People who frequently take sleeping medications are 79% more likely to develop dementia than those who never use sleeping pills to aid their rest.
CRISPR gene editing created the G795A amino acid which was introduced to microglia derived from human stem cells. Researchers were able to transplant the donor microglia immune cells into humanized rodent models while administering an FDA-approved cancer drug called pexidartinib. The inclusion of the amino acid cause the donated microglia to thrive and resist the drug, while the host microglia died. The findings open the door for new methods of using microglia to treat a range of neurodegenerative disorders.
In women, parts of the default mode network responsible for memory retrieval and recollection, and spatial cognition were more likely to be connected to the overall DMN network. The patterns of connectivity correlated with brain structures associated with short-term memory problems resembled alterations seen in preclinical Alzheimer's disease.
Chronic pain in mice activates Tiam1 in pyramidal neurons in the anterior cingulate cortex, increasing the number of dendritic spines and inducing synaptic plasticity. Ketamine's antidepressant effect in chronic pain is mediated by the drug blocking Tiam1-dependent maladaptive synaptic plasticity in ACC neurons.
Adding a splash of milk to your cup of coffee can have anti-inflammatory effects, a new study reports. Researchers say the combination of polyphenols and proteins doubles anti-inflammatory properties in immune cells.
Initial memory problems are linked with a slower rate of decline in Alzheimer's disease. Those with symptoms including language difficulties or judgment changes had a more rapid rate of decline than those with memory problems alone.
People with autism experience pain at a higher intensity than those not on the autism spectrum and are less adaptable to the sensation. This revelation contradicts the prevailing belief that those with ASD tend to be indifferent to pain.
Measles virus that persists in the body can develop mutations in the F protein, which controls how the virus infects cells. The mutated protein can interact with its normal form, making it capable of infecting the brain.
Alterations in the cerebral neural network could function as a biomarker for the early diagnosis of mild cognitive impairment, Alzheimer's disease, and Lewy Body dementia.