When It Comes to ADHD and ASD, the Eyes Could Reveal All

Summary: Measuring the electrical activity of the retina in response to light stimulus could be a biomarker for ADHD and autism, researchers report.

Source: University of South Australia

It’s often said that ‘the eyes tell it all’, but no matter what their outward expression, the eyes may also be able to signal neurodevelopmental disorders such as ASD and ADHD according to new research from Flinders University and the University of South Australia.

In the first study of its kind, researchers found that recordings from the retina could identify distinct signals for both Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) providing a potential biomarker for each condition.

Using the ‘electroretinogram’ (ERG) – a diagnostic test that measures the electrical activity of the retina in response to a light stimulus – researchers found that children with ADHD showed higher overall ERG energy, whereas children with ASD showed less ERG energy.

Research optometrist at Flinders University, Dr Paul Constable, says the preliminary findings indicate promising results for improved diagnoses and treatments in the future.

“ASD and ADHD are the most common neurodevelopmental disorders diagnosed in childhood. But as they often share similar traits, making diagnoses for both conditions can be lengthy and complicated,” Dr Constable says.

“Our research aims to improve this. By exploring how signals in the retina react to light stimuli, we hope to develop more accurate and earlier diagnoses for different neurodevelopmental conditions.

“Retinal signals have specific nerves that generate them, so if we can identify these differences and localize them to specific pathways that use different chemical signals that are also used in the brain, then we can show distinct differences for children with ADHD and ASD and potentially other neurodevelopmental conditions.”

“This study delivers preliminary evidence for neurophysiological changes that not only differentiate both ADHD and ASD from typically developing children, but also evidence that they can be distinguished from each other based on ERG characteristics.”

According to the World Health Organization, one in 100 children has ASD, with 5-8 percent of children diagnosed with ADHD.

This shows an eye
Research optometrist at Flinders University, Dr Paul Constable, says the preliminary findings indicate promising results for improved diagnoses and treatments in the future. Image is in the public domain

Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental condition characterised by being overly active, struggling to pay attention, and difficulty controlling impulsive behaviours. Autism spectrum disorder (ASD) is also a neurodevelopmental condition where children behave, communicate, interact, and learn in ways that are different from most other people.

Co-researcher and expert in human and artificial cognition at the University of South Australia, Dr Fernando Marmolejo-Ramos, says the research has potential to extend across other neurological conditions.

“Ultimately, we’re looking at how the eyes can help us understand the brain,” Dr Marmolejo-Ramos says.

“While further research is needed to establish abnormalities in retinal signals that are specific to these and other neurodevelopmental disorders, what we’ve observed so far shows that we are on the precipice of something amazing.

“It is truly a case of watching this space; as it happens, the eyes could reveal all.”

This research was conducted in partnership with McGill University, University College London and the Great Ormond Street Hospital for Children.

About this ADHD and ASD research news

Author: Annabel Mansfield
Source: University of South Australia
Contact: Annabel Mansfield – University of South Australia
Image: The image is in the public domain

Original Research: Open access.
Discrete Wavelet Transform Analysis of the Electroretinogram in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder” by Fernando Marmolejo-Ramos et al. Frontiers in Neuroscience


Discrete Wavelet Transform Analysis of the Electroretinogram in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder

Background: To evaluate the electroretinogram waveform in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) using a discrete wavelet transform (DWT) approach.

Methods: A total of 55 ASD, 15 ADHD and 156 control individuals took part in this study. Full field light-adapted electroretinograms (ERGs) were recorded using a Troland protocol, accounting for pupil size, with five flash strengths ranging from –0.12 to 1.20 log photopic cd.s.m–2. A DWT analysis was performed using the Haar wavelet on the waveforms to examine the energy within the time windows of the a- and b-waves and the oscillatory potentials (OPs) which yielded six DWT coefficients related to these parameters. The central frequency bands were from 20–160 Hz relating to the a-wave, b-wave and OPs represented by the coefficients: a20, a40, b20, b40, op80, and op160, respectively. In addition, the b-wave amplitude and percentage energy contribution of the OPs (%OPs) in the total ERG broadband energy was evaluated.

Results: There were significant group differences (p < 0.001) in the coefficients corresponding to energies in the b-wave (b20, b40) and OPs (op80 and op160) as well as the b-wave amplitude. Notable differences between the ADHD and control groups were found in the b20 and b40 coefficients. In contrast, the greatest differences between the ASD and control group were found in the op80 and op160 coefficients. The b-wave amplitude showed both ASD and ADHD significant group differences from the control participants, for flash strengths greater than 0.4 log photopic cd.s.m–2 (p < 0.001).

Conclusion: This methodological approach may provide insights about neuronal activity in studies investigating group differences where retinal signaling may be altered through neurodevelopment or neurodegenerative conditions. However, further work will be required to determine if retinal signal analysis can offer a classification model for neurodevelopmental conditions in which there is a co-occurrence such as ASD and ADHD.

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  1. The adults of the world need to realise that children are a lot more like adults than they realise. They don’t want to be listening to the ramblings of adults who think they should be inflicting information on them. Even I switch off when people talk too much. We need to be exploring the damage we are doing with our belief system. Us adults are condemning these kids to a life of non acceptance. To tell a child there is something wrong with them when there is something very wrong with the adults who do this is what causes behaviour like this. Adults will come into realisation at some point that we are the cause of all mental health issues and behaviour problems within ourselves and our children.
    People only need to realise that state of mind tells us to keep accepting being abused, children are feeling the affects of their parents being abused by the governments worldwide. Want to solve both adults issues and children’s?
    Help every adult to get out of state slavery so that they can start thinking for themselves, properly.
    Thank you for your time.

  2. Question? If science is showing ADHD has to do with the retinal? How does ADHD medication work? Also being premature. With a lazy eye affect ADHD? Mostly the main question is ADHD medicine. It works.

  3. Hello both of my children have an ass diagnosis. My oldest is now 21 and he developed normally including language until he was almost two. Then he lost all language for many years. He still has very little language. You can clearly see in pictures of both of them the early pictures where they have brightness in their eyes. Then the absolute after their eyes have lost all of that bright. My youngest son is almost 20. He never regressed any of his skills. He developed everything early potty trained himself taught himself to read before kindergarten and is teaching himself all the languages on Google translate. Yet struggles to tell you how his day was or why he is upset. Also he struggles with self injury and aggression. The eyes in pics show something clearly is changed in all the baby pics of both.

  4. Will this research also be done with adults? The DSM is all about diagnosing children, but is very biased against people who did not present as ADHD in childhood. So having another tool to prove that we indeed have it would be most helpful.

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