Summary: Study challenges the widely accepted belief that all light information is relayed through the suprachiasmatic nucleus, which synchronizes the circadian rhythm. Source: Northwestern University Either to check the time or waste time, people often look at their smartphones after waking in the middle of the night. While this acute burst of light does make it more difficult to fall back to sleep, a new Northwestern University study reports that it won’t interfere with the body’s overall circadian rhythms. For the first time, researchers directly tested how short pulses of light are processed by the brain to affect sleep. They discovered that separate areas of the brain are responsible for short pulses versus long-term exposure to light. This finding challenges the widely accepted, long-held belief that all light information is relayed through the brain’s suprachiasmatic nucleus (SCN), which synchronizes the body’s sleep/wake cycles. “Prior to the widespread use of electricity, our exposure to light and darkness occurred in a very predictable pattern,” said Northwestern’s Tiffany Schmidt, who led the study. “But light has become very cheap. We all have smartphones, and their screens are very bright. We’re all getting exposed to light at the wrong times of day. It’s becoming more important to understand how these different types of light information are relayed to the brain.” The paper will publish July 23 in the journal eLife. Schmidt is an assistant professor of neurobiology in Northwestern’s Weinberg College of Arts and Sciences. The study was carried out in collaboration with the laboratories of Fred Turek, the Charles and Emma Morrison Professor of Neurobiology in Weinberg, and Samer Hattar, section leader at the National Institute of Mental Health. After light enters the eye, specialized neurons called intrinsically photosensitive retinal ganglion cells (ipRGCs) carry the light information to the brain. Before Northwestern’s study, researchers widely believed that all light information went through the SCN, a densely packed area in the hypothalamus known as the body’s “circadian pacemaker.” “Light information comes into the SCN, and that’s what synchronizes all of the body’s clocks to the light/dark cycle,” Schmidt said. “This one master pacemaker makes sure everything is in sync.” This helps explain why one night of restless sleep and smartphone gazing might make a person feel tired the following day but does not have a long-term effect on the body. The image is in the public domain. To conduct the study, Schmidt and her team used a genetically modified mouse model that only had ipRGCs projecting to the SCN — but no other brain regions. Because mice are nocturnal, they fall asleep when exposed to light. The mice in the experiment, however, stayed awake when exposed to short pulses of light at night. The mice’s body temperature, which also correlates to sleep, also did not respond to the short-term light. The mice maintained a normal sleep/wake cycle and normal rhythms in their body temperature, suggesting that their overall circadian rhythms remained intact. This helps explain why one night of restless sleep and smartphone gazing might make a person feel tired the following day but does not have a long-term effect on the body. “If these two effects — acute and long-term light exposure — were driven through the same pathway, then every minor light exposure would run the risk of completely shifting our body’s circadian rhythms,” Schmidt said. Now that researchers know that the light-response system follows multiple pathways, Schmidt said more work is needed to map these pathways. For one, it is still unknown what area of the brain is responsible for processing acute light. After more is known, then researchers might understand how to optimize light exposure to increase alertness in those who need it, such as nurses, shift workers, and emergency personnel, while mitigating the harmful effects of a wholesale shift in circadian rhythms.See alsoFeaturedGeneticsNeuroscienceOpen Neuroscience Articles·February 4, 2020Dopamine signals may guide migration of immune cells to infection sites “Light at the wrong time of day is now recognized as a carcinogen,” Schmidt said. “We want people to feel alert while they are exposed to light without getting the health risks that are associated with shifted circadian rhythms, such as diabetes, depression and even cancer.” Funding: The study, “Distinct ipRGC subpopulations mediate light’s acute and circadian effects on body temperature and sleep,” was supported by the National Institutes of Health (award numbers 1DP2EY027983, GM076430 and EY024452), a Klingenstein-Simons Fellowship in the Neurosciences and a Sloan Research Fellowship in Neuroscience. [divider]About this neuroscience research article[/divider] Source: Northwestern University Media Contacts: Amanda Morris – Northwestern University Image Source: The image is in the public domain. Original Research: The study will be published in eLife on July 23, 2019. [divider]Feel free to share this Neuroscience News.[/divider] Join our Newsletter I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information ) Sign up to receive the latest neuroscience headlines and summaries sent to your email daily from NeuroscienceNews.comWe hate spam and only use your email to contact you about newsletters. We do not sell email addresses. You can cancel your subscription any time.