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Brain ‘Stethoscope’ Listens For Silent Seizures

Summary: Researchers have developed what they have dubbed a ‘brain stethoscope’, a device capable of turning EEG brain wave data into sound. The device is able to detect epileptic seizures that do not result in convulsions.

Source: Stanford.

When a doctor or nurse suspects something is wrong with a patient’s heart, there’s a simple way to check: put a stethoscope over the heart and listen to the sounds it makes. Doctors and nurses can use the same diagnostic tool to figure out what’s going on with the heart, lungs, stomach and more, but not the brain – although that could change with a new device.

Over the past several years, Stanford neurologists have been working with a specialist in computer music to develop a brain stethoscope – not a stethoscope per se, but rather an algorithm that translates the brain’s electrical activity into sounds.

Now, the same team has shown that medical students and nurses – non-specialists, in other words – can listen to the brain stethoscope and reliably detect so-called silent seizures – a neurological condition in which patients have epileptic seizures without any of the associated physical convulsions. The group published the work March 21 in the journal Epilepsia.

“This technology will enable nurses, medical students and physicians themselves to actually assess their patient right there and they will be able to determine if the patient is having silent seizures,” said Josef Parvizi, a professor of neurology and neurological sciences.

Seizures of a different sort

The desire for a brain stethoscope stems from a basic problem with treating epileptic seizures – namely, a great many of them may go undetected and untreated.

Technically, a seizure is a neurological problem, in which ordinarily calm electrical brain waves go haywire. That erratic activity can cause convulsions – but not always.

“You might think that all seizures must cause some sort of convulsions, namely a patient who’s having a seizure must fall down and shake on the ground. But that’s actually not the case, especially in critically ill patients in the intensive care units,” said Parvizi, who is also a member of Stanford Bio-X, the Stanford Neurosciences Institute and the Child Health Research Institute. “Close to 90 percent of those patients will have silent seizures,” he said, and though not visible they can still damage the brain if they are prolonged.

On top of that, diagnosing silent seizures can be a drawn-out process, even during regular hours at a major hospital like Stanford’s. First, a trained technician comes in, sets up sensors on a patient’s skull to record the brain’s electrical activity, then makes a recording and sends it to a neurology specialist like Parvizi for analysis. By the time the diagnosis comes in, hours may have passed. After hours or in smaller hospitals, the process can take even longer – for one thing, a technician may have to come from hours away just to set up the equipment.

Music of the mind

The solution came, Parvizi said, after watching Kronos Quartet perform a piece of music based on data recorded by a scientific instrument aboard the Voyager space probe. Parvizi realized something similar could be done with brain waves, so he sent some data files to Chris Chafe, the Duca Family Professor and a professor of music.

brain stethoscope

Stanford researchers have developed a “brain stethoscope” that can help detect non-convulsive epileptic seizures. NeuroscienceNews.com image is adapted from the Stanford video.

“I had never even entertained the idea that we would attach some of my music synthesis to somebody’s head,” said Chafe, who is also a member of Bio-X and the Neurosciences Institute. But it wasn’t particularly odd either – Chafe has also made music out of climate change data and the carbon dioxide generated by ripening tomatoes. In this case, he used brain-wave data to modulate the singing sounds of a computer-synthesized voice – a natural choice, Chafe said, given the context.

“Once he sent me the files and I listened to them, I was literally in shock, because it was so intuitive,” Parvizi said. “You could hear the transition from non-seizure to seizure so easily, that I just basically picked up the phone and told Chris that we have something right here.”

So easy a medical student can do it

But Parvizi is a trained neurologist, and to really test the potential of a brain stethoscope he needed to see if non-specialists could hear the difference between normal brain activity and a seizure. With the help of a Bio-X seed grant, Kapil Gururangan, a medical student, and Babak Razavi, a clinical assistant professor of neurology, gathered 84 brain wave samples, called electroencephalograms or EEGs, 32 of which included either a seizure or some features typical of one. Then, they turned those samples into music using Chafe’s algorithm and played them for 34 medical students and 30 nurses at Stanford.

Despite having no training in the diagnosis of epilepsy, medical students and nurses were remarkably good at discerning seizures and seizure-like events from normal brain waves. “The ability of an untrained medical student or nurse to read an EEG is pretty dismal — it’s 50 percent,” Gururangan said. But by listening to that EEG transformed into sound, medical students and nurses could accurately detect seizures more than 95 percent of the time.

Medical students and nurses also correctly identified samples with seizure-like features about three-quarters of the time and they correctly identified normal activity at similar rates – not perfect, but not bad either, given their training, Gururangan said.

“The question now that we have to figure out is: How are actual physicians going to use this tool and how do physicians use this information in their decision-making?” Gururangan said. In other words, the team has a number of questions it is still looking to answer, but the early results sound good.

About this neuroscience research article

Source: Nathan Collins – Stanford
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is adapted from the Stanford video.
Video Source: Video credited to Stanford.
Original Research: Open access research in Epilepsia.
doi:10.1111/epi.14043

Cite This NeuroscienceNews.com Article
Stanford “Brain ‘Stethoscope’ Listens For Silent Seizures.” NeuroscienceNews. NeuroscienceNews, 22 March 2018.
<http://neurosciencenews.com/seizures-brain-waves-8673/>.
Stanford (2018, March 22). Brain ‘Stethoscope’ Listens For Silent Seizures. NeuroscienceNews. Retrieved March 22, 2018 from http://neurosciencenews.com/seizures-brain-waves-8673/
Stanford “Brain ‘Stethoscope’ Listens For Silent Seizures.” http://neurosciencenews.com/seizures-brain-waves-8673/ (accessed March 22, 2018).

Abstract

Detecting silent seizures by their sound

Objective
The traditional approach to interpreting electroencephalograms (EEGs) requires physicians with formal training to visually assess the waveforms. This approach can be less practical in critical settings where a trained EEG specialist is not readily available to review the EEG and diagnose ongoing subclinical seizures, such as nonconvulsive status epilepticus.

Methods
We have developed a novel method by which EEG data are converted to sound in real time by letting the underlying electrophysiological signal modulate a voice tone that is in the audible range. Here, we explored whether individuals without any prior EEG training could listen to 15‐second sonified EEG and determine whether the EEG represents seizures or nonseizure conditions. We selected 84 EEG samples to represent seizures (n = 7), seizure‐like activity (n = 25), or nonperiodic, nonrhythmic activity (normal or focal/generalized slowing, n = 52). EEGs from single channels in the left and right hemispheres were then converted to sound files. After a 4‐minute training video, medical students (n = 34) and nurses (n = 30) were asked to designate each audio sample as “seizure” or “nonseizure.” We then compared their performance with that of EEG‐trained neurologists (n = 12) and medical students (n = 29) who also diagnosed the same EEGs on visual display.

Results
Nonexperts listening to single‐channel sonified EEGs detected seizures with remarkable sensitivity (students, 98% ± 5%; nurses, 95% ± 14%) compared to experts or nonexperts reviewing the same EEGs on visual display (neurologists, 88% ± 11%; students, 76% ± 19%). If the EEGs contained seizures or seizure‐like activity, nonexperts listening to sonified EEGs rated them as seizures with high specificity (students, 85% ± 9%; nurses, 82% ± 12%) compared to experts or nonexperts viewing the EEGs visually (neurologists, 90% ± 7%; students, 65% ± 20%).

Significance
Our study confirms that individuals without EEG training can detect ongoing seizures or seizure‐like rhythmic periodic patterns by listening to sonified EEG. Although sonification of EEG cannot replace the traditional approaches to EEG interpretation, it provides a meaningful triage tool for fast assessment of patients with suspected subclinical seizures.

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