Stem cell study reveals astrocytes carrying the Alzheimer's associated APOE4 gene release more cholesterol than those carrying the APOE3 gene. Findings shed light on how different versions of the APOE gene in astrocytes influence amyloid-beta production and how the oversupply of cholesterol associated with APOE4 astrocytes may promote amyloid-beta formation in Alzheimer's patients.
Cholesterol produced by astrocytes in the brain is required for the production of amyloid-beta. The findings shed light on how and why amyloid-beta forms, and may explain why genes associated with cholesterol have been implicated as risk factors for Alzheimer's disease.
Amyloid-beta proteins created in the liver are carried in the blood by lipoproteins to the brain. This results in neurodegeneration, brain atrophy, and inflammation, which are common features of Alzheimer's disease.
A new bio-inspired slow-release system for site 1 sodium channel blockers helps release anesthesia, providing prolonged nerve blocking with minimal toxicity.
Drugs that stabilize amyloid fibril "frustration" block further aggregation and could provide a new method to prevent the progression of Alzheimer's.
Study reveals the molecular mechanisms implicated in the regulation of toxic proteins in neurodegenerative diseases like Alzheimer's and Parkinson's disease.
Researchers discovered mutations of the OPTN gene resulted in increased herpesvirus 1 growth in the brains of mice, leading to the death of local neurons. This resulted in accelerated neurodegeneration. OPTN deficiency was also associated with impairments in immune response. While these findings are specific to the HSV-1 virus, researchers believe the findings may apply to up to eight herpesvirus infections.
Analyzing the gene activity of 66,000 cells from human brain tissue, researchers generated a comprehensive map of cell types associated with brain lesions in multiple sclerosis, and their gene expression patterns and interactions.
Researchers identified 33 metabolic compounds in blood samples that differed between those with dementia and cognitively healthy older adults. 7 of the metabolites were elevated in dementia patients, while 26 were at lower levels compared to samples of those without dementia. Elevating levels of those metabolites could have a neuroprotective effect against dementia.
Hyperbaric oxygen therapy improved cerebral blood flow by up to 23%, alleviating vascular dysfunction and amyloid burden in elderly patients. The treatment also improved memory by 16.5%.
A study conducted on Japanese men and women found peanut consumption decreased the risk of cardiovascular disease and ischemic stroke.
People with ADHD had a 34% higher risk of developing dementia than those without the disorder. The risk of being diagnosed with Alzheimer's, the most common type of dementia, was 55% higher for those with ADHD.