneration seen in Parkinson’s disease.

This shows metabolic pathways in the brain.

Featured Neurology Neuroscience

·February 13, 2026·9 min read

Parkinson’s Triggers a Hidden Metabolic Shift

Think Parkinson's weight loss is just about nutrition? New research shows it’s actually a sign of an internal energy engine failure. By switching to a fat-burning "emergency engine," the body tries to compensate for a brain in crisis, making thinness a vital biological warning sign.

This shows glowing neurons, as though they are the target scientists discovered.

Featured Genetics Neurology Neuroscience

·February 12, 2026·8 min read

New Drug Target Could Freeze Alzheimer’s in Its Tracks

Is the IDOL enzyme the key to stopping Alzheimer's? New research shows that blocking this single target can dissolve brain plaques and boost cognitive resilience. By lowering the brain's "strongest risk factor" protein, scientists have found a new way to keep neurons communicating even under attack.

This shows a microscopy image of myelin swelling in a brain sample.

Featured Neurology Neuroscience

·February 12, 2026·9 min read

Hidden Dynamics of Early Multiple Sclerosis Myelin Damage

New research suggests that the earliest signs of MS damage are surprisingly dynamic. By tracking myelin swellings in 3D, scientists have discovered that these precursors to lesions can actually shrink and disappear, revealing a hidden opportunity to stop the disease before it starts.

This shows healthy microglia and neurons.

Featured Neurology Neuroscience

·August 11, 2025·8 min read

Microglia Transplant Restores Function in Degenerative Brain Disease

Scientists have developed a targeted brain cell transplant that could transform treatment for Tay-Sachs and Sandhoff diseases. By depleting diseased microglia and replacing them with healthy donor precursor cells, researchers restored crucial enzyme function in the brain and dramatically extended lifespan in mice.

Featured Genetics Neurology Neuroscience

·June 25, 2025·5 min read

Newborns and Alzheimer’s Patients Share a Brain Protein Spike

A new study has revealed that newborn babies and Alzheimer’s patients both have elevated levels of the same protein, p-tau217, in their blood. While this protein is a key marker of brain degeneration in Alzheimer’s, in newborns it appears to support healthy brain growth and development.

Featured Neurology Neuroscience

·April 30, 2025·5 min read

Skin Test Detects Neurodegenerative Disease PSP with High Accuracy

Researchers have developed a skin-based test that can detect misfolded tau proteins specific to progressive supranuclear palsy (PSP), offering a faster, more accurate diagnosis than current methods. This breakthrough could improve patient assignment to clinical trials and eventually guide targeted, precision treatments.

Featured Neuroscience

·January 21, 2025·5 min read

Microglia Act Differently in Male and Female Brains

Microglia, the brain’s immune cells, play vital roles in clearing toxins and maintaining neuronal health but can also contribute to neurodegenerative diseases if overactive. New research reveals sex-based differences in how adult male and female microglia respond to the enzyme inhibitor PLX3397, a common tool in microglial research. While male microglia showed the expected depletion, female microglia employed alternative signaling pathways, leading to increased survival.

Featured Neuroscience

·October 22, 2024·3 min read

“Zombie” Aging Cells May Speed Up Brain Decline

Recent research shows that senescent, or "zombie," skin cells may accelerate aging throughout the body. When transplanted into a preclinical model, these cells caused senescence to spread to other organs, impairing muscle function and brain health.

Featured Genetics Neurology Neuroscience

·October 1, 2024·3 min read

New Genetic Syndrome Links Brain Development and Degeneration

Researchers have discovered a new genetic syndrome caused by a mutation in the SPAG9 gene that affects both neurodevelopment and neurodegeneration. The study identified three siblings with intellectual disability, speech delays, and progressive cognitive decline, linking the mutation to disruptions in brain structure and function. Neuroimaging revealed abnormalities such as microcephaly, hippocampal malrotation, and cerebral atrophy.

Featured Neurology Neuroscience

·August 16, 2024·5 min read

Restoring Brain’s Waste-Clearing System Reverses Aging Effects

New research in mice reveals that aging slows the brain's ability to clear out harmful waste, contributing to neurological disorders like Alzheimer's and Parkinson's. Scientists have found that restoring function in the brain's waste-clearing system, known as the glymphatic system, can reverse these age-related effects. Using a clinically approved drug, researchers increased the efficiency of waste removal, offering a potential treatment strategy for age-related brain diseases.

Featured Neurology Neuroscience

·April 8, 2024·4 min read

Revolutionizing Neuron Observation for Disease Insight

A new neuron labeling technology, NeuM, has been developed, offering unprecedented insights into the mechanisms of neurodegenerative disorders like Alzheimer's and Parkinson's disease. NeuM enables selective, high-resolution visualization of neuronal membranes, allowing for the detailed monitoring of neuronal changes in real-time.

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neurodegeneration

Two Genetic “Hits” Required to Trigger Parkinson’s Neurodegeneration

Parkinson’s Triggers a Hidden Metabolic Shift

New Drug Target Could Freeze Alzheimer’s in Its Tracks

Hidden Dynamics of Early Multiple Sclerosis Myelin Damage

Microglia Transplant Restores Function in Degenerative Brain Disease

Newborns and Alzheimer’s Patients Share a Brain Protein Spike

Skin Test Detects Neurodegenerative Disease PSP with High Accuracy

Microglia Act Differently in Male and Female Brains

“Zombie” Aging Cells May Speed Up Brain Decline

New Genetic Syndrome Links Brain Development and Degeneration

Restoring Brain’s Waste-Clearing System Reverses Aging Effects

Revolutionizing Neuron Observation for Disease Insight

How Severe Illness During Pregnancy Alters Fetal Brain Development

Aging Brains Maintain Robust Language Networks Despite Cognitive Decline

Youth Protein TIMP2 Restores Immune Function in the Aging Brain

Shame, Stigma, and Culture Prevent Male Domestic Violence Survivors From Seeking Help

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