A mutation in a gene associated with circadian rhythm extends the clock period, causing people to stay up late at night and sleep late in the mornings. Read More
Jet lag alters the microenvironment around cancerous tumor cells, making it more favorable for tumors to grow, and hinders the body's natural immune response. Read More
Study reveals how sleep deprivation can greatly affect soldiers on the battlefield. Read More
During wakeful periods, the glymphatic system diverts cerebrospinal fluid to lymph nodes in the neck. The CSF may act as a "fluid clock" that helps initiate the body's infection-fighting capabilities during the day. Astrocytes in the suprachiasmatic nucleus may serve to control CSF through the central nervous system. Communication between astrocytes in different brain regions may optimize the glymphatic system's function as we sleep. Read More
Both food timing and the integrity of the internal clock in the liver altered rhythms of metabolism in mice. Almost half of the rhythmic genes are regulated by both the internal clock and when food is ingested. Read More
Altering the structure of perineuronal nets could be a mechanism that underlies sleep-induced memory changes. Read More
Circadian rhythm disruptions in older men have been linked to an increased risk of developing Parkinson's disease. The findings suggest circadian disruptions may reflect the neurodegenerative processes already affecting the brain's internal clock prior to the diagnosis of Parkinson's. Circadian disruptions, researchers say, could be considered an early warning sign of Parkinson's. Read More
Researchers uncover an intimate connection between methylation and the body's circadian rhythms. Read More
Recovered stroke patients who suffer from sleep-wake disruptions are more likely to experience another stroke, researchers report. Read More
A new study puts into question conventional belief that the eyes communicate with the brain exclusively via one signaling pathway. Researchers have identified a subset of retinal neurons that sends inhibitory signals to the brain. This subset of neurons is also involved in the synchronization of circadian rhythms to light/dark cycles and pupil constriction to bright light intensity. Read More
Two small molecules, KL101 and TH301, are the first compounds that selectively target circadian clock components CRY1 and CRY2. Read More
Older children have stronger neural responses to rewards over punishments later in the afternoon. In younger children, this pattern is reversed. Read More
